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Tulane study shows family violence may leave genetic imprint on children

A new study from Tulane University finds that the more fractured families are by domestic violence or trauma, the more likely that children may bear the scars down to their DNA.

Researchers from the School of Medicine and the School of Public Health and Tropical Medicine discovered that children in homes affected by domestic violence, suicide, or the incarceration of a family member have significantly shorter telomeres, a cellular marker of aging, than those in stable households. The findings are published online in the latest issue of the journal Pediatrics.

Telomere

Telomeres are the caps at the end of
chromosomes that keep them from
shrinking when cells replicate.


Telomeres are the caps at the end of chromosomes that keep them from shrinking when cells replicate. Shorter telomeres are linked to higher risks for heart disease, obesity, cognitive decline, diabetes, mental illness, and poor health outcomes in adulthood. Researchers took genetic samples from 80 children ages 5 to 15 in New Orleans and interviewed parents about their home environments and exposures to adverse life events.

“Family-level stressors, such as witnessing a family member get hurt, created an environment that affected the DNA within the cells of the children,” said lead author Dr. Stacy Drury, director of the Behavioral and Neurodevelopmental Genetics Laboratory at Tulane. “The greater the number of exposures these kids had in life, the shorter their telomeres were – and this was after controlling for many other factors, including socioeconomic status, maternal education, parental age at conception, and the child’s age.”

Dr. Katherine Theall, principal investigator of the National Institutes of Health-supported research project and associate professor of global community health and behavioral science, lead the study with Drury. The study is one of the many interdisciplinary research projects taking place at the Tulane Stress and Environment Research Collaborative on Health Disparities, based out of the School of Public Health and Tropical Medicine.

The study found that gender moderated the impact of family instability. Traumatic family events were more detrimental to young girls as they were more likely to have shortened telomeres. There was also a surprising protective effect for boys: mothers who had achieved a higher level of education had a positive association with telomere length, but only in boys under 10.

Ultimately, the study suggests that the home environment is an important intervention target to reduce the biological impacts of adversity in the lives of young children, Drury said.

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June 16, 2014
Keith Brannon
kbrannon@tulane.edu

 

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