Eosinophils account for up to 6% of blood leukocytes. They are about the same size as neutrophils. Most have 2 connected nuclear segments (occasionally 3) with condensed chromatin. Distinctive, large refractile orange granules are their key feature for identification. Eosinophils can increase in allergic and drug reactions, severe stress such as burns or surgery, severe infection, and parasitic infestation. High numbers of eosinophils releasing their toxic cytokines can result in much collateral tissue damage. Infrequently, they are phagocytic.
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