331 Lindy Boggs Building
Department of Chemical & Biomolecular Engineering
New Orleans, LA 70118-5674
Self-Assembly and Nanostructured Materials, Polymer/nanoparticle composites, biomolecular materials, microemulsion systems, clathrate hydrate thermodynamics
I work in the highly interdisciplinary areas of lipid self-assembly, drug and vaccine delivery, and the development of nanostructured materials. The self-organization of amphiphilic molecules (such as biological lipids and synthetic surfactants) is essential in technologies as mundane as consumer detergent products, and techologies of the future as in the development of structured, responsive nanomaterials. Biological membranes are ubiquitous examples of lipid-self assembly that impacts the entire function of a cell. A major project that I am now working on, is in the exploitation of lipid self-assembly to induce transcutaneous vaccine delivery. Vaccine development and needle free vaccine delivery is a grand challenge problem being addressed by researchers at the Medical School and at the Uptown Campus at Tulane, and I am privileged to be part of this group.
Other exciting projects incollaboration with the Medical School involve the development of drug containing ultrathin polymer films as coatings for glaucoma drainage devices and for surgical implants, the development of novel tubular liposomes for drug delivery in osteosarcoma treatment, and for DNA vaccine delivery.
We have also started a major program in the development of dispersants to be used in oil spills. Of course, the impetus for the research comes from the tragedy in 2010 with the Deepwater Horizon incident in the Gulf of Mexico. I am part of a wonderful consortium (Consortium for the Molecular Engineering of Dispersants - CMEDS, http://dispersant.tulane.edu) of 43 investigators from 22 institutions. We are funded by the Gulf of Mexico Research Initiative (GOMRI - www.gulfresearchinitiative.org).
Among the most rewarding outreach activities I have participated in is the establishment of a collaboration with Nunez Community College on setting up new facilities for process technology operator training. The facilities have benefitted not only the process technology students at Nunez, but also Chemical Engineering students who are able to get a first hand training opportunity on mini plant scale systems.
At Tulane, we have developed a wonderful cryo-electron microscopy facility with both cryo-SEM and cryo-TEM. All my students are trained in cryo-microscopy. Many of my students also get to learn neutron scattering at the National Center for Neutron Research (NIST, Md). Tulane operates in a highly collaborative, highly interdisciplinary setting, allowing my students to gain tremendously from the resources of the entire university and the multiple collaborations that I seek to establish.
I work in the highly interdisciplinary areas of lipid self-assembly, drug and vaccine delivery, and the development of nanostructured materials. The self-organization of amphiphilic molecules (such as biological lipids and synthetic surfactants) is essential in technologies as mundane as consumer detergent products and those of the future as in the development of structured, responsive nanomaterials. Biological membranes are ubiquitous examples of lipid-self assembly that impact the entire function of a cell. A major project that I am now working on is in the exploitation of lipid self-assembly to induce transcutaneous vaccine delivery. Vaccine development and needle free vaccine delivery is a grand challenge problem being addressed by researchers at the Medical School and at the Uptown Campus at Tulane, and I am privileged to be part of this group. Funding for my research comes from the National Science Foundation, the National Institutes of Health and the Environmental Protection Agency.
An entirely separate problem I am working on is the development of technologies based on clathrate hydrates. These are inclusion compounds of gas and water where the water molecules form cage-like structures to encapsulate gas molecules. They have tremendous implications in natural gas recovery, processing and storage. Together with colleagues at Tulane, Hamilton College and Los Alamos National Laboratories, we are trying to exploit novel clathrate systems for use in hydrogen storage for next generation fuel-efficient vehicles. This research is funded by the Department of Energy.
Zhang, Y.; Xuan, S.; Owoseni, O.; Omarova, M.; Li, X.; Saito, M.; He, J.; McPherson, G.; Raghavan, S.; Zhang, D.; John, V. "Amphiphilic Polypeptoids Serve as the Connective Glue to Transform Liposomes into Multilamellar Structures with Closely Spaced Bilayers", Langmuir, (in press).
Abshire, C.; Murad, H.; Arora, J.; Liu, J.; Daigle, J.; Mandava, S.; John, V.; Khismatullin, D.; Lee, B. "Focused Ultrasound Triggered Release of Tyrosine Kinase Inhibitor from Thermosensitive Liposomes for Treatment of Renal Cell Carcinoma", J. Pharm. Sci. (in press).
