The People of Tulane Cancer Center Research

vp 2015

Victoria P Belancio, PhD

Associate Professor of Structural and Cellular Biology
Member of the Tulane Center for Aging
Tulane Cancer Center Program Member

Contact Information
Phone: 504-988-4506
Office Address:  1700 Tulane Ave., New Orleans, LA  70112 - Room 813
Mailing Address: 1430 Tulane Ave., Box SL-49, New Orleans, LA 70112-2699

Biographical Narrative
Dr. Belancio was born in Berlin, Germany. She obtained her BS and MS degrees in Cytology and Genetics from Novosibirsk State University in Novosibirsk, Russia. She studied Medical Genetics at the University of Alabama at Birmingham. She received her doctoral degree in Molecular and Cellular biology from the Department of Epidemiology at Tulane University in New Orleans. She did her postdoctoral training with Dr. Prescott Deininger at Tulane University. She has been a faculty member in the Department of Structural and Cellular Biology, Tulane School of Medicine since 2008 and is a member of the Tulane Center for Aging. Dr. Belancio’s primary research interests are focused on genetic instability and cellular responses associated with the activity of mammalian retroelements. She is studying molecular mechanisms controlling the expression of and the damage from these elements in normal and cancer cells.

Selected Publications
Wertz GW, Perepelitsa VP, Ball LA. Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus. Proc Natl Acad Sci U S A. Mar 31; 95(7):3501-6. 1998 PMID:9520395

Ball LA, Pringle CR, Flanagan B, Perepelitsa VP, Wertz GW. Phenotypic consequences of rearranging the P, M, and G genes of vesicular stomatitis virus. J Virology. Jun; 73(6):4705-12. 1999 PMID:10233930

Perepelitsa-Belancio V, Deininger P. RNA truncation by premature polyadenylation attenuates human mobile element activity. Nat Genetics. Dec; 35(4):363-6. 2003 PMID:14625551

Xing J., Wang H., Belancio VP., Cordaux R., Deininger P., and Batzer MA.. "Emergence of new primate genes by retrotransposon-mediated sequence transduction" Proc Natl Acad Sci USA. Nov 21;103(47):17608-13. 2006  PMID:17101974

Belancio VP., D. Hedges, and Deininger P. Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health. Genome Research. Mar;18(3):343-58 2008 PMID:18256243 

Belancio VP.*, Kroutter N.*, Wagstaff BJ., Roy-Engel AM. The RNA polymerase dictates ORF1 requirement and the timing of LINE and SINE retrotransposition. (* shared first authorship) Plos Genetics. Apr;5(4):e1000458. 2009 PMID:19390602

Belancio VP., Roy-Engel AM., Pochampally RR., and Deininger P. Somatic expression of  LINE-1 elements in human tissues. Nucleic Acids Research. Jul 1;38(12):3909-22, 2010 PMID:20215437

Belancio VP., Roy-Engel A., and Deininger. P. All y’all need to know ‘bout retroelements in cancer. Seminars in Cancer Biology. Aug;20(4):200-10 2010 PMID:20600922 [among most cited Seminars in Cancer Biology articles published since 2010]

Sokolowski M., deHaro D., Kines KJ., Christian C., Belancio VP. Characterization of self-interaction and cellular localization of L1 ORF1p using mammalian two hybrid system. PLoS ONE. December 8(12): e82021, 2013

Deharo DL., Kines KJ., Sokolowski M., Dauchy RT., Streva VA., Hill SM., Hanifin JP., Brainard GC., Blask DE., Belancio VP.  Regulation of L1 expression and retrotransposition by melatonin and its receptor; implications for cancer risk associated with light exposure at night. Nucleic Acids Research. Aug 1;42(12):7694-707, 2014

Kines KJ., Sokolowski M., Christian C., Deharo D., Belancio VP.  Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci. Nucleic Acids Research. Aug 20;42(16):10488-502 2014

Sokolowski M., deFreece C., Servant G., Kines KJ., Deharo DL., Belancio VP. Development of a monoclonal antibody specific to the endonuclease domain of the human LINE-1 ORF2. Mobile DNA Dec 10;5(1):29 2014

Belancio VP., Deininger P., Blask DE., Hill SM., Jazwinski SM. The Aging Clock and Circadian Control of Metabolism and Genome Stability. Frontiers in Genetics of Aging Jan 14;5:455 2015

Hill SM., Belancio VP., Dauchy RT., Brimmer S., Xiang S., Mao L., Hauch A., Lundberg P., Sommers W., Yuan L., Frash T., Blask DE. Melatonin an inhibitor of breast cancer. Journal of Endocrine Related Cancer, Jun;22(3):R183-204, 2015

Belancio VP.  LINE-1 activity as molecular basis for genomic instability associated with light exposure at night. Journal of Mobile Genetic Elements 2015

Xiang S., Dauchy RT., Hauch A., Mao L., Wren MA., Yuan L., Belancio VP., Mondal D., Frasch T., Blask DE., Hill SM. Doxorubicin Resistance in Breast Cancer is Driven by Light at Night-Induced Disruption of the Circadian Melatonin Signal. Journal of Pineal Research, Aug;59(1):60-9., 2015

Mao L., Dauchy RT., Blask DE., Slakey L., Zeringue S., Yuan L., Xiang S., Hauch A., Belancio VP., Dauchy EM., Hill SM. Melatonin suppression of aerobic glycolysis (Warburg effect), survival signaling, and metastasis in human leiomyosarcoma. Journal of Pineal Research, November 26, 2015

Click here to access complete list of publications.



1430 Tulane Ave, New Orleans, LA 70112