Frequently Asked Questions (OLAW)  

1. May the IACUC administratively extend approval of a project that has expired?

2. May the IACUC grant conditional or provisional approval?

3. May the investigator begin animal work before receiving IACUC approval?

4. What criteria should the IACUC consider when reviewing protocols?

5. Should the IACUC consider the three "Rs" of alternatives when reviewing protocols? (Refinements to research, Reduction of animal numbers, and Replacement with non-animal models)

6. What is considered a significant change to a project that would require IACUC review?

7. Is the IACUC required to review the grant application?

8. May the IACUC approve pilot studies?

9. Is the IACUC responsible for judging the scientific merit of proposals?

10. If an animal activity will be performed outside of the US (either by a foreign grantee or by a foreign institution as a subproject for a domestic grantee), is the grantee's IACUC required to review and approve that activity?

11. May standard operating procedures (SOPs) or blanket protocols that cover a number of procedures be utilized in lieu of repeating descriptions of identical procedures in multiple protocols?

12. Is IACUC approval required for the collection of samples in foreign countries from captive wild animals or research colonies?

13. Is IACUC approval required for the use of animals in breeding programs, as blood donors, as sentinels in disease surveillance programs, or for other non-research purposes?

14. What guidelines should IACUCs follow for fishes, amphibians, reptiles, birds, and other nontraditional species used in research?

15. Is it acceptable to have different individuals named as PI on the grant application and the IACUC protocol?

16. Should the IACUC inspect laboratories or other sites where investigators use animals?

17. How does the IACUC distinguish between significant and minor deficiencies?

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