Katepalli, H.; John, V.; Tripathi, A.; Bose, A. "Microstructure and Rheology of Particle Stabilized Emulsions: Effects of Particle Shape and Inter-Particle Interactions", J. Colloid and Interface Sci. 2017, 485(1), 11.
Arora, J.; Cremaldi, J.; Holleran, M.; Ponnusamy, T.; Sunkara, B.; He, J.; Pesika, N.; John, V. "Hierarchical Patterning of Hydrogels by Replica Molding of Impregnated Breath Figures leads to Superoleophobicity", Nanoscale, 2016, 8, 18446.
Arora, J.; Cremaldi, J.; Holleran, M.; Ponnusami, T.; He, J.; Pesika, N.; John, V. "Hydrogel Inverse Replicas of Breath Figures Exibit Superoleophobicity due to Patterned Surface Roughness", Langmuir, 2016, 32, 1009.
Arora, J.; Murad, H.; Ashe, S.; Halliburton, G.; Yue, H.; John, V.; Khismatullin, D. "Ablative Focused Ultrasound Synergistically Enhances Thermally Triggered Chemotherapy for Prostate Cancer in vivo", Molecular Pharmaceutics, 2016, 13 (3080).
John, V.; Arnosti, C.; Field, J.; Kujawinski, E.; McCormick, A. "The Role of Dispersants on Oil Spill Remediation", Oceanography, 2016, 29(3), 87.
Saha, A.; John, V.; Bose, A. "Facile Synthesis, Characterization and Catalytic Activity of Nanoporous Supports Loaded with Monometallic and Bimetallic Nanoparticles, Colloids and Surfaces A., 2016, 491, 57.
Xuan, S.; Lee, C.; Chen, C.; Doyle, A.; Zhang, Y.; Guo, L.; John, V.; Hayes, D.; Zhang, D. "Thermoreversible and Injectable ABC Polypeptoid Hydrogels: Controlling the Hydrogel Properties through Molecular Design", Chem. Mater., 2016, 28(3), 727.
Owoseni, O.; Nyankson, E.; Zhang, Y.; Adams, D.; He, J.; Spinu, L.; McPherson, G.; Bose, A.; Gupta, R.; John, V. "Interfacial Adsorption and Surfactant Release Characteristics of Magnetically Functionalized Halloysite Nanotubes for Responsive Emulsions", Journal of Colloid and Interface Sci. 2016, 463, 288.
Kalliola, S.; Repo, E.; Sillanpaa, M.; Arora, J.; He, J.; John, V. "The Stability of Green Nanooparticles in Increased pH and Salinity for Applications in Oil-Spill Treatment", Colloids and Surfaces A, 2016, 491, 57.
Cremaldi, J.; Ejaz, M.; Oak, S.; Holleran, M.; Roberts, K.; Cheng, G.; Wang, Y.; Grayson, S.; Pesika, N. "Polymer Grafted Hard Carbon Microspheres at an Oil/Water Interface", J. Colloid and Interface Sci., 2016, 470, 31.
Riehm, D.; Bothun, G.; John, V.; Raghavan, S.; McCormick, A. "Oil Dispersants Based on Food Grade Amphiphiles: Influence of Dispersant Composition, Dosage and Solvent on Dispersion Effectiveness", Marine Pollution Bulletin, 2015, 101(1), 92.
Owoseni, O.; Zhang, Y.; Su, Y.; He, J.; McPherson, G.; Bose, John V. "Tuning the Wettability of Halloysite Clay Nanotubes by Surface Carbonization for Optimal Emulsion Stabilization", Langmuir, 2015, 31(51), 13700.
Arora, J.; Ponnusamy, T.; Zheng, R.; Venkataraman, P.; Raghavan, S.; Blake, D.; John, V. "Spatially Directed Vesicle Capture in the Ordered Pores of Breath Figure Polymer Films", Soft Matter, 2015, 11, 5188.
Sunkara, B.; Su, Y.; Zhan, J.; He, J.; McPherson, G.; John, V. "Iron-Carbon Composite Microspheres Prepared through a Facile Aerosol Based Process for the Simultaneous Adsorption and Reduction of Chlorinated Hydrocarbons", Front. Environ. Sci. & Eng. 2015, 9(5), 939.
Saha, A.; John, V.; Bose, A. "In-situ Assembly of Hydrophilic and Hydrophobic Nanoparticles at Oil Water Interfaces as Versatile Strategy to form Stable Emulsions", ACS Applied Materials & Interfaces, 2015, 7(38), 21010..
