Specialized Center of Interdisciplinary Research (SCOR)


Genomic Convergence for Female Osteoporosis Risk Genes




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Peer Reviewed publications from SCOR funding







1.  Xiong DH, Wang JT, Wang W, Guo YF, Xiao P, Shen H, Jiang H, Chen Y, Deng H, Drees B, Recker RR, Deng HW. Genetic determination of osteoporosis: lessons learned from a large genome-wide linkage study. Hum Biol. 2007 Dec;79(6):593-608. PubMed PMID: 18494371.

2.  He LN, Xiong DH, Liu YJ, Zhang F, Recker RR, Deng HW. Association study of the oestrogen signalling pathway genes in relation to age at natural menopause. J Genet. 2007 Dec;86(3):269-76. PubMed PMID: 18305346.

3.  Visscher PM, Macgregor S, Benyamin B, Zhu G, Gordon S, Medland S, Hill WG, Hottenga JJ, Willemsen G, Boomsma DI, Liu YZ, Deng HW, Montgomery GW, Martin NG. Genome partitioning of genetic variation for height from 11,214 sibling pairs. Am J Hum Genet. 2007 Nov;81(5):1104-10. PubMed PMID: 17924350; PubMed Central PMCID: PMC2265649.

4.  Wang L, Liu YJ, Xiao P, Shen H, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. Chromosome 2q32 may harbor a QTL affecting BMD variation at different skeletal sites. J Bone Miner Res. 2007 Nov;22(11):1672-8. PubMed PMID: 17680728.

5.  Jiang C, Lei SF, Liu MY, Xiao SM, Chen XD, Deng FY, Xu H, Tan LJ, Yang YJ, Wang YB, Sun X, Guo YF, Guo JJ, Zhu XZ, Deng HW. Evaluating the correlation and prediction of trunk fat mass with five anthropometric indices in Chinese females aged 20-40 years. Nutr Metab Cardiovasc Dis. 2007 Nov;17(9):676-83. PubMed PMID: 17008072.

6.  Zhang JG, Deng HW. Gene selection for classification of microarray data based on the Bayes error. BMC Bioinformatics. 2007 Oct 3;8(1):370. PubMed PMID: 17915022; PubMed Central PMCID: PMC2089123.

7.  Saunders CL, Chiodini BD, Sham P, Lewis CM, Abkevich V, Adeyemo AA, de Andrade M, Arya R, Berenson GS, Blangero J, Boehnke M, Borecki IB, Chagnon YC, Chen W, Comuzzie AG, Deng HW, Duggirala R, Feitosa MF, Froguel P, Hanson RL, Hebebrand J, Huezo-Dias P, Kissebah AH, Li W, Luke A, Martin LJ, Nash M, Ohman M, Palmer LJ, Peltonen L, Perola M, Price RA, Redline S, Srinivasan SR, Stern MP, Stone S, Stringham H, Turner S, Wijmenga C, Collier DA. Meta-analysis of genome-wide linkage studies in BMI and obesity. Obesity (

Silver Spring ). 2007 Sep;15(9):2263-75. PubMed PMID: 17890495.

8.  Lei SF, Jiang H, Deng FY, Deng HW. Searching for genes underlying susceptibility to osteoporotic fracture: current progress and future prospect. Osteoporos Int. 2007 Sep;18(9):1157-75. Review. PubMed PMID: 17534537.

9.  Liu J, Liu Y, Liu X, Deng HW. Bayesian mapping of quantitative trait loci for multiple complex traits with the use of variance components. Am J Hum Genet. 2007 Aug;81(2):304-20. Epub 2007 Jul 3. PubMed PMID: 17668380; PubMed Central PMCID: PMC1950806.

10.  Jiang H, Xiong DH, Guo YF, Shen H, Xiao P, Yang F, Chen Y, Zhang F, Recker RR, Deng HW. Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families. Int J Obes (Lond). 2007 Aug;31(8):1319-24. PubMed PMID: 17342072.

11.  Chen Y, Xiong DH, Yang TL, Yang F, Jiang H, Zhang F, Shen H, Xiao P, Recker RR, Deng HW. Variations in RANK gene are associated with adult height in Caucasians. Am J Hum Biol. 2007 Jul-Aug;19(4):559-65. PubMed PMID: 17546619.

12.  Tang ZH, Xiao P, Lei SF, Deng FY, Zhao LJ, Deng HY, Tan LJ, Shen H, Xiong DH, Recker RR, Deng HW. A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. J Clin Endocrinol Metab. 2007 Jul;92(7):2751-7. Epub 2007 May 1. PubMed PMID: 17473065.

13.  Zhao J, Xiong DH, Guo Y, Yang TL, Recker RR, Deng HW. Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in Caucasian females. Hum Reprod. 2007 Jun;22(6):1789-94. Epub 2007 Mar 21. PubMed PMID: 17376820.

14.  Deng FY, Xiao P, Lei SF, Zhang L, Yang F, Tang ZH, Liu PY, Liu YJ, Recker RR, Deng HW. Bivariate whole genome linkage analysis for femoral neck geometric parameters and total body lean mass. J Bone Miner Res. 2007 Jun;22(6):808-16. PubMed PMID: 17352645.

