Hongju Wu PhD
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Hongju Wu, PhD
Associate Professor of Medicine
Phone: (504)-988-2153

Research Interests

My research interests involve two major human diseases—cancer and diabetes, and span from basic research to therapeutics development. My lab has expertise in biochemical, molecular, and cellular techniques. We use cell lines, primary cells (rat and human islets), and animal models (mouse and rats) in our studies.

In collaboration with other scientists in the field, I have completed multiple research projects in the past 8 years. With a record of success in securing research funding, my goal is to lead a laboratory standing at the frontier of research and to ensure this with continuous strong funding.

Selected Publications

Tang, Y., Han, T., Everts, M., Zhu, Z. B., Gillespie, G. Y., Curiel, D. T., and Wu, H. Directing Adenovirus across the blood brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model. Gene Ther. 2007 Mar;14(6):523-32. Epub 2006 Nov 30. PMID:17167498

Kolodkin-Gal, D., Zamir, G. Pikarski, E., Pikarski, A., Shimony, N., Wu, H., Haviv, Y. S., and Panet, A.  A novel system to study adenovirus tropism to normal and malignant colon tissues. Virology. 2007 Jan 5;357(1):91-101. Epub 2006 Sep 7. PMID:16962151

Van Houdt, W. J., Wu, H., Glasgow, J. N., Lamfers, M. L., Dirven, C. M., Gillespie, G. Y., Curiel, D. T., and Haviv, Y. S. Gene delivery into malignant glioma by infectivity-enhanced adenovirus: in vivo vs. in vitro Models. Neuro Oncol. 2007 Jul;9(3):280-90. Epub 2007 May 23. PMID:17522331

Han, T., Tang, Y., Ugai, H., Perry, L.E., Siegal G. P., Contreras, J. L., and Wu, H. Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy. Virol J. 2007 Oct 24;4:103. PMID:17958897

Saini, V., Martyshkin, D. V., Mirov, S. B., Perez, A., Perkins, G., Ellisman, M. H., Towner, V. D., Wu, H., Pereboeva, L., Borovjagin, A., Curiel, D. T., and Everts, M.  An adenoviral platform for selective self-assembly and targeted delivery of nanoparticles. Small. 2008 Feb;4(2):262-9. doi: 10.1002/smll.200700403. PMID:18200644

Tang, Y., Le, L. P., Matthews, Q. L., Han, T., Wu, H., and Curiel, D. T.  Derivation of a triple mosaic adenovirus based on modification of the minor capsid protein IX. Virology. 2008 Aug 1;377(2):391-400. doi: 10.1016/j.virol.2008.04.023. PMID:18570971

Zhu, Z. B., Lu, B., Park, M., Makhija, S. K., Numnum, T. M., Kendrick, J. E., Wang, M., Tsuruta, Y., Fisher, P., Alvarez, R. D., Zhou, F., Siegel, G. P., Wu, H., and Curiel, D. T.  Development of an optimized conditionally replicative adenoviral agent for ovarian cancer. Int J Oncol. 2008 Jun;32(6):1179-88. PMID:18497979

Ding, Q., Gladson, C. L., Wu, H. and Olman, M. A. Myofibroblast differentiation is negatively regulated by FAK-related non-kinase. J Biol Chem. 2008 Oct 3;283(40):26839-49. doi: 10.1074/jbc.M803645200. Epub 2008 Jul 31. PMID:18669633

Wu, H. and Curiel, D. T. Fiber-modified Adenoviruses for Targeted Gene Therapy. Methods Mol Biol. 2008;434:113-32. doi: 10.1007/978-1-60327-248-3_8. PMID:18470642

Matthews, Q. L., Yang, P., Wu, Q., Belousova, N., Rivera, A. A., Stoff-Khalili, M. A., Waehler, R., Hsu, H-C., Li, Z., Mountz, J., Wu, H. and Curiel, D. T. Optimization of capsid-incorporated antigens for an improved adenovirus vaccine approach. Virol J. 2008 Aug 21;5:98. doi: 10.1186/1743-422X-5-98. PMID:18718011