Nyankson, E.; Owoseni, O.; John, V.; Gupta, R. "Surfactant-loaded Clay Nanotube Dispersants as an Oil Dispersant Additive", Industrial & Engineering Chemistry, 2015, 54(38), 9328.
Grabacka, M.; Waligorski, P.; Zapata, A.; Blake, D.; Wyczechowska, D.; Wilk, A.; Vashistha, H.; Ayyala, R.; Ponnusamy, T.; Culichhia, F.; Reiss, K. "Fenofibrate Subcellular and Tissue Distribution as a Rationale for he Intracranial Delivery through a Biodegradable Carrier",J. Physiol. Pharmacol., 2015, 104(3), 1187.
Gupta, D.; John, V.; Maldarelli, C.; John, G. "Sacrifical Amphiphiles: Eco-friendly Chemical Herders as Oil Spill Mitigation Chemicals", Science Advances, 1(5) e1400265.
Benner, S.; John, V.; Hall, C. "Simulation Study of Hydrophobically Modified Chitosan as an Oil Dispersant Additive", J. Phys. Chem. B., 2015, 119(23), 6979.
Schoenberg, E.; Blake, D.; Swann, F.; Parlin, A.; Zurakowski, D.; Margo, C.; Polnnusamy, T.; John, V.; Ayyala, R.; "Effect of Two Novel Sustained Release Drug Delivery Systems on Bleb Fibrosis: An in vivo Glaucoma Drainage Device Study in a Rabbit Model", Trans. Vis. Sci. Technol, 2015, 4(3): Article 4.
Liu, J.; Boonkaew, B.; Arora, J.; Mandava, S.; Maddox, M.; Callaghan, C.; Chava, C.; He, J.; Dash, S. John, V.; Lee, B. "Comparison of Sorafenib-loaded Poly(Lactic/Glycolic) Acid and DPPC Liposome Nanoparticles in the in-vitro Treatment of Renal Cell Carcinoma", J. Pharmaceutical Sci., 2015, 104(3), 1187.
Dhule, S.; Penformis, P.; He, J.; Harris, M.; Terry, T.; Pochampally, R.; John, V. "The Combined Effects of Encapsulating Curcumin and C6 Ceramide in Liposomal Nanoparticles against Osteosarcoma", Molecular Pharmaceutics, 2014, 11, 417.
Ponnusamy, T.; Mondal, D.; Chakravarty, G.; John, V. "Novel Breath Figure Based Synthetic Porous PLGA Matrices for In Vitro Modeling of Mammary Morphogenesis and Assessing Chemotherapeutic Response", Advanced Healthcare Materials, 2014, 3(5), 703.
Owoseni, O; Nykanson, E.; Zhang, Y.; Adams, S.; He, J.; McPherson, G.; Bose, A.; Gupta, R.; John, V. "Release of Surfactant Cargo from Interfacially-Active Halloysite Clay Nanotubes for Oil Spill Remediation", Langmuir, 2014, 30(45), 13533
Zheng, R.; Arora, J.; Boonkaew, B.; Raghavan, S.; Kaplan, D.; He, J.; Pesika, N.; John, V. "Liposomes tethered to a Biopolymer Film through the Hydrophobic Effect create a Highly Effective Lubricating Surface", Soft Matter, 2014, 10(46), 9226.
Venkataraman, P.; St. Dennis, J.; Zheng, R.; Arora, J.; Owoseni, O.; John, V.T.; Raghavan, S. "Self-Assembling Gels of a Hydrophobically Modified Biopolymer", Materials Research Society Symp. Ser., 2014, 1622.
Boonkaew, B.; Barber, P.; Supaphol, P.; Rengpipat, S.; Kempf, M.; Cuttle, L.; He, J.; John, V.T. "Novel Antimicrobial Hydrogel Dressing for Burn Wounds: A Single Step Production through Gamma Irradiation to serve SNPs and Radical Polymerization", J. Pharmaceutical Sci., 2014, 3(5), 703.
Ponnusamy, T.; John, V.; Ayyala, R.; Blake, D. "A Novel Antiproliferative Drug Coating for Glaucoma Drainage Devices", J. Glaucoma, 2014, 23(8), 526.
Athas, J.; Jun, K.; McCafferty, C.; Owoseni, O.; John, V.; Raghavan, S. "An Effective Dispersant for Oil Spills Based on Food-Grade Amphiphiles", Langmuir, 2014, 30(31), 9285.