15.  Wu S, Lei SF, Chen XD, Tan LJ, Jian WX, Deng FY, Sun X, Xiao SM, Jiang C, Guo YF, Zhu XZ, Deng HW. The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults. Ann Hum Biol. 2007 May-Jun;34(3):344-53. PubMed PMID: 17612864.

16.  Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, Deng HW. Relationship of obesity with osteoporosis. J Clin Endocrinol Metab. 2007 May;92(5):1640-6. Epub 2007 Feb 13. PubMed PMID: 17299077; PubMed Central PMCID: PMC1868430.

17.  Jiang DK, Xu FH, Liu MY, Chen XD, Li MX, Liu YJ, Shen H, Deng HW. No evidence of association of the osteocalcin gene HindIII polymorphism with bone mineral density in Chinese women. J Musculoskelet Neuronal Interact. 2007 Apr-Jun;7(2):149-54. PubMed PMID: 17627084.

18.  Liu J, Papasian C, Deng HW. Incorporating single-locus tests into haplotype cladistic analysis in case-control studies. PLoS Genet. 2007 Mar 23;3(3):e46. PubMed PMID: 17381242; PubMed Central PMCID: PMC1829402.

19.  Jiang H, Lei SF, Xiao SM, Chen Y, Sun X, Yang F, Li LM, Wu S, Deng HW. Association and linkage analysis of COL1A1 and AHSG gene polymorphisms with femoral neck bone geometric parameters in both Caucasian and Chinese nuclear families. Acta Pharmacol Sin. 2007 Mar;28(3):375-81. PubMed PMID: 17303000.

20.  Yang TL, Shen H, Xiong DH, Xiao P, Guo Y, Guo YF, Liu YZ, Recker RR, Deng HW. Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density. Ann Hum Genet. 2007 Mar;71(Pt 2):152-9. PubMed PMID: 17331078. 

21.  Yang F, Xiong DH, Guo Y, Shen H, Xiao P, Zhang F, Jiang H, Recker RR, Deng HW. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. Hum Genet. 2007 Mar;121(1):35-42. Epub 2006 Dec 5. PubMed PMID: 17146638; PubMed Central PMCID: PMC1829487.

22.  Zhao LJ, Xiao P, Liu YJ, Xiong DH, Shen H, Recker RR, Deng HW. A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families. Hum Genet. 2007 Mar;121(1):145-8. Epub 2006 Nov 7. PubMed PMID: 17115187.

23.  Xiong DH, Lei SF, Yang F, Wang L, Peng YM, Wang W, Recker RR, Deng HW. Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites. J Bone Miner Res. 2007 Mar;22(3):385-93. PubMed PMID: 17241106.

24.  Chen Y, Guo YF, Lei SF, Wang YB, Deng HW. Genetic and environmental correlations between bone mineral density and bone size in Caucasians. Hum Biol. 2007 Feb;79(1):15-24. PubMed PMID: 17985654.

25.  Ioannidis JP, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng HW, Econs MJ, Karasik D, Devoto M, Kammerer CM, Spector T, Andrew T, Cupples LA, Duncan EL, Foroud T, Kiel DP, Koller D, Langdahl B, Mitchell BD, Peacock M, Recker R, Shen H, Sol-Church K, Spotila LD, Uitterlinden AG, Wilson SG, Kung AW, Ralston SH. Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res. 2007 Feb;22(2):173-83. PubMed PMID: 17228994.

26.  Yang YJ, Wang YB, Lei SF, Long JR, Shen H, Zhao LJ, Jiang DK, Xiao SM, Chen XD, Chen Y, Deng HW. AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families. Eur J Epidemiol. 2007;22(8):527-32. Epub 2007 Jun 8. PubMed PMID: 17557141.

27.  Tan LJ, Lei SF, Chen XD, Liu MY, Guo YF, Xu H, Sun X, Jiang C, Xiao SM, Guo JJ, Yang YJ, Deng FY, Wang YB, Li YN, Zhu XZ, Deng HW. Establishment of peak bone mineral density in Southern Chinese males and its comparisons with other males from different regions of China. J Bone Miner Metab. 2007;25(2):114-21. Epub 2007 Feb 26. PubMed PMID: 17323181.

28.  Xiong D, Wang W, Chen Y, Jiang H, Deng HW. Genetic determination in onset age of wrist fracture. J Hum Genet. 2007;52(6):481-4. PubMed PMID:  17457512.


1.  Zhang F, Xiao P, Yang F, Shen H, Xiong DH, Deng HY, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. A whole genome linkage scan for QTLs underlying peak bone mineral density. Osteoporos Int. 2008 Mar;19(3):303-10. PubMed PMID: 17882466.

2.  Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, Deng HW. Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res. 2008 Jan;23(1):17-29. Review. PubMed PMID: 17784844; PubMed Central PMCID: PMC2663586.

