Nancy E. Hopkins, PhD
Professor of Practice, Cell and Molecular Biology
Tulane Cancer Center Contributing Member
Address: 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118
Dr. Hopkins received her B.S. in chemistry from Auburn University in 1970 and an M.S. in clinical pathology from the University of Alabama at Birmingham in 1973. After teaching at Loyola University in New Orleans for several years, she entered the doctoral program in the Chemistry Department at Tulane University in the laboratory of Dr. William Alworth and received her Ph.D. in 1992. She moved to the laboratories of Dr. William George and Dr. Juan Lertora in the Pharmacology Department at Tulane University School of Medicine. Her research interests are centered on the role of cytochrome P450 in both carcinogenesis and cancer chemoprevention. She is also interested in the role of natural products that are chemo-preventive in breast and prostate cancer. In collaboration with Dr. Maryam Foroozesh at Xavier University, she studies the inhibition of cytochrome P450 and the Akt pathway by natural product analogs. Dr. Hopkins is a member of the American Association of Cancer Researchers, the American Chemical Society, and the American Society of Biochemistry and Molecular Biology. She is also an associate member of the Society of Toxicology. She is on the National Council of Iota Sigma Pi Women's Chemistry Honorary Society.
Hopkins NE, English N, Hughes V, Rowley CW, Wolf CR, Alworth WL. Induction of CYP 102 (cytochrome P450BM-3) in Bacillus megaterium by 17-beta estradiol and 4-sec-butylphenol. Biochem Biophys Res Commun, 244: 868-872, 1998.
Shimada T, Yamazaki H, Foroozesh M, Hopkins N, Alworth WL, Guengerich FP. Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Chem Res Toxicol, 11: 1048-1056, 1998.
Kobayashi Y, Stroble SM, Hopkins NE, Alworth WL, Halpert JR. Catalytic properties of an expressed cytochrome P450 2B1 from Wistar-Kyoto rat liver cDNA library. Drug Metab Dispos, 26: 1026-1030, 1998.
Nikov GN, Hopkins NE, Boue S, Alworth WI. Interactions of dietary estrogens with human estrogen receptors and the effect on estrogen receptor-estrogen response element complex formation. Environ Health Perspect, 108: 867-872, 2000.
Scott JF, Foroozesh M, Hopkins NE, Alekantis TG, Alworth WL. Inhibition of cytochrome P450 6D1 by alkylarenes, methylenedioxyarenes, and other substituted aromatics. Pestic Biochem Physiol, 67: 63-71, 2000.
Rowley CW, Rajnarayanan RV, Hopkins NE, Alworth WL. Differential expression of CYP102 in Bacillus megaterium by 17-beta-estradiol and 4-sec-butylphenol. Biochem Biophys Res Commun, 300: 102-6, 2003.