Dept. of Pharmacology, 8683
School of Medicine
Tulane University
1430 Tulane Ave
New Orleans, LA 70112

Learning Objectives

Our graduate curriculum, including lectures and exams, are  focused on specific learning objectives. Examples of learning objectives for some specific lectures are shown below. Each lecture handout contains the objectives that students should focus on to master the material being covered.


Representative Learning Objectives for Graduate lectures:


Cytochrome P-450 (Principles of Pharmacology Course)
Dr. George

By the end of this session, you should be able to:

  1. Describe the distribution of P-450 enzymes.
  2. Describe the isolation of microsomal and mitochondrial fractions.
  3. Explain the electron transport system in the microsomal drug metabolizing system.
  4. Discuss the differences between P-450 mediated oxidative and reducing reactions.
  5. List various types of major human P-450 isozymes and specific substrates.
  6. Explain P-450 enzyme induction and inhibition by drugs and their interaction.

By the end of this session, you should be able to:

Nitric Oxide:

  1. Explain the chemical properties of NO.
  2. Describe the role of NO in the regulation of smooth muscle, nervous system & inflammatory cell function.
  3. Explain the signal transduction mechanisms by which NO regulates cellular function.
  4. Explain the role of alterations in NO formation in disease states.

Arachidonic Acid:

  1. Explain the role of omega-3 and omega-6 series polyunsaturated fatty acids in the formation of lipid mediators.
  2. Describe the role of prostaglandins, cyclooxygenase (Cox-1, Cox-2) and lipoxygenase products in physiological regulation of organ function.
  3. Explain the role of prostaglandin & lipoxygenase products in pathophysiologic states (arthritis, asthma).
  4. Describe the mechanism by which Cox and lipoxygenase inhibitors and antagonists are useful in the treatment of arthritis & asthma.

By the end of this session, you should be able to:

  1. Describe the central role of ROS in normal metabolic functions, and in disease pathogenesis, e.g. inflammation, atherosclerosis, cancer, AIDS, aging, etc...
  2. List the major classes of ROS, their sources, and properties.
  3. Explain the role of Mitochondrial electron transport chain (ETC) in ROS generation.
  4. Describe the Fenton and Haber-Weiss reactions which generate hydroxyl radicals.
  5. Explain the deleterious consequences of ROS on DNA, proteins, and lipids.
  6. Describe the major anti-oxidant defence systems and their mechanisms of action.


1430 Tulane Avenue, SL-83, New Orleans, LA 70112 504-988-5444