3.  Yang TL, Chen XD, Guo Y, Lei SF, Wang JT, Zhou Q, Pan F, Chen Y, Zhang ZX, Dong SS, Xu XH, Yan H, Liu X, Qiu C, Zhu XZ, Chen T, Li M, Zhang H, Zhang L,  Drees BM, Hamilton JJ, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW.  Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. Am J Hum Genet. 2008 Dec;83(6):663-74. PubMed PMID: 18992858; PubMed Central PMCID: PMC2667994.

4.  Wang JT, Guo Y, Yang TL, Xu XH, Dong SS, Li M, Li TQ, Chen Y, Deng HW.  Polymorphisms in the estrogen receptor genes are associated with hip fractures in Chinese. Bone. 2008 Nov;43(5):910-4. Epub 2008 Jul 15. PubMed PMID: 18678289.

5.  Deng FY, Liu YZ, Li LM, Jiang C, Wu S, Chen Y, Jiang H, Yang F, Xiong JX, Xiao P, Xiao SM, Tan LJ, Sun X, Zhu XZ, Liu MY, Lei SF, Chen XD, Xie JY, Xiao GG, Liang SP, Deng HW. Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. Proteomics.  2008 Oct;8(20):4259-72. PubMed PMID: 18924182; PubMed Central PMCID: PMC2760933.

6.  Zhao LJ, Xiong DH, Pan F, Liu XG, Recker RR, Deng HW. Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families. Hum Genet. 2008 Sep;124(2):171-7. Epub 2008 Aug 7. PubMed PMID: 18685868.

7.  Zhang J, Li J, Deng H. Class-specific correlations of gene expressions:  identification and their effects on clustering analyses. Am J Hum Genet. 2008 Aug;83(2):269-77. PubMed PMID: 18674746; PubMed Central PMCID: PMC2495058.

8.  Liu YJ, Liu XG, Wang L, Dina C, Yan H, Liu JF, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Meyre D, Delplanque J, Pei YF, Zhang L, Recker RR, Froguel P, Deng HW. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.  Hum Mol Genet. 2008 Jun 15;17(12):1803-13. Epub 2008 Mar 5. PubMed PMID:  18325910; PubMed Central PMCID: PMC2900891.

9.  He LN, Liu YJ, Xiao P, Zhang L, Guo Y, Yang TL, Zhao LJ, Drees B, Hamilton J, Deng HY, Recker RR, Deng HW. Genome wide linkage scan for combined obesity phenotypes using principal component analysis. Ann Hum Genet. 2008 May;72(Pt  3):319-26. Epub 2008 Jan 6. PubMed PMID: 18261184.

10.  Pan F, Xiao P, Guo Y, Liu YJ, Deng HY, Recker RR, Deng HW. Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density. Hum Genet. 2008 May;123(4):419-27. Epub 2008 Apr 1. PubMed PMID: 18379822.

11.  Xiao P, Chen Y, Jiang H, Liu YZ, Pan F, Yang TL, Tang ZH, Larsen JA, Lappe JM, Recker RR, Deng HW. In vivo genome-wide expression study on human circulating B cells suggests a novel ESR1 and MAPK3 network for postmenopausal osteoporosis. J Bone Miner Res. 2008 May;23(5):644-54. PubMed PMID: 18433299; PubMed Central PMCID: PMC2674539.

12.  Wang XL, Deng FY, Tan LJ, Deng HY, Liu YZ, Papasian CJ, Recker RR, Deng HW.  Bivariate whole genome linkage analyses for total body lean mass and BMD. J Bone Miner Res. 2008 Mar;23(3):447-52. PubMed PMID: 17967140; PubMed Central PMCID:  PMC2669157.

13.  Peng YM, Lei SF, Guo Y, Xiong DH, Yan H, Wang L, Guo YF, Deng HW.  Sex-specific association of the glucocorticoid receptor gene with extreme BMD. J Bone Miner Res. 2008 Feb;23(2):247-52. PubMed PMID: 17937535; PubMed Central PMCID: PMC2665695.

14.  Zhang F, Liu J, Chen J, Deng HW. HAPSIMU: a genetic simulation platform for population-based association studies. BMC Bioinformatics. 2008 Aug 5;9:331. PubMed PMID: 18681963; PubMed Central PMCID: PMC2518933.

15.  Liu YZ, Wilson SG, Wang L, Liu XG, Guo YF, Li J, Yan H, Deloukas P, Soranzo N, Chinappen-Horsley U, Cervino A, Williams FM, Xiong DH, Zhang YP, Jin TB, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Spector TD, Deng HW.  Identification of PLCL1 gene for hip bone size variation in females in a genome-wide association study. PLoS One. 2008 Sep 8;3(9):e3160. PubMed PMID: 18776929; PubMed Central PMCID: PMC2522269.

16.  Zhang F, Wang Y, Deng HW. Comparison of population-based association stud methods correcting for population stratification. PLoS One. 2008;3(10):e3392.  Epub 2008 Oct 14. PubMed PMID: 18852890; PubMed Central PMCID: PMC2562035.