Maddox, M.; Liu, J.; Mandava, S.; Callaghan, C.; John, V.; Lee, B. "Nanotechnology Applications in Urology: A Review", BJUI Intl., 2014, 114(5), 653.
Holder, G.E.; McGary, C.M.; Johnson, E.M.; Zheng, R.; John, V.; Sugimoto, C.; Kuroda, M.; Kim W-K. "Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: a Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection", J. Neuroimmune Pharm., 2014, 9, 716.
Zheng, R.; Zhan, J.; Kaplan, D.; Wang, X.; Pesika, N.; John, V. "Lubrication Properties of Phospholipid Liposome Coated Silk Microspheres", Particle & Particle Systems Characterization, 2013, 30, 133.
Ejaz, M.; Sunkara, B.; Kamboj, L.; He, J.; John, V.; Grayson, S. "Facile One-Pot Method of Initiator Fixation for Surface Initated Atom Radical Polymerization on Carbon Hard Spheres", J. Polym. Sci. A: Polym Chem., 2013, 51(15), 3314.
Venkataraman, P.; Tang, J.; Frenkel, E.; McPherson, G.; He, J.; Raghavan, S.; Kolesnichenko, V.; Bose, A.; John, V. "Attachment of a Hydrophobically Modified Biopolymer to the Oil-Water Interface in the Treatment of Oil Spills", ACS Appl. Mater. & Interfaces, 2013, 5(9), 3572.
Saha, A.; Nikova, A.; Venkataraman, P.; John,V.; Bose, A. "Oil Emulsification using Surface-Tunable Carbon Black Particles", ACS Appl. Mater. & Interfaces, 2013, 5(8), 3094.
Kucheryavy, P.; He, J.; John, V.; Maharjan, P.; Spinu, L.; Goloverda, G.; Kolesnichenko, V. "Superparamagnetic Iron Oxide Nanoparticles with Variable Size and Iron Oxidation State as Prospective Imaging Agents", Langmuir, 2013, 29(2), 71.
Katepalli, H.; John, V.; Bose, A. "The Response of Carbon Black Stabilized Oil-in-Water Emulsions to the Addition of Surfactant Solutions", Langmuir, 2013, 29(23), 6790.
Kapoor, Y.; Bengani, L.; Tan, G.; John, V.; Chauhan, A. "Aggregation and Transport of Brij Surfactants in p-HEMA Hydrogels", J. Coll. Interface Sci. 2013, 407, 390.
Wang, Y.; Sunkara, B.; Zhan, J.; He, J.; Miao, L.; McPherson, G.; Spinu, L.; John, V. "Synthesis of Submicrometer Hollow Particles with a Nanoscale Double Layer Shell Structure", Langmuir, 2012, 28(39), 13783.
John, G.; Jadhav, S.; Menon, V.; John, V. "Flexible Optics - A New Tale of Molecular Gels", Angewandte Chemie Intl. Ed. 2012, 52(8), 1760.
Li, X.; John, V.; He, G.; He, J.; Spinu, L,. "Magnetic TiO2-SiO2 Hybrid Hollow Spheres with TiO2 Nanofibers on the Surface, and their Formation Mechanism", J. Mater. Chem., 2012, 22(34), 17476. (cover article)
Ponnusamy, T.; Lawson, L.; Freytag, L.; Blake, D.; Ayyala, R.; John, V. "In Vitro Degradation and Release Characteristics of Spin Coated Thin Films of PLGA with a Breath Figure Morphology", Biomatter, 2012, 2(2), 1. (cover article)
Dhule, S.; Penformis, P.; John, V.; Pochampally, R. "Circumin-loaded Gamma Cyclodextrin Liposomal Nanoparticles as Delivery Vehicles for Osteosarcoma", Nanomedicine: Nanotechnology, Biology, and Medicine. 2012, 8(4), 440.
Venkataraman, P.; Sunkara, B.; St. Dennis, J.; He,J.; John, V.; Bose, A. "Water-in-Trichloroethylene Emulsions Stabilized by Uniform Carbon Microspheres", Langmuir, 2012, 28(2), 1058.
Sahiner, N.; Yu, H.; Tan, G.; He, J.; John, V.; Blake, D. Porous Acrylonitrile-based Submicron Polymers for UO2 Absorption in an Immunosensor Assay", ACS Applied Materials & Interfaces, 2012, 4(1), 163.
300 Lindy Boggs Center, Tulane University, New Orleans, LA 70118, T: 504-314-2914, F: 504-865-6744 email@example.com