Subramanyam N. Murthy, PhD
Research Associate Professor of Medicine
Adjunct Associate Professor of Pharmacology
Dr. Murthy’s research interests involve work on insulin resistance and diabetes and cardiovascular diseases in animal models with special emphasis on vascular responses to injury, pulmonary hypertension, endothelial and erectile dysfunction. In addition, nutritional components, particularly amino acids and the effects of various pharmaceutical preparations, are investigated in the context of vascular responses to injury and pulmonary hypertension. A major component of his ongoing work includes studies on intermediary metabolism, oxidative stress, stem cell therapy (native and gene modified), and an understanding of the molecular mechanisms involved in these processes.
Alt EU, Senst C, Murthy SN, Slakey DP, Dupin CL, Chaffin AE, Kadowitz PJ, Izadpanah R. Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res. 2012 Mar;8(2):215-25. Epub 2011 Nov 15.
Pankey EA, Badejo AM, Casey DB, Lasker GF, Riehl RA, Murthy SN, Nossaman BD, Kadowitz PJ. Effect of chronic sodium nitrite therapy on monocrotaline-induced pulmonary hypertension. Nitric Oxide. 2012 Mar 14. [Epub ahead of print].
Casey DB, Pankey EA, Badejo AM, Bueno FR, Bhartiya M, Murthy SN, Uppu RM, Nossaman BD, Kadowitz PJ. Peroxynitrite has potent pulmonary vasodilator activity in the rat. Can J Physiol Pharmacol. 2012 Apr;90(4):485-500. Epub 2012 Mar 27.
Nossaman BD, Pankey EA, Badejo AR, Casey DB, Uppu S, Murthy SN, Kadowitz PJ. Analysis of Responses to Glyceryl Trinitrate and Sodium Nitrite in the Intact Chest Rat. Nitric Oxide. 2012 Mar 28. [Epub ahead of print].
Murthy SN, Desouza CV, Bost NW, St Hilaire RC, Casey DB, Badejo AM, Dhaliwal JS, McGee J, McNamara DB, Kadowitz PJ, Fonseca VA. Effects of salsalate therapy on recovery from vascular injury in female Zucker fatty rats. Diabetes. 2010; 59(12):3240-6. Epub 2010 Sep 28.
Murthy SN, St Hilaire RC, Casey DB, Badejo AM Jr., McGee J, McNamara DB, Kadowitz PJ and Fonseca VA. The synthetic analog of GLP-1, exenatide reduces intimal hyperplasia in insulin resistant rats. Diabetes and Vascular Disease Research, 2010; 7(2):138-44. Epub 2010 Mar 2.
Lasker GF, Badejo AM Jr., Casey DB, Dhaliwal JS, Matt CJ, Murthy SN, Kadowitz PJ. Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy. Can J Physiol Pharmacol. 2010; 88(7):770-6.
Freisinger E, Cramer C, Xia X, Murthy SN, Slakey D, Chiu E, Newsome E, Alt E, Izadpanah R. Hematopoietic Potential of Adult Mesenchymal Stem Cells. J Cellular Physiology. 2010; 225(3):888-97. 2010 Jul 15. [Epub ahead of print].
Badejo AM Jr, Hodnette C, Dhaliwal JS, Casey DB, Pankey EA, Murthy SN, Nossaman BD Hyman AL, and Kadowitz PJ. Mitochondrial Aldehyde Dehydrogenase Mediates Vasodilator Responses of Glyceryl Trinitrate and Sodium Nitrite in the Pulmonary Vascular Bed of the Rat. Am J Physiol Heart Circ Physiol. 2010; 299(3):H819-26. Epub 2010 Jun 11.
Badejo, AM Jr., Nossaman VE, Pankey EA, Bhartiya M, Kannadka CB, Murthy SN, Nossaman BD, and Kadowitz PJ. Pulmonary and Systemic Vasodilator Responses to the Guanylyl Cyclase Stimulator, Bay 41-8543, are attenuated by L-NAME. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1153-9. Epub 2010 Jul 16.
St. Hilaire RC, Murthy SN, Kadowitz PJ, Jeter, Jr. JR. Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation. Peptides 2010; 31(8):1517-1522. Epub 2010 May 7.
Murthy SN, Nossaman, BD, and Kadowitz PJ. New approaches to the treatment of pulmonary hypertension: from bench to bedside. Cardiol Rev. 2010 March/April; 18(2): 76-84.
Murthy, SN, Sukhanov S, McGee J, Greco JA, Chandra S, Delafontaine P, Kadowitz PJ, McNamara DB, Fonseca VA. Insulin Glargine reduces carotid intimal hyperplasia after balloon catheter injury in Zucker fatty rats possibly by IGF-1 mediated reduction in oxidative stress. Mol Cell Biochem. 2009; 330(1-2):1-8. Epub 2009 Apr 10.
Murthy SN, Obregon DF, Chattergoon NN, Fonseca NA, Mondal D, Dunne BJ, Diez J, Jeter Jr JR, Kadowitz PJ, Agrawal KC, McNamara DB, and Fonseca VA. Rosiglitazone reduces serum homocysteine levels, smooth muscle proliferation and initmal hyperplasia in Sprague Dawley rats fed a high methionine diet. Metabolism (2005) 54 (5): 645-652.
Desouza CV, Murthy SN, Diez J, Dunne BJ, Matta AS, Fonseca VA, McNamara DB. Differential effects of peroxisome proliferator activator receptor a and g ligands on intimal hyperplasia after balloon catheter induced vascular injury in Zucker rats. J. Cardiovasc. Pharmacol. Therapeut. (2003) 8(4): 297-306.
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