17.  Pei YF, Zhang L, Deng HW, Dvornyk V. CYP17 MspA1 polymorphism and age at menarche: a meta-analysis. Dis Markers. 2008;25(2):87-95. PubMed PMID: 18957719; PubMed Central PMCID: PMC2748958.

18.  Pei YF, Li J, Zhang L, Papasian CJ, Deng HW. Analyses and comparison of accuracy of different genotype imputation methods. PLoS One. 2008;3(10):e3551.  Epub 2008 Oct 29. PubMed PMID: 18958166; PubMed Central PMCID: PMC2569208.

19.  Liu YJ, Papasian CJ, Liu JF, Hamilton J, Deng HW. Is replication the gold standard for validating genome-wide association findings? PLoS One.  2008;3(12):e4037. Epub 2008 Dec 29. PubMed PMID: 19112512; PubMed Central PMCID: PMC2605260.


1.  Liu J, Pei Y, Papasian CJ, Deng HW. Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations. Genet Epidemiol. 2009 Apr;33(3):217-27. PubMed PMID: 18924135; PubMed Central PMCID: PMC2745071.

2.  Sha BY, Yang TL, Zhao LJ, Chen XD, Guo Y, Chen Y, Pan F, Zhang ZX, Dong SS, Xu XH, Deng HW. Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population. J Hum Genet. 2009 Apr;54(4):199-202. Epub 2009 Feb 20. PubMed PMID: 19229253; PubMed Central PMCID:  PMC2733232.

3.  Zhang L, Pei YF, Li J, Papasian CJ, Deng HW. Univariate/multivariate genome-wide association scans using data from families and unrelated samples.  PLoS One. 2009 Aug 4;4(8):e6502. PubMed PMID: 19652719; PubMed Central PMCID:  PMC2715864.

4.  Liu YZ, Pei YF, Liu JF, Yang F, Guo Y, Zhang L, Liu XG, Yan H, Wang L, Zhang YP, Levy S, Recker RR, Deng HW. Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. PLoS One. 2009 Aug 28;4(8):e6827. PubMed PMID: 19714249; PubMed Central PMCID: PMC2730014.

5.  Zhang L, Bonham AJ, Li J, Pei YF, Chen J, Papasian CJ, Deng HW. Family-based bivariate association tests for quantitative traits. PLoS One. 2009 Dec 2;4(12):e8133. PubMed PMID: 19956578; PubMed Central PMCID: PMC2779861.

6.  Zhang J, Li J, Deng HW. Identifying gene interaction enrichment for gene expression data. PLoS One. 2009 Nov 30;4(11):e8064. PubMed PMID: 19956614; PubMed Central PMCID: PMC2779493.

7.  Li J, Yang T, Wang L, Yan H, Zhang Y, Guo Y, Pan F, Zhang Z, Peng Y, Zhou Q, He L, Zhu X, Deng H, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Cheng J, Deng HW. Whole genome distribution and ethnic differentiation of copy number variation in Caucasian and Asian populations. PLoS One. 2009 Nov 23;4(11):e7958. PubMed PMID: 19956714; PubMed Central PMCID: PMC2776354.

8.  Guo YF, Li J, Chen Y, Zhang LS, Deng HW. A new permutation strategy of pathway-based approach for genome-wide association study. BMC Bioinformatics.  2009 Dec 18;10:429. PubMed PMID: 20021635; PubMed Central PMCID: PMC2809078.

9.  Yang R, Wang X, Li J, Deng H. Bayesian robust analysis for genetic architecture of quantitative traits. Bioinformatics. 2009 Apr 15;25(8):1033-9.  Epub 2008 Oct 30. PubMed PMID: 18974168; PubMed Central PMCID: PMC2666810.

10.  Zhang ZX, Lei SF, Deng FY, Zhang F, Liu YJ, Recker RR, Papasian CJ, Deng HW.  Bivariate genome-wide linkage analysis for traits BMD and AAM: effect of menopause on linkage signals. Maturitas. 2009 Jan 20;62(1):16-20. Epub 2008 Nov 18. PubMed PMID: 19019586.

11.  Lei SF, Yang TL, Tan LJ, Chen XD, Guo Y, Guo YF, Zhang L, Liu XG, Yan H, Pan   F, Zhang ZX, Peng YM, Zhou Q, He LN, Zhu XZ, Cheng J, Liu YZ, Papasian CJ, Deng HW. Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. Hum Genet. 2009 Feb;125(1):1-9. Epub 2008 Nov 23. PubMed PMID:  19030899; PubMed Central PMCID: PMC2730511.

12.  Liu YZ, Guo YF, Wang L, Tan LJ, Liu XG, Pei YF, Yan H, Xiong DH, Deng FY, Yu   N, Zhang YP, Zhang L, Lei SF, Chen XD, Liu HB, Zhu XZ, Levy S, Papasian CJ, Drees BM, Hamilton JJ, Recker RR, Deng HW. Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. PLoS Genet. 2009 Mar;5(3):e1000420. Epub 2009 Mar 13. PubMed PMID: 19282985; PubMed Central PMCID:  PMC2652107.