Ding Q., Gladson, C. L., Wu, H., Hayasaka, H., and Olman, M. A. FAK-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner. J Biol Chem. 2008 Oct 3;283(40):26839-49. doi: 10.1074/jbc.M803645200. Epub 2008 Jul 31. PMID:18669633

Icyuz, M., Bryant, S. M. J., Fortinberry, H. K., Molakandov, K., Siegal, G. P., Contreras, J. L., and Wu, H. Adenovirus infection activates Akt1 and induces cell proliferation in pancreatic islets. Transplantation. 2009 Mar 27;87(6):821-4. doi: 10.1097/TP.0b013e318199c686. PMID:19300183

Tang, Y., Wu, H., Ugai, H., Matthews, Q. L., and Curiel, D. T.  Derivation of a Triple Mosaic Adenovirus for Cancer Gene Therapy. PLoS One. 2009 Dec 31;4(12):e8526. doi: 10.1371/journal.pone.0008526. PMID:20046872

Matthews, Q. L., Fatima, A., Tang, Y., Perry, B. A., Tsuruta, Y., Komarova, S., Timares, L., Zhao, C., Makarova, N., Borovjagin, A. V., Stewart, P. L., Wu, H., Blackwell, J., and Curiel, D. T.  HIV Antigen Incorporation within Adenovirus Hexon Hypervariable 2 for a Novel HIV Vaccine Approach. PLoS One. 2010 Jul 27;5(7):e11815. doi: 10.1371/journal.pone.0011815. PMID:20676400

Nash, J. E., Appleby, V. J., Correa, S. A. L., Wu, H., Fitzjohn, S. M., Garner, C. C., Collingridge, G. L., and Molnar, E.  Disruption of the Interaction between Myosin VI and SAP97 is Associated with a Reduction in the Number of AMPARs at Hippocampal Synapses. J Neurochem. 2010 Feb;112(3):677-90. doi: 10.1111/j.1471-4159.2009.06480.x. Epub 2009 Nov 6.  PMID:19895665

Short, J. J., Rivera, A. A., Wu, H., Walter, M. R., Yamamoto, M., Curiel, D. T.  Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism and improves anti-tumor efficacy. Mol Cancer Ther. 2010 Sep;9(9):2536-44. doi: 10.1158/1535-7163.MCT-10-0332. Epub 2010 Aug 24. PMID:20736345

Borovjagin, A. V., Passineau, M. J., Dong, J., Ren, C., Lamani, E., Mamaeva, O. A., Wu, H., Keyser, E., Chen, S., MacDougall, M. J.  Adenovirus Gene Transfer to Amelogenesis Imperfecta Ameloblast-like Cells. PLoS One. 2011;6(10):e24281. doi: 10.1371/journal.pone.0024281. Epub 2011 Oct 7. PMID:22003382

Zhang, Yanqing, Zhang, Yuan, Bone, R. N., Cui, W., Peng, J-B., Siegal, G. P., and Wu, H. Regeneration of pancreatic non-β endocrine cells in adult mice following a single diabetes-inducing dose of streptozotocin. PLoS One. 2012;7(5):e36675. doi: 10.1371/journal.pone.0036675. Epub 2012 May 7. PMID:22586489

Wu, G., Zhang, W., Na, T., Jing, H., Wu, H., and Peng, J-B. Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe Syndrome and Dent Disease. Am J Physiol Cell Physiol. 2012 May 15;302(10):C1479-91. doi: 10.1152/ajpcell.00277.2011. Epub 2012 Feb 29. PMID:22378746

Wang, H., Wu, H., Rocuts, F., Gu, Z., Bach, F. H., Otterbein, L. E. Activation of peroxisome proliferator-activated receptor y prolongs islet allograft survival. Cell Transplant. 2012;21(10):2111-8. doi: 10.3727/096368911X637399. Epub 2012 Mar 28. PMID:22469179

Bone, R. N., Zhang, Y., Icyuz, Wang, H., M., Bryant, S. M. J., Siegal, G. P., Wu, H. Gene delivery of constitutively active Akt1 with an infectivity-enhanced adenoviral vector promotes islet cell survival and proliferation. In preparation.

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