Microsporidia are emerging and re-emerging fungal parasites associated with opportunistic infections and disease in humans including persons with HIV, organ transplant recipients, malnourished children, and the elderly. Subclinical infections are common in otherwise healthy individuals, and infections are transmitted between humans and from animals. Our research utilizes murine and nonhuman primate models of microsporidiosis to study molecular epidemiology, immunology, pathophysiology, drug therapies, and diagnostic methods. We also collaborate with investigators to better understand the evolution of the microsporidia.
Over the past few years, our research began to transition to studies on the immunology of aging to develop a nonhuman primate model that can be applied to human aging. Markers of inflammation are being used to test predictions about healthy and less-healthy aging. This model is expected to become relevant for studies on resistance/susceptibility to infectious diseases and testing vaccine efficacy in the elderly.
Immunology and pathogenesis of microsporidiosis; immunology of aging using a nonhuman primate model
- Post-doctoral, New York University Medical Center, New York, New York
- PhD, University of Texas Southwestern Medical Center, Dallas, Texas
- MS, Western Kentucky University, Bowling Green, Kentucky
- BS, Denison University, Granville, Ohio
Professional Achievements and Memberships:
- Member of Microsporidiosis Working Group for the NIH-CDC-HIVMA/IDSA, "Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-infected Adults and the Companion Guideline for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Children"
- Editorial board member of Folia Parasitologica and PLoS One
- Member of the American Association of Immunologists
- Member of the American Society for Microbiology
View Dr. Didier's publications at her NCBI profile page.
Level of Instruction:
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