13.  Liu XG, Tan LJ, Lei SF, Liu YJ, Shen H, Wang L, Yan H, Guo YF, Xiong DH, Chen XD, Pan F, Yang TL, Zhang YP, Guo Y, Tang NL, Zhu XZ, Deng HY, Levy S, Recker RR,  Papasian CJ, Deng HW. Genome-wide association and replication studies identified TRHR as an important gene for lean body mass. Am J Hum Genet. 2009 Mar;84(3):418-23. Epub 2009 Mar 5. PubMed PMID: 19268274; PubMed Central PMCID:  PMC2668008.

14.  Xiong DH, Liu XG, Guo YF, Tan LJ, Wang L, Sha BY, Tang ZH, Pan F, Yang TL, Chen XD, Lei SF, Yerges LM, Zhu XZ, Wheeler VW, Patrick AL, Bunker CH, Guo Y, Yan H, Pei YF, Zhang YP, Levy S, Papasian CJ, Xiao P, Lundberg YW, Recker RR, Liu YZ, Liu YJ, Zmuda JM, Deng HW. Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups. Am J Hum Genet. 2009 Mar;84(3):388-98. Epub 2009 Feb 26. PubMed PMID: 19249006; PubMed Central PMCID: PMC2667986.

15.  Yan H, Liu YJ, Zhou Q, Xiao P, Recker RR, Deng HW. Comparison of whole genome linkage scans in premenopausal and postmenopausal women: no bone-loss-specific QTLs were implicated. Osteoporos Int. 2009 May;20(5):771-7. Epub 2008 Sep 3.  PubMed PMID: 18766293.

16.  Lei SF, Tan LJ, Liu XG, Wang L, Yan H, Guo YF, Liu YZ, Xiong DH, Li J, Yang TL, Chen XD, Guo Y, Deng FY, Zhang YP, Zhu XZ, Levy S, Papasian CJ, Hamilton JJ, Recker RR, Deng HW. Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. Hum Mol Genet. 2009 May 1;18(9):1661-9. Epub 2008 Nov 27. PubMed PMID: 19039035; PubMed Central PMCID: PMC2667283.

17.  Guo Y, Li J, Bonham AJ, Wang Y, Deng H. Gains in power for exhaustive analyses of haplotypes using variable-sized sliding window strategy: a comparison of association-mapping strategies. Eur J Hum Genet. 2009 Jun;17(6):785-92. Epub 2008 Dec 17. PubMed PMID: 19092774; PubMed Central PMCID: PMC2746379.

18.  Pei YF, Zhang L, Liu J, Deng HW. Multivariate association test using haplotype trend regression. Ann Hum Genet. 2009 Jul;73(Pt 4):456-64. Epub 2009 Jun 1. PubMed PMID: 19489754; PubMed Central PMCID: PMC2741021.

19.  Liu YZ, Pei YF, Guo YF, Wang L, Liu XG, Yan H, Xiong DH, Zhang YP, Levy S, Li J, Haddock CK, Papasian CJ, Xu Q, Ma JZ, Payne TJ, Recker RR, Li MD, Deng HW. Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15. Mol Psychiatry. 2009 Jul;14(7):668-80. Epub 2009 Feb 3. PubMed PMID: 19188921; PubMed Central PMCID: PMC2700850.

20.  Dong SS, Liu XG, Chen Y, Guo Y, Wang L, Zhao J, Xiong DH, Xu XH, Recker RR, Deng HW. Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians. Calcif Tissue Int. 2009   Aug;85(2):104-12. Epub 2009 May 21. PubMed PMID: 19458885; PubMed Central PMCID: PMC2916082.

21.  De Moor MH, Liu YJ, Boomsma DI, Li J, Hamilton JJ, Hottenga JJ, Levy S, Liu XG, Pei YF, Posthuma D, Recker RR, Sullivan PF, Wang L, Willemsen G, Yan H, De Geus EJ, Deng HW. Genome-wide association study of exercise behavior in Dutch and American adults. Med Sci Sports Exerc. 2009 Oct;41(10):1887-95. PubMed PMID:  19727025; PubMed Central PMCID: PMC2895958.

22.  Zhang F, Zhang L, Deng HW. A PCA-based method for ancestral informative markers selection in structured populations. Sci China C Life Sci. 2009 Oct;52(10):972-6. Epub 2009 Nov 13. PubMed PMID: 19911134; PubMed Central PMCID: PMC2920624.

23.  Zhang L, Li J, Pei YF, Liu Y, Deng HW. Tests of association for quantitative traits in nuclear families using principal components to correct for population stratification. Ann Hum Genet. 2009 Nov;73(Pt 6):601-13. Epub 2009 Aug 20. PubMed PMID: 19702646; PubMed Central PMCID: PMC2764806.

24.  Yang F, Tang Z, Deng H. Bivariate association analysis for quantitative traits using generalized estimation equation. J Genet Genomics. 2009 Dec;36(12):733-43. PubMed PMID: 20129400.

25.  Zhang L, Liu J, Deng HW. A multilocus linkage disequilibrium measure based on mutual information theory and its applications. Genetica. 2009 Dec;137(3):355-64.  Epub 2009 Aug 26. PubMed PMID: 19707879.


