Charles A. Miller III, PhD
Associate Professor of Environmental Health Sciences
Tulane Cancer Center Program Member
Address: 1430 Tulane Ave., Box SL-29, New Orleans, LA 70112-2699
Dr. Miller received a Bachelor of Science degree in biology from the University of Alabama in Birmingham. He worked as a research associate in the Pharmacology and Biochemistry Departments and the Cancer Center at the University of Alabama in Birmingham, studying anti-malarial drug toxicity with Roy Mundy, chemical carcinogenesis with Awni Sarrif, colon cancer biology with Michael Brattain, and the immunology of natural killer cells with Toru Abo and Charles Balch. He joined Max Costa's laboratory and studied carcinogenic mechanisms of nickel and chromium compounds and earned a Doctor of Philosophy degree in Environmental Oncology from the Sackler School of Basic Medical Sciences of New York University. During this time he was the recipient of a fellowship from Shell Oil Company. His post-doctoral research was conducted in David Kowalski's laboratory at Roswell Park Cancer Institute. There he described several new DNA replication origins in yeast. He is presently an Associate Professor in the Environmental Health Sciences Department at Tulane University School of Public Health and Tropical Medicine. His research interests include understanding the regulation of the aryl hydrocarbon (dioxin) receptor by Hsp90 and co-chaperone proteins and understanding the effects of various ligands on this signaling pathway.
Vujcic M, Miller III CA, Kowalski D. Activation of silent replication origins at ARS elements near the HML locus in budding yeast. Mol Cell Biol, 19:6098-109, 1999.
Miller III CA, Umek RM, Kowalski D. The inefficient ribosomal DNA origin of Saccharomyces cerevisiae contains an ARS consensus sequence and a DNA unwinding element that are functionally compromised. Nucleic Acids Res, 27:3921-30, 1999.
Miller III CA. A human aryl hydrocarbon receptor signaling pathway constructed in yeast displays additive responses to ligand mixtures. Toxicol Appl Pharmacol, 160: 297-303,1999.
Adachi J, Mori Y, Matsui S, Takigami H, Fujino J, Kitagawa H, Miller III CA, Kato T, Saeki K, Matsuda T. Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J Biol Chem in press, 2001
Miller III CA. Tetratricopeptide repeat-containing proteins facilitate signaling by the human aryl hydrocarbon receptor-Arnt complex expressed in yeast, Submitted. Cox M, Miller III CA. Genetic evidence that the p23 co-chaperone regulates human dioxin receptor signaling in a yeast model system. Submitted.