GEHS 6600 - Principles of Toxicology, 3 credits
Prerequisites: Some knowledge of biology and chemistry is desirable to the principles of mammalian toxicology. Exposure, dose-response, kinetics and distribution of toxicants, metabolism of toxic agents, factors that affect toxicity, introductory chemical carcinogenesis are discussed.
Course Learning Objectives
The student will be able to:
- Explain the impact of the conditions of exposure – routes, duration and frequency on the toxic effects of compounds.
- Explain and interpret the relationship between dose and the toxic response.
- Describe the processes of absorption, distribution, storage and excretion and apply the principles of toxicant transport across membranes to the uptake, action and excretion of chemical agents.
- Describe and characterize the types of reactions in Phase I and Phase II metabolic pathways and give prototypical examples of each.
- Compare and contrast 0 order and 1st order toxicokinetics and illustrate the impact of each on the toxicity of prototypical chemical agents.
- For each target organ discuss (liver, kidney, lung, nervous system and blood), explain and characterize the mechanisms of injury and give examples of toxicants that cause the injury.
- Identify the acute and chronic effects of hydrocarbons, halogenated hydrocarbons, pesticides, and heavy metals, characterize their mechanisms of toxicity, and describe measures to preventive or decrease toxic effects.
- Apply toxicological principles to mechanism of action of prototypical agents an illustrate their use as a basis for environmental public health preventive actions.