W T. GodbeyW T. Godbey
Associate Professor

Phone: (504) 865-5872

301 Lindy Boggs Building
Department of Chemical & Biomolecular Engineering
Tulane University
New Orleans, LA 70118-5674

Research Interests

Gene delivery, Cellular engineering, Molecular aspects of nonviral transfection, Biomaterials

The research projects of this laboratory are encompassed by the development and application of gene therapy techniques for tissue and cellular engineering. The design and testing of novel gene delivery vehicles is of some interest, while the application of gene therapy for clinically oriented results is a major focus of the laboratory.

One major project in the Godbey laboratory is focused on the treatment of an entire class of cancers via expression-targeted gene delivery. The delivered DNA in this application acts as a "smart gene" to selectively cause the destruction of specific cancer cells while having little or no effect upon healthy, untransformed cells. This method is showing great promise as a possible treatment for many conditions such as bladder, colon, and prostate cancers.

Other projects include the merging of the fields of molecular and cell biology with engineering to yield cells that are receptive to artificial external signals. Following the administration of an external, user-controlled signal, the engineered cells are to respond in a predetermined way that might include the production of specific factors or an altered behavior such as enhanced mobility. Such engineered cells are excellent candidates for seeding onto biodegradable scaffolds. Over time, these scaffolds would mature into implants suitable for eventual implantation into waiting patients.

300 Lindy Boggs Center, Tulane University, New Orleans, LA 70118, T: 504-314-2914, F: 504-865-6744