1.  Zhang L, Pei YF, Li J, Papasian CJ, Deng HW. Efficient utilization of rare variants for detection of disease-related genomic regions. PLoS One. 2010 Dec 10;5(12):e14288. PubMed PMID: 21170328; PubMed Central PMCID: PMC3000820.

2.  Zhang L, Pei YF, Li J, Papasian CJ, Deng HW. Improved detection of rare genetic variants for diseases. PLoS One. 2010 Nov 8;5(11):e13857. PubMed PMID:  21079782; PubMed Central PMCID: PMC2975623.

3.  Pan F, Yang TL, Chen XD, Chen Y, Gao G, Liu YZ, Pei YF, Sha BY, Jiang Y, Xu C, Recker RR, Deng HW. Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. Immunogenetics. 2010 Apr;62(4):237-51. Epub 2010 Mar 9. PubMed PMID: 20217071; PubMed Central PMCID: PMC2925024.

4.  Zhang F, Deng HW. Correcting for cryptic relatedness in population-based association studies of continuous traits. Hum Hered. 2010;69(1):28-33. Epub 2009 Oct 2. PubMed PMID: 19797906; PubMed Central PMCID: PMC2880733.

5.  Deng FY, Zhao LJ, Pei YF, Sha BY, Liu XG, Yan H, Wang L, Yang TL, Recker RR, Papasian CJ, Deng HW. Genome-wide copy number variation association study suggested VPS13B gene for osteoporosis in Caucasians. Osteoporos Int. 2010 Apr;21(4):579-87. Epub 2009 Aug 13. Erratum in: Osteoporos Int. 2010 Aug;21(8):1455. PubMed PMID: 19680589; PubMed Central PMCID: PMC2924432.

6.  Guo Y, Tan LJ, Lei SF, Yang TL, Chen XD, Zhang F, Chen Y, Pan F, Yan H, Liu X, Tian Q, Zhang ZX, Zhou Q, Qiu C, Dong SS, Xu XH, Guo YF, Zhu XZ, Liu SL, Wang XL, Li X, Luo Y, Zhang LS, Li M, Wang JT, Wen T, Drees B, Hamilton J, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet. 2010 Jan 8;6(1):e1000806. PubMed PMID: 20072603; PubMed Central PMCID:  PMC2794362.

7.  Liu P, Lu Y, Recker RR, Deng HW, Dvornyk V. ALOX12 gene is associated with the onset of natural menopause in white women. Menopause. 2010 Jan-Feb;17(1):152-6. PubMed PMID: 20061896; PubMed Central PMCID: PMC2927106.

8.  Yang TL, Guo Y, Zhang LS, Tian Q, Yan H, Guo YF, Deng HW. HMGA2 is confirmed to be associated with human adult height. Ann Hum Genet. 2010 Jan;74(1):11-6. Epub 2009 Nov 20. PubMed PMID: 19930247; PubMed Central PMCID: PMC2972475.

9.  Liu YJ, Guo YF, Zhang LS, Pei YF, Yu N, Yu P, Papasian CJ, Deng HW. Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity. Obesity (Silver Spring). 2010 Dec;18(12):2339-46. Epub 2010 Apr 8. PubMed PMID: 20379146; PubMed Central PMCID: PMC2980805.

10.  Li X, Tan L, Liu X, Lei S, Yang T, Chen X, Zhang F, Fang Y, Guo Y, Zhang L, Yan H, Pan F, Zhang Z, Peng Y, Zhou Q, He L, Zhu X, Cheng J, Zhang L, Liu Y, Tian Q, Deng H. A genome wide association study between copy number variation (CNV) and human height in Chinese population. J Genet Genomics. 2010 Dec;37(12):779-85.  PubMed PMID: 21193156.

11.  Zhang F, Deng HW. Confounding from cryptic relatedness in haplotype-based association studies. Genetica. 2010 Oct;138(9-10):945-50. Epub 2010 Aug 1. PubMed PMID: 20680405.

12.  Yu N, Liu YJ, Pei Y, Zhang L, Lei S, Kothari NR, Li DY, Papasian CJ, Hamilton J, Cai JQ, Deng HW. Evaluation of compressive strength index of the femoral neck in Caucasians and Chinese. Calcif Tissue Int. 2010 Oct;87(4):324-32. Epub 2010 Sep 3. PubMed PMID: 20814670.

13.  Tan L, Liu R, Lei S, Pan R, Yang T, Yan H, Pei Y, Yang F, Zhang F, Pan F, Zhang Y, Hu H, Levy S, Deng H. A genome-wide association analysis implicates SOX6 as a candidate gene for wrist bone mass. Sci China Life Sci. 2010 Sep;53(9):1065-72. Epub 2010 Nov 23. PubMed PMID: 21104366.

14.  Xu XH, Dong SS, Guo Y, Yang TL, Lei SF, Papasian CJ, Zhao M, Deng HW. Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Endocr Rev. 2010 Aug;31(4):447-505. Epub 2010 Mar 31. Review. PubMed PMID: 20357209.

