Zubaida Saifudeen, Ph.D.
Assistant Professor of Pediatrics - Nephrology
Tulane Cancer Center Contributing Member in the Genetics Program
Address: 1430 Tulane Ave., SL-37, New Orleans, LA 70112
Dr. Saifudeen graduated with a B.S. in Life Sciences from St. Xavier’s College, University of Bombay in 1987. After earning an M.S. in Molecular Biology from Northeastern University in Boston, MA in 1991, she moved to New Orleans and enrolled in the Interdepartmental Molecular and Cellular Biology Graduate Program at Tulane SOM. In line with her interest in transcription and cancer, and under the mentorship of Dr. Melanie Ehrlich in the Department of Biochemistry, her Ph.D. dissertation was on transcriptional regulation by methylated DNA binding proteins. Upon graduation in 1997, she started her post-doctoral training with Dr. Samir El-Dahr in Tulane's Department of Pediatrics. Her research involved transcriptional regulation of kidney development. She was appointed assistant professor in Pediatrics in 2005. During her training period, she received and was supported by an NRSA (2001-2004), followed by a National Kidney Foundation Young Investigator Grant (2005-2007) and the American Society of Nephrology Career Development Award (Carl W. Gottschalk Research Scholar) (2006-2008). From 2007-2012, she received funding as a Junior Investigator from the Hypertension COBRE (Dr. Navar, P.I.; Dr. El-Dahr, mentor). As indicated by her publications, Dr. Saifudeen's research continues to focus on kidney development, specifically on p53-regulated signaling and metabolic pathways in nephron progenitor cell self-renewal. Dissecting the function of a potent tumor-suppressor such as p53 in a normal physiological setting rather than in a pathophysiological one is of considerable clinical significance not only to renal disease but to cancer as well.
Saifudeen Z, Dipp S and El-Dahr SS. A Role for p53 in Terminal Epithelial Cell Differentiation. J. Clin. Invest. 109: 1021-1030, 2002.
Saifudeen Z, Marks J, Du H and El-Dahr SS. Spatial Repression of PCNA by p53 During Kidney Development. Am. J. Physiol. (Renal) 283: F727-F733, 2002.
Saifudeen Z, Dipp S, Fan H, and El-Dahr SS. Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4 and CBP: Implications for terminal nephron differentiation. Am. J. Physiol (Renal) 288: F899-F909, 2005.
Saifudeen Z, Diavolitsis V, Dipp S, Fan, H, and El-Dahr SS. Spatiotemporal switch from DNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression. J Biol Chem. 280: 23094 – 23102, 2005.
El-Dahr SS, Aboudehen K, Saifudeen Z. Transcriptional Control of Terminal Nephron Differentiation. Am J Physiol (Renal) 294(6):F1273-8, 2008. PMC2606293
Saifudeen Z, Dipp S, Stefkova J, Yao X, Lookabaugh S and El-Dahr SS. P53 Regulates Metanephric Development. J Am Soc Nephrol. 2009 Nov; 20(11):2328-37. PMC2799183
Saifudeen Z, Liu J, Dipp S, Yao X, Li Y, McLaughlin N, Aboudehen K, El-Dahr SS. A p53-Pax2 Pathway in Kidney Development: Implications for Nephrogenesis. PLoS One. 2012; 7(9):e44869. doi: 10.1371/journal.pone.0044869. PMID: 22984579
El-Dahr SS, Saifudeen Z. Interactions between BdkrB2 and p53 genes in the developing kidney. Biol Chem. 2013 Mar 394(3):347-51. PMID: 23152407
Li Y, Liu J, McLaughlin N, Bachvarov D, Saifudeen Z and El-Dahr SS. Genome-wide Analysis of the p53 Gene Regulatory Network in the Developing Mouse Kidney. Physiol Genomics. 2013 Sep 3. PMID: 24003036
El-Dahr SS, Hilliard S, Aboudehen K, Saifudeen Z. The MDM2-p53 pathway: multiple roles in kidney development. Pediatr Nephrol. 2013 Sep 28. PMID: 24077661