1. Inflammation and cancer, molecular and cellular biology of cancer. The focus is on IL-17, macrophages, and prostate and lung cancer. 2. Developmental biology of articular joint, tissue engineering and regeneration of articular cartilage using stem cells. The focus is on doublecortin (DCX), a gene originally identified from neurons by other investigators. Dr. You's group first discovered that this gene is also expressed in articular chondrocytes and their progenitor cells.
Dr. You received his M.D. and Ph.D. from the West China University of Medical Sciences in 1989 and 1994, respectively. From 1994 to 1998, Dr. You was a postdoctoral fellow and then a gynecologic oncologist at the Beijing Medical University First Hospital. In 1998, Dr. You joined the University of Freiburg, Freiburg, Germany, as a research scientist to investigate adenovirus-mediated cancer gene therapy. In 2000, he moved to the University of Michigan, Ann Arbor, as a research fellow focusing on molecular signaling and apoptosis in cancer. In 2003, Dr. You joined the faculty of the University of California Davis as an adjunct instructor and then an adjunct assistant professor in the Department of Orthopaedic Surgery, working on IL-17RC in prostate cancer and DCX in articular cartilage. In 2008, Dr. You joined the faculty of the Tulane University Health Sciences Center as an assistant professor in the Department of Structural and Cellular Biology and an adjunct assistant professor in the department of orthopaedic surgery. Dr. You is also a member of Tulane Cancer Center and Tulane Center for Aging.