Hematopathology — Image #40 — Diffuse Large B-Cell Lymphoma

Low Power:

Diffuse Large B-Cell Lymphoma, Low Power

High Power:

Diffuse Large B-Cell Lymphoma, High Power

At low power you can see how the normal architecture of the lymph node has been completely effaced by the lymphoma. Close-up, the neoplastic lymphocytes are large, with a large irregular nucleus and coarse chromatin. Mitotic figures are easily found. This lymphoma may occur de novo, or as an advanced phase of a pre-existing B-cell lymphoma such as follicular or monocytoid types. These are aggressive lymphomas requiring prompt treatment.


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