Mantle cell lymphoma is a neoplasm of the small B-cells which form the mantle layer of the follicle. The neoplastic mantle cells form expanded mantle layers that eventually overrun the germinal centers, forming nodules that may coalesce info a diffuse pattern. At low power, a vaguely nodular pattern may be seen. At high power the cells are small with a round nuclear contour and a small amount of cytoplasm. This B-cell lymphoma is of intermediate aggressiveness and requires prompt treatment.
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