Hematopathology — Image #39 — Malt Lymphoma

MALTOMA: Extranodal Marginal Zone B-cell Lymphoma

Low Power Image, Gastic Mucosa Invaded:

Low Power Image, Gastic Mucosa Invaded

The image shows a gastric MALToma (Mucosal Associated Lymphoid Tissue lymphoma). This is a low-grade neoplasm in which the neoplastic monocytoid B-cells invade the stroma and the glands. (In normal lymph nodes, the monocytoid cells are found at the far perimeter of the mantle zone, cortex, and around sinusoids. The normal and neoplastic cells are thought to have particular tissue homing patterns.) The neoplastic cells are accompanied by foci of plasma cells (neoplastic derivatives of clone in 40% of cases) and reactive, non-neoplastic germinal centers. Maltomas arise in the context of chronic inflammation, notably with H. Pylori gastric infection, Hashimoto's thyroiditis, and Sjogren's syndrome in salivary and lacrimal glands.

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