Prerna Kumar, PhD
Phone: (504) 988-6599
Room #: 4168/4018
PhD: Jawaharlal Nehru University, School of Biotechnology,
New Delhi, India, 2004
My major research interest is to understand the molecular mechanisms governing the regulation of natriuretic peptide (NP) receptor expression. Natriuretic peptides and their receptors have physiological and pathophysiological importance including cardiovascular, renal, and immunological aspect in normal and disease conditions. Atrial natriuretic peptide (ANP) and brain NP (BNP) binds to NP receptor-A (NPRA), C-type NP (CNP) binds to NP receptor-B (NPRB), and all three NP binds to NP receptor-C (NPRC) which mediates their biological functions. The focus of my research is to elucidate interactive roles of DNA binding proteins involved in regulation of natriuretic peptide receptors. Ongoing studies involve identification of epigenetic signaling and role of transcription factors in regulating NP receptor expression and function by utilizing molecular biology techniques and cell culture system.
- Kumar P, Garg R, Bolden G, Pandey KN. Interactive roles of Ets-1, Sp1, and acetylated histones in the retinoic acid-dependent activation of guanylyl cyclase/atrial natriuretic peptide receptor-A gene transcription. J Biol Chem. 2010 Nov 26;285(48):37521-30.
- Kumar P, Pandey KN. Cooperative activation of Npr1 gene transcription and expression by interaction of Ets-1 and p300. Hypertension. 2009 Jul;54(1):172-8. Epub 2009 Jun 1.
- Kumar P, Bolden G, Arise KK, Krazit ST, Pandey KN. Regulation of natriuretic peptide receptor-A gene expression and stimulation of its guanylate cyclase activity by transcription factor Ets-1. Biosci Rep. 2009 Feb;29(1):57-70.
- Kumar P, Arise KK, Pandey KN. Transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-A gene. Peptides. 2006 Jul;27(7):1762-9.
Recent Publications: A PubMed listing of research publications for Prerna Kumar, Ph.D.