Ramesh S. Ayyala


Dr. Ramesh Ayyala is professor of ophthalmology, director of the Glaucoma Service, and director of the Residency Program as well as the Glaucoma/Anterior Segment Fellowship Program.

Dr. Ayyala attended medical school in Gandhi Medical College, Hyderabad, India on a National Merit Scholarship awarded by the government. While in medical school, he participated in numerous charitable eye camps in the southern Indian state of Andhra Pradesh.

He continued his training in ophthalmology in the United Kingdom, passing the prestigious FRCS examinations of the Royal College of Surgeons. He also was named a Fellow of the Royal College of Ophthalmologists. He went on to complete a residency at the University of South Florida, a glaucoma fellowship at the Massachusetts Eye and Ear Infirmary in Boston, and a fellowship in corneal and external diseases at the Boston Medical Center. While training in Boston, he was actively involved with the free eye clinic run by the Massachusetts branch of the Prevent Blindness Society.

Dr. Ayyala has been active in research and has published in the major ophthalmology journals. His current research interests include glaucoma drainage devices and the development of novel drug delivery systems to improve treatment of glaucoma. His innovative ideas have resulted in the creation of the "World's first slow release drug coated glaucoma drainage device" that is currently undergoing animal studies. Study-related developments and discussions are posted on -- a web-based teaching tool.

Select Peer-Reviewed Publications

  1. Rao PG, Scott JA, King A, Blyth C, Ayyala RS, Neoh C, Kaye SB. Comparison of patching versus no patching in the treatment of corneal abrasion (letter). Eye 1994; 8:371-372.

  2. Ayyala RS, O'Brien C, Grierson I, Maltby P. Transscleral flow of aqueous humor: An in vitro experiment. Ophthalmic Surg Lasers 1996; 27:66-69.

  3. Ayyala RS, Bellows AR, Thomas JV, Hutchinson BT. Bleb infections: Clinically different courses of "blebitis" and endophthalmitis. Ophthalmic Surg Lasers 1997; 28:452-460.

  4. Ayyala RS, Urban RC, Krishnamurthy MS, Mendelblatt D. Corneal blood staining following autologous blood injection for hypotony maculopathy. Ophthalmic Surg Lasers 1997;28: 866-868.

  5. Ayyala RS, Stevens SX, Grizzard SW, Fouraker BD. Recurrent endophthalmitis following cataract surgery with a scleral tunnel incision. Cornea 1998;17:233-235.

  6. Ayyala RS, Armstrong S. Corneal melting and scleromalacia perforans in a patient with pyoderma gangrenosum and acute myeloid leukemia. Ophthalmic Surg Lasers 1998;29:328-331.

  7. Ayyala RS, Pieroth L, Vinals AF, Goldstein MH, Schuman JS, Netland PA, Dreyer EB, Cooper ML, Mattox C, Frangie JP, Wu HK, Zurakowski D. Comparison of mitomycin-C trabeculectomy, glaucoma drainage devices and laser Nd: YAG cyclophotocoagulation in the management of intractable glaucoma following keratoplasty. Ophthalmology 1998;105:1550-1556.

  8. Ayyala RS, Zurakowski D, Smith J, Monshizadeh R, Netland PA, Richards DW, Layden WE. A clinical study of the Ahmed glaucoma valve implant. Ophthalmology 1998; 105:1968-1976.

  9. Ayyala RS, Cruz D, Harman L, Margo C, Mines J, Richards DW. Cystoid macular edema associated with latanoprost in pseudophakic and aphakic eyes. Am J Ophthalmol 1998; 126:602-604.

  10. Ayyala RS, Harman LE, Stevens SX, Margo CE, Michelini-Norris MB, Ondrovic LE. Comparison of different biomaterials for the glaucoma drainage devices. Arch Ophthalmol 1999; 117:233-236.

  11. Ayyala RS. Cyclophotocoagulation for glaucoma after penetrating keratoplasty (letter). Ophthalmology 1999; 106:645.

  12. Ayyala RS, Margo CE, Michelini-Norris MB. Comparison of different biomaterials for the glaucoma drainage devices: Part 2. Arch Ophthalmol 2000; 118:1081-1084.

  13. Ayyala RS. Penetrating keratoplasty and glaucoma. Surv Ophthalmol 2000; 45:91-105.

  14. Ayyala RS, Layden WE, Slonim CB, Margo CE. Anatomic and histopathologic findings following a failed Ahmed glaucoma valve device. Ophthalmic Surg Lasers 2001; 32:248-249.

