Carcinoma Metastatic to Bone Marrow
Low Power H&E of Metastatic Carcinoma to Bone Marrow:
Cytokeratin Stain of Carcinoma Metastatic to Bone Marrow:
Many carcinomas can metastasize to bone marrow, notably breast, lung, thyroid, kidney, and prostate. Carcinoma cells may announce their presence in marrow by a desmoplastic reaction, or sneak in almost imperceptibly with scattered cells only slightly larger than the hematopoietic cells. Special stain for cytokeratin is helpful; here the metastatic cells are clearly highlighted. Bone marrow involvement counts as "distant mets" in staging and indicates a high stage tumor.
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