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Kailash N. Pandey, PhD
Professor and Vice Chair: Medical Research
Phone: (504) 988-1628
Room #: 4022

Email: kpandey@tulane.edu

Ph.D.: University of Kentucky, 1979


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Research Interest:

The primary goal of our research is to determine the genetic and molecular basis of hypertension and cardiovascular disorders. The long-term objectives of our research projects are to determine the molecular and cellular action of atrial natriuretic peptide (ANP) that controls blood pressure and cardiovascular homeostasis. Our research has focused on the regulatory action of ANP that is mediated by interacting with guanylyl cycles/ natriuretic peptide receptor-A (GC-A/NPRA) which synthesizes the intracellular second messenger cGMP and plays a central role in pathophysiology of hypertension and cardiovascular disorders. We hope to learn the structural components of the receptor that might be critical for the hormone-dependent signaling process in model system cell lines and the Npr1 (coding for GC-A/NPRA) gene-targeted mutant mice generated by homologous recombination that either disrupted (knockout) or duplicated the Npr1 gene. Our studies are also aimed to test directly the efficacy of NPRA regulatory elements, and the impact of Npr1 gene dosage and null mutation in the regulation of blood pressure and cardiovascular disorders.

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20170805_223251        Laboratory members:
  • Prerna Kumar, PhD – Instructor and Collaborator
  • Samivel Ramachandran, PhD- Postdoctoral Fellow
  • Hanqing, Zhao, PhD – Postdoctoral Fellow
  • Meaghan Bloodworth, BS – Lab. Research Technician
  • Krishna Pandya, BS – Medical Student
  • Helene Chen, BS – Medical Student
  • Christian Nguyen, BS – Undergraduate

 

 

     20170805_173436     Christopher pic2 Christopher pic6     20170805_173031

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Representative Publications:

  1. Vellaichamy V, Das S, Subramanian U, Maeda N, Pandey KN. Genetically altered mouse models of guanylyl cyclase/natriuretic peptide receptor-A exhibit cardiac expression of pro-inflammatory mediators in a gene-dose-dependent manner. Endocrinology, 155:1045-1056 (2014).
  2. Kumar P, Tripathi S, Pandey KN. Histone deacetylase inhibitors modulate the transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-A: Interactive roles of modified histones, histone acetyltransferase, p300, and SP-1. J. Biol. Chem. 289:6991-7002 (2014).
  3. Kumar P, Periyasamy R, Das S, Mani I, Pandey KN. All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor-A gene transcription: Role of histone modification. Mol. Pharmacol. 85:946:957 (2014).
  4. Mani I, Garg R, Tripathi S, Pandey KN. Subcellular trafficking of guanylyl cyclase/natriuretic peptide/receptor-A with concurrent generation of intracellular cGMP. Bioscience Report, 35(article: e0026): 1-17 (2015).
  5. Mani I, Garg R, Pandey KN. Role of FQQI motifs in the internalization, trafficking and signaling of guanyly cyclase/natriuretic peptide receptor-A in cultured mouse messangial cells. Am. J. Physio.-Renal Physio., 310:F68-84 (2016).
  6. Sen A, Kumar P, Garg R, Lindsey SH, Katakam PVG, Bloodworth M, Pandey KN. Transforming growth factor-β1 antagonizes the transcription, expression, and vascular signaling of guanylyl cyclase/natriuretic peptide receptor-A gene by TGF-β1: Role of δ EF-1. FEBS J., 283: 1767-1781 (2016).

Recent Publications: A PubMed listing of research publications for Kailash N. Pandey, Ph.D.

1430 Tulane Ave, New Orleans, LA 70112 504-988-5251 physiology@wave.tulane.edu