15.  Yang TL, Guo Y, Zhang LS, Tian Q, Yan H, Papasian CJ, Recker RR, Deng HW. Runs of homozygosity identify a recessive locus 12q21.31 for human adult height. J Clin Endocrinol Metab. 2010 Aug;95(8):3777-82. Epub 2010 May 13. PubMed PMID: 20466785; PubMed Central PMCID: PMC2913044.

16.  Zhang F, Tan LJ, Lei SF, Deng HW. The differences of femoral neck geometric parameters: effects of age, gender and race. Osteoporos Int. 2010 Jul;21(7):1205-14. Epub 2009 Oct 3. PubMed PMID: 19802512; PubMed Central PMCID: PMC2921984.

17.  Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V, Mikkelsen JD, Thirstrup K, Larsen LK, Cullberg KB, Fahrenkrug J, Jacobson P, Carlsson LM, Liu Y, Liu X, Deng HW, Larsen PJ. The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring). 2010 Jul;18(7):1289-96. Epub 2009 Oct 22. PubMed PMID: 19851307; PubMed Central PMCID: PMC2921166.

18.  Zhang L, Guo YF, Liu YZ, Liu YJ, Xiong DH, Liu XG, Wang L, Yang TL, Lei SF, Guo Y, Yan H, Pei YF, Zhang F, Papasian CJ, Recker RR, Deng HW. Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD. J Bone Miner Res. 2010 Jul;25(7):1572-80. PubMed PMID: 20200951.

19.  Pan F, Liu XG, Guo YF, Chen Y, Dong SS, Qiu C, Zhang ZX, Zhou Q, Yang TL, Guo Y, Zhu XZ, Deng HW. The regulation-of-autophagy pathway may influence Chinese stature variation: evidence from elder adults. J Hum Genet. 2010 Jul;55(7):441-7. Epub 2010 May 7. PubMed PMID: 20448653; PubMed Central PMCID: PMC2923432.

20.  Zhang YP, Deng FY, Chen Y, Pei YF, Fang Y, Guo YF, Guo X, Liu XG, Zhou Q, Liu YJ, Deng HW. Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening. Osteoporos Int. 2010 May;21(5):785-95. Epub 2009 Jul 24. PubMed PMID: 19629617; PubMed Central PMCID: PMC2917903.

21.  Pi M, Zhang L, Lei SF, Huang MZ, Zhu W, Zhang J, Shen H, Deng HW, Quarles LD. Impaired osteoblast function in GPRC6A null mice. J Bone Miner Res. 2010 May;25(5):1092-102. PubMed PMID: 19874200.

22.  Guo Y, Zhang LS, Yang TL, Tian Q, Xiong DH, Pei YF, Deng HW. IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. J Bone Miner Res. 2010 May;25(5):1042-8. PubMed PMID: 19874204.

23.  Chen XD, Xiao P, Lei SF, Liu YZ, Guo YF, Deng FY, Tan LJ, Zhu XZ, Chen FR, Recker RR, Deng HW. Gene expression profiling in monocytes and SNP association suggest the importance of the STAT1 gene for osteoporosis in both Chinese and Caucasians. J Bone Miner Res. 2010 Feb;25(2):339-55. PubMed PMID: 19594299.

24.  Zhao LJ, Liu XG, Liu YZ, Liu YJ, Papasian CJ, Sha BY, Pan F, Guo YF, Wang L, Yan H, Xiong DH, Tang ZH, Yang TL, Chen XD, Guo Y, Li J, Shen H, Zhang F, Lei SF, Recker RR, Deng HW. Genome-wide association study for femoral neck bone geometry. J Bone Miner Res. 2010 Feb;25(2):320-9. PubMed PMID: 20175129.

25.  Xu XH, Xiong DH, Liu XG, Guo Y, Chen Y, Zhao J, Recker RR, Deng HW.  Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families. Osteoporos Int. 2010 Jan;21(1):99-107. Epub 2009 Jun 19. PubMed PMID: 19543766; PubMed Central PMCID: PMC2914268.

26.  Liu P, Lu Y, Recker RR, Deng HW, Dvornyk V. Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women. Menopause. 2010 Jan-Feb;17(1):185-90. PubMed PMID: 19593234; PubMed Central PMCID: PMC2806497.

27.  Chen Y, Xiong DH, Guo YF, Pan F, Zhou Q, Zhang F, Deng HW. Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry. Bone. 2010 Jan;46(1):129-36. PubMed PMID: 19786129; PubMed Central PMCID: PMC2818219.


1.  Zhang Y, Papasian CJ, Deng HW. Alteration of vitamin D metabolic enzyme expression and calcium transporter abundance in kidney involved in type 1 diabetes-induced bone loss. Osteoporos Int. 2011 Jun;22(6):1781-8. PubMed PMID: 20878391.

2.  Chen Y, Liu YJ, Pei YF, Yang TL, Deng FY, Liu XG, Li DY, Deng HW. Copy number variations at the Prader-Willi Syndrome region on chromosome 15 and associations with obesity in whites. Obesity (

Silver Spring ). 2011 Jun;19(6):1229-34. Epub 2011 Jan 13. PubMed PMID: 21233802.

