Tulane Eosinophilic Disorder Center
Tulane Center for Eosinophilia Disorders under the leadership of Dr. Anil Mishra, PhD, is a first center of its kind in the southern region of the USA. The center will provide an opportunity for researchers, patients and their families to understand the disease and consult for better treatment of eosinophil associated disorders. The center will also provide an opportunity for basic research scientists to directly translate their experimental findings of the human disease with the help of clinicians. The center will be involved in basic, clinical and translational studies to determine the mechanistic aspects of eosinophilic disorders in the lung, skin and multiple gastrointestinal segments. The center’s aim is to develop diagnostic and therapeutic interventions for eosinophil associated multiple diseases.
Eosinophilic disorders occur when eosinophils, white blood cells with a bilobed nucleus with multiple toxic granules, are found in above-normal amounts in various parts of the body. In a healthy state eosinophils reside in the gastrointestinal tract; however, during allergic (food or aeroallergen) responses, a large number of eosinophils are generated from their precursors in response to the stimulus and move into the sites (responsive organ of the body) and release a variety of toxins that can cause chronic inflammation, resulting in tissue damage and repair.
Eosinophils have a critical role in promoting asthma, dermatitis, multiple gastrointestinal disorders and tissue remodeling (fibrosis).
We and other investigators found that eosinophils have a major role in promoting asthma, dermatitis and a number of gastrointestinal symptoms. Because of our growing knowledge and better diagnostic technology, we now have a better understanding of a number of allergic diseases. We are currently studying multiple compounds that might block eosinophil production and their recruitment into the tissues. Our research work indicated that in future we could provide the best treatment for eosinophil-associated multiple medical disorders such as asthma, eosinophilic dermatitis, eosinophil associated gastrointestinal disorders and tissue remodeling (fibrosis).
Basic and Clinical Studies at Our Center
Dr. Mishra’s general research is aimed at deciphering mechanisms of inflammation, primarily based on discoveries concerning innate immunity. In particular, gene-environment interactions in the elicitation of inflammatory states in the respiratory and gastrointestinal tracts are under investigation. Environmental triggers (such as aeroallergens and food allergens) are studied in the context of specific genetic variants (e.g. IL-15 and IL-18 signaling) using population studies (cross sectional and longitudinal prospective cohorts) and mechanism-driven studies. The biological properties of innate inflammatory cells (eosinophil, mast cells, NKT cells, epithelial cells) and the cytokines (especially chemokines) that mediate their function are under investigation. The contribution of these basic processes to diverse human inflammatory conditions (e.g. asthma, eosinophil associated gastrointestinal disorders) is pursued by translational studies often involving unique clinical resources (e.g. patient samples and databanks) and clinical intervention studies (e.g. anti-cytokine therapeutics).
Anil Mishra, PhD,
Endowed Schlieder Chair and Professor of Medicine, Pulmonary Diseases, Director, Tulane Eosinophilic Disorder Center, Tulane Medical Center, New Orleans, LA 70112
Focus area of our research
Eosinophilic Gastrointestinal Disorders:
Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include:
Our Tulane Collaborators
Future Clinical Trials
Patients and Family
Patients and families are encouraged to contact our center for any information needed to understand disease pathogenesis or treatment procedure for eosinophil related disorders.
Tulane Eosinophilic Disorder Center
Principal Investigator: Anil Mishra, PhD
Clinical Coordinator: Christine Glynn, RN
Funds needed for diagnostic and therapeutic interventions
Currently, we have very limited support from NIH and our research is very limited. We are in a need of funds to support our research program to find a permanent cure for eosinophil related lung skin and gastrointestinal disorders. We appeal to the general public and private funding agencies to provide the donations for our research programs.
Our research highlights:
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