Yan Dong, Ph.D.
Our primary research interests have focused on the development of effective approaches to prevent prostate cancer or to overcome resistance to hormone therapy and chemotherapy for prostate and breast cancer. We are also interested in developing novel preclinical models for studying hormone therapy for breast cancer in postmenopausal women.
Liu S, Qi Y, Ge Y, Duplessis T, Rowan BG, Ip C, Cheng H, Rennie PS, Horikawa I, Lustig AJ, Yu Q, Zhang H, and Dong Y. Telomerase as an important target of androgen-signaling blockade for prostate cancer treatment. Molecular Cancer Therapeutics, 9:2016, 2010.
Zhang H, Yao D, Wu Y, Ip C, and Dong Y. Activation of FOXO1 Is Critical for the Anticancer Effect of Selenium in Prostate Cancer Cells. Prostate, 70:1265, 2010.
Liu S, Zhang H, Zhu L, Zhao L, Dong Y. KLF4 is a novel mediator of selenium in growth inhibition. Molecular Cancer Research, 6:1, 2008.
Li S, Zhou Y, Wang R, Zhang H, Dong Y, Ip C. Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-akt and its downstream substrates. Molecular Cancer Therapeutics, 6:1031, 2007.
Zhang H, Wu Y, Malewicz B, Lu J, Li S, Marshall JR, Ip C, Dong Y. Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid. Cancer, 107:2942, 2006.
Dong Y, Zhang H, Gao AC, Marshall JR, Ip C. Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Molecular Cancer Therapeutics, 4:1047, 2005.
Dong Y, Lee S, Zhang H, Marshall JR, Gao AC, Ip C. Prostate specific antigen (PSA) expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res, 64:19, 2004.
Dong Y, Zhang H, Hawthorn L, Ganther HE, Ip C. Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Research, 52:708, 2003.
Dong Y, Ganther HE, Stewart C, Ip C. Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays. Cancer Research, 62:708, 2002.