Parvovirus B19 causes one of the childhood exanthams "erythema infantosum," also known as "fifth disease" or "slapped cheek disease." It also may cause a transient aplastic anemia by infecting and destroying early erythroid progenitor cells. Most people recover with little to no symptoms beyond "a cold," but people with a chronic hemolytic anemia (which shortens the lifespan of the circulating RBCs) may experience a severe aplastic crisis. Hydrops fetalis and fetal death have also been seen with parvovirus infection. The image shows an enlarged, infected, early erythroid progenitor cell. the central clearing in the nucleus represents the viral inclusion.
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