3.  Lei SF, Papasian CJ, Deng HW. Polymorphisms in predicted miRNA binding sites and osteoporosis. J Bone Miner Res. 2011 Jan;26(1):72-8. PubMed PMID: 20641033.

4.  Zhang F, Guo X, Deng HW. Multilocus association testing of quantitative traits based on partial least-squares analysis. PLoS One. 2011 Feb 3;6(2):e16739. PubMed PMID: 21304821; PubMed Central PMCID: PMC3033421.

5.  Deng FY, Lei SF, Chen XD, Tan LJ, Zhu XZ, Deng HW. An integrative study ascertained SOD2 as a susceptibility gene for osteoporosis in Chinese. J Bone Miner Res. 2011 Jul 19. [Epub ahead of print] PMID: 21773993.

6.  Deng FY, Lei SF, Zhang Y, Zhang YL, Zheng YP, Zhang LS, Pan R, Wang L, Tian Q, Shen H, Zhao M, Lundberg WY, Liu YZ, Papasian CJ, Deng HW. Peripheral Blood Monocyte-Expressed Anxa2 Gene Is Involved in Pathogenesis of Osteoporosis in Humans. Mol Cell Proteomics. 2011 Aug 4 PMID: 21817168.

7.  Lu Y, Liu YZ, Liu PY, Dvornyk V, Deng HW. A bootstrap-based regression method for comprehensive discovery of differential gene expressions: An application to the osteoporosis study.Eur J Med Genet. 2011 Jul 30. [Epub ahead of print] PMID: 1843665.

8.  Liu SL, Lei SF, Yang F, Li X, Liu R, Nie S, Liu XG, Yang TL, Guo Y, Deng FY, Tian Q, Li J, Liu YZ, Liu YJ, Shen H, Deng HW. Copy Number Variation in CNP267 Region May Be Associated with Hip Bone Size.Guo Y, Yang TL, Liu YZ, Shen H, Lei SF, Yu N, Chen J, Xu T, Cheng Y, Tian Q, Yu P, Deng HW. Mitochondria-wide association study of common variants in osteoporosis.Ann Hum Genet. 2011 Sep;75(5):569-74. PMID: 21762117 PMCID: PMC3155639.

9.  Zhang YP, Liu YZ, Guo Y, Liu XG, Xu XH, Guo YF, Chen Y, Zhang F, Pan F, Zhu XZ, Deng HW. Pathway-Based Association Analyses Identified TRAIL Pathway for Osteoporotic Fractures.PLoS One.2011;6(7):e21835. Epub 2011 Jul 8. PMID: 21760914 PMCID: PMC3132733.

10.  Tan LJ, Liu SL, Lei SF, Papasian CJ, Deng HW. Molecular genetic studies of gene identification for sarcopenia.  Hum Genet. 2011 Jun 26. [Epub ahead of print] PMID:21706341.

11.  Zhang R, Edwards JR, Ko SY, Dong S, Liu H, Oyajobi BO, Papasian C, Deng HW, Zhao M. Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts. PLoS One. 2011;6(6):e20780. Epub 2011 Jun 9. PMID: 21695256 PMCID: PMC3111437.

12.  Li GH, Deng HW, Kung AW, Huang QY. Identification of genes for bone mineral density variation by computational disease gene identification strategy. J Bone Miner Metab. 2011 Jun 3. [Epub ahead of print] PMID: 21638018.

13.  Lin Y, Li J, Shen H, Zhang L, Papasian CJ, Deng HW. Comparative studies of de novo assembly tools for next-generation sequencing technologies. Bioinformatics. 2011 Aug 1;27(15):2031-7. Epub 2011 Jun 2. PMID:21636596.

14.  Yang TL, Guo Y, Liu YJ, Shen H, Liu YZ, Lei SF, Li J, Tian Q, Deng HW. Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations. Osteoporos Int. 2011 Apr 6. [Epub ahead of print] PMID: 21625884.

15.  Liu H, Zhang R, Ko SY, Oyajobi BO, Papasian CJ, Deng HW, Zhang S, Zhao M. Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: Stathmin deficiency produces an osteopenic phenotype in mice. J Bone Miner Res. 2011 Sep;26(9):2052-67. doi: 10.1002/jbmr.419. PMID:21557310.

16.  Sheng J, Deng HW, Calhoun V, Wang YP. Integrated Analysis of Gene Expression and Copy Number Data on Gene Shaving using Independent Component Analysis. IEEE/ACM Trans Comput Biol Bioinform. 2011 Apr 14. [Epub ahead of print] PMID: 21519112.

17.  Yang TL, Guo Y, Shen H, Lei SF, Liu YJ, Li J, Liu YZ, Yu N, Chen J, Xu T, Cheng Y, Tian Q, Yu P, Papasian CJ, Deng HW. Genetic association study of common mitochondrial variants on body fat mass. PLoS One. 2011;6(6):e21595. Epub 2011 Jun 29. PMID: 21747914.


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