Tuesday, September 25, 2012
101 Stanley Thomas Hall
Tulane University (Uptown)
Refreshments will be served
Katarzyna A. Rejniak, Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute
Intravascular transport of circulating tumor cells: biology, mechanics and modeling challenges
Metastasis to distant organs is an ominous feature of most malignant tumors, and it is the major cause of mortality. However, no more than 0.01% of circulating tumor cells (CTCs) is able to withstand all steps of a metastatic cascade, such as an escape from primary tumor mass into the blood stream, circulation with the blood flow and extravasation into the new site that can be subsequently colonized. The processes involved in tumor cells transport in circulation and their extravasation, i.e., their ability to leave the circulation system under the physiological blood flow, is still poorly understood. I will present the current biological understanding of the properties of CTCs and challenges in computational modeling of various modes of tumor cell translocation under the blood flow: from circulation to rolling, to crawling, to transmigration.
Center for Computational Science, Stanley Thomas Hall 402, New Orleans, LA 70118 firstname.lastname@example.org