  15. Ayyala RS, Tran C, Bellows AR, Hutchinson BT. Open angle glaucoma secondary to blood clot in the Schlemm's canal following acute episcleral venous compression and its treatment with tPA. Ophthalmic Surg Lasers 2001; 32:145-148.

  16. Ayyala RS, Zurakowski D, Hong C, Monshizadeh R, Richards DW, Layden WE, Hutchinson BT, Bellows AR. Advanced uncontrolled glaucoma: Double-plate Molteno vs Ahmed glaucoma valve. Ophthalmic Surg Lasers 2002; 33:94-101.

  17. Hong CH, Arosemena A, Zurakowski D, Ayyala RS. Glaucoma drainage devices: A systematic literature review and current controversies. Surv Ophthalmol 2005;48-60.

  18. Callahan C, Ayyala RS. Topical timolol/dorzolamide-induced hypotony and choroidal effusion in patients with previous glaucoma drainage device implantation. Ophthalmic Surg Lasers Imaging 2003; 34:467-469.

  19. Ayyala RS, Parma SE, Karcioglu ZA. Optic nerve changes following posterior insertion of glaucoma drainage device in a rabbit model. J Glaucoma 2004;13:145-148.

  20. Stewart RM, Diamond JG, Ashmore ED, Ayyala RS. Complications following Ex-Press® glaucoma shunt implantation. Am J Ophthalmol 2005;140:340-341.

  21. Stewart RM, Diamond JG, Ashmore ED, Ayyala RS. Complications following Ex-Press® glaucoma shunt implantation: Supplemental Material. AJO COM 2005; 140:340-341.

  22. Minckler D, Ayyala R, Francis B, Mathew MC. Aqueous shunts for glaucoma. (Protocol for a Cochrane Review) In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley and Sons, Ltd.

  23. Ayyala RS: Modified Ahmed valve drainage into the sinuses (letter). Surv Ophthalmol 2005.

  24. Blake DA, Clinton AD, Galler KE, Johnson PY, Sahiner N, Ross ND, John VT, Walsh M, Ayyala RS. Inhibition of cell proliferation by mitomycin C incorporated into P(HEMA) hydrogels: Mitomycin C in a P(HEMA) matrix - A novel slow release drug delivery system to decrease encapsulation/fibrosis following glaucoma drainage device implantation: An in-vitro test of efficacy. J Glaucoma 2006;15:291-298.

  25. Minckler DS, Vedula SS, Li TJ, Mathew MC, Ayyala RS, Francis BA. Aqueous shunts for glaucoma. Cochrane Database Syst Rev 2006 Apr 19;(2):CD004918. Review.

  26. Ayyala RS, Durate J L, Sahiner N. Glaucoma drainage devices: State of the art. Expert Rev Med Devices 2006;3:509-521.

  27. Dodson D, Stewart R, Karcioglu Z, Conway MD, Mushatt D, Ayyala RS. Klebsiella pneumoniae endophthalmitis secondary to liver abscess presenting as acute iridocyclitis. Ophthalmic Surgery Lasers Imaging (In press).

  28. DellaCroce J, Laursen J, Ayyala RS. Serous retinal detachment following glaucoma surgery. Ophthalmic Surg Lasers Imaging 2007; 38(6):503-4.

  29. Hinkle DM , Zurakowski D, Ayyala RS. A comparison of the polypropylene plate AhmedTM glaucoma valve to the silicone plate AhmedTM glaucoma flexible valve Eur J Ophthalmol 2007;17(5)696-701.

  30. Lin YP, Zurakowski D, Ayyala RS. Traditional limbal-based trabeculectomy versus fornix-based trabeculectomy with corneal valve: Surgical outcomes. Ophthalmic Surg Lasers Imaging 2007;38(6):471-7.

  31. Ayyala RS. Lessons from Katrina: A program director's perspective. Ophthalmology2007; 114(8):1425-6.

  32. Ayyala RS. A new resident educational tool. J Academic Ophthalmology 2008;1:86-89.

  33. Sahiner N, Kravitz DJ, Qadir R,Blake DA, Haque S, John VT, Margo C,Ayyala RS. Creation of A Drug- Coated Glaucoma Drainage Device Using Polymer technology: In Vitro and In Vivo Studies. Archives of Ophthalmology (in press).

  34. F. A. Irshad, R. S. Ayyala, M.S. Mayfield, D. Zurakowski. Variation in Schlemm Canal Size and Location by Ultrasound Biomicroscopy. Ophthalmology (under revision).


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