Prasad Katakam, MD, PhDPrasad V.G. Katakam, MD, PhD

Tulane University School of Medicine
Assistant Professor, Department of Pharmacology

Role of vascular insulin resistance in the complications of type 2 diabetes and obesity


Dr. Katakam is a physician scientist who received his medical training from Andhra University, India and clinical fellowship training in preventive cardiology at West Roxbury VA Medical Center-Harvard Medical School affiliate program. Following his clinical training, Dr. Katakam studied vascular dysfunction in diet-induced insulin resistance and type 2 diabetes as part of his doctoral research at The University of Georgia, Athens. Dr. Katakam continued his postdoctoral research studying mechanisms of vascular insulin resistance at the University of Iowa, the Mayo Clinic, and Wake Forest University. In 2011, Dr. Katakam was recruited as an Assistant Professor in the Department of Pharmacology at Tulane University School of Medicine. Dr. Katakam is member of the American Physiological Society, Microcirculation, and the American Heart Associations.

Ongoing research projects related to diabetes and obesity

Dr. Katakam has authored over 30 publications related to novel mechanisms underlying cardiovascular and cerebrovascular insulin resistance in models of type 2 diabetes and obesity. His present research employs techniques in microvascular function (confocal microcopy), free radical biology (electron spin resonance), bioenergetics (Seahorse XFe Analyzers), and Molecular Biology. Ongoing research projects include:

  • Hypoxia/Reoxygenation injury to endothelial cells and arteries. Studies examine the novel mechanisms involving nitric oxide synthase (NOS), endoplasmic reticulum (ER) and mitochondria by exposing cultured endothelial cells and isolated arteries to hypoxia/reoxygenation. Functional and morphological studies will determine the changes in mitochondrial calcium, ER-mitochondrial interorganelle communication, and cellular bioenergetics to understand how vascular cells respond to hypoxia/reoxygenation.
  • Vascular Mechanisms underlying Ischemia/Reperfusion injury to heart and brain. In vivo studies evaluate the role of novel vascular signaling pathways in animals exposed to ischemia-reperfusion injury of heart and brain. These studies are meant to complement the in vitro or ex vivo studies of hypoxia/reoxygenation in validating key observations related to cellular responses.
  • Vascular insulin resistance and type 2 diabetes and obesity. Studies examine the impact of insulin and glucose levels on responses to hypoxia/reoxygenation or ischemia/reperfusion injury in models of type 2 diabetes and obesity.

Lab members

Dan Liu, Research Assistant
Venkata N.L.R Sure, Graduate Student in Biomedical Sciences

Other Links

Research Gate

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