- Molecular and Cellular Biology
- Oxygen-sensing Genetic Mechanisms
- Post-transcriptional Control of Oxygen Regulated Genes
- RNA Binding Proteins
- Angiogenesis and Cancer Research
Tumors require the formation of new blood vessels termed, angiogenesis, to grow. Targeting angiogenesis provides a novel approach for cancer therapy that rivals conventional therapy since drug resistance and tissue toxicity issues are avoided. Tumor angiogenesis depends on a balance between tumor-dependent angiogenic factors like VEGF (vascular endothelial growth factor) and host anti-angiogenic peptides like endostatin and angiostatin. The ability to alter this balance by favoring the anti-angiogenic effect by treatment with exogenous endostatin and angiostatin has been successfully demonstrated. However, a major difficulty in translating these strategies to the clinic is the lack of large quantities of these peptides for long-term treatment. An alternative strategy to disturb this balance is to disrupt VEGF or other angiogenic factor production.
Aline Betancourt, Ph.D.
Department of Microbiology & Immunology
Tulane University Health Sciences Center
1430 Tulane Ave., SL-38
New Orleans, LA, 70112
Tulane University, New Orleans, LA 504-865-4000 firstname.lastname@example.org