Heather Machado, Ph.D.
Assistant Professor of Biochemistry and Molecular Biology
Tulane Cancer Center Program Member in the Signaling Program
Address: 1430 Tulane Ave., SL-43, New Orleans, LA 70112
Dr. Machado received her B.S. degree in biological sciences at the University of New Orleans in 1999. She earned a Ph.D. in molecular and cellular biology in 2005 from Tulane University School of Medicine, where she studied the molecular mechanisms that regulate trophoblast invasion and the consequences of cytomegalovirus infection during early pregnancy. In 2013, she completed her postdoctoral studies in the laboratory of Jeffrey M. Rosen at Baylor College of Medicine, where she focused on understanding the role normal and cancer stem cells in mammary gland development and in human breast cancer.She joined the Department of Biochemistry and Molecular Biology at Tulane School of Medicine in 2013, and is a member of the Center for Stem Cell Research and Regenerative Medicine. Dr. Machado's laboratory is interested in understanding how inflammatory cells and cancer stem cells interact to regulate the switch from premalignant to invasive breast cancer.
Sainz B, Carron E, Vallespinos M, Machado HL. (2016) Cancer stem cells and macrophages: implications in tumor biology and therapeutic strategies. Mediators of Inflammation; 2016: 9012369. (PMC4769767)
D'Errico GD, Machado HL* and Sainz B.* (2016) A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet. Clinical and Translational Medicine; 6(1):3 ePub ahead of print. (PMC5209322) *co-corresponding author
Machado H.L., Kittrell F.S., Edwards D., White A.N., Atkinson R.L., Rosen J.M., Medina D., and Lewis M.T. Separation by cell size enriches for mammary stem cell repopulation activity. (2013) Stem Cells Translational Medicine; 2(3):199-203. (PMC3659766)
Batts T.D., Machado H.L., Zhang Y., Creighton C.J., Li Y., and Rosen J.M. Stem cell antigen-1 (Sca1) regulates mammary tumor development and cell migration. (2011) PLoS One; 6(11):e27841. (PMC3226565)
Kittrell F.S., Carletti M.Z., Kerbawy S., Heestand J.C., Xian W., Zhang M., LaMarca H., Sonnenberg A., Rosen J.M., Medina D., and Behbod F. Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. (2011) Breast Cancer Research; 13(2):R41. (PMC3219204)
Visbal A.P., LaMarca H.L., Villanueva H., Toneff M.J., Li Y., Rosen J.M., and Lewis M.T. Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. (2011) Developmental Biology; 352 (1):116-27. (PMC3057274)
Long W., Yi P., Amazit L., LaMarca H.L., Kuma R., Mancini M.A., Tsai S.Y., Tsai M., O’Malley B.W. RC 3Δ4 mediates the interaction of EGFR with FAK to promote cancer cell migration and metastasis. (2010) Molecular Cell; 37: 321-332. (PMC2824333)
LaMarca H.L., Visbal A.P., Creighton C.J., Liu H., Zhang Y., Behbod F., and Rosen J.M. (2010). C/EBP regulates stem cell activity and specifies luminal cell fate in the mammary gland. (2010) Stem Cells; 28(3): 535-44. (PMC3006225)
Behbod F., Kittrell F.S., LaMarca H., Edwards D., Kerbawy S., Heestand J.C., Young E., Mukhopadhyay P., Yeh H., Allred D.C., Hi M., Polyak K., Rosen J.M., and Medina D. An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. (2009) Breast Cancer Research; 11(5):R66. (PMC2790841)
Coffelt S.B., Marini F.C., Watson K., Zwezdaryk K.J., Dembinski J.L., LaMarca H.L., Tomchuck S.L.,Höner zu Bentrup K., Danka E.S., Henkle S.L., and Scandurro A.B. The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells. (2009) Proc. Natl. Acad. Sci. USA; 106(10):3806-11. (PMC2656161)
LaMarca H.L. and Rosen J.M. Minireview: hormones and mammary cell fate—what will I become when I grow up? (2008). Endocrinology; 149(9):4317-21. (PMC2553372)
Coffelt S.B., Waterman R.S., Florez L., Höner zu Bentrup K., Zwezdaryk K.J., Tomchuck S.L., LaMarca H.L., Danka E.S., Morris C.A., and Scandurro A.B. (2008). Ovarian cancers overexpress the antimicrobial protein hCAP-18/LL-37 and the LL-37 peptide increases ovarian cancer cell proliferation and invasion. Int J Cancer; 122(5):1030-9.