Tuesday, October 29, 2013
316 Stanley Thomas Hall
Tulane University (Uptown)
Refreshments will be served
Richard Bertram, Florida State University
A Mathematical Model for Pancreatic Islet Oscillations and their Synchronization
Insulin is a key hormone for glucose uptake and utilization in the body. It is known to be pulsatile, with a period of about 5 min, and this pulsatility facilitates proper glucose homeostasis by the liver. We describe a mathematical model that has been developed over the past decade for the electrical activity, calcium handling, and metabolism of insulin-secreting b-cells within pancreatic islets. This Dual Oscillator Model consists of an oscillator involving ionic currents and calcium feedback, and a separate but coupled oscillator driven by oscillations in glycolysis. The model has been used successfully to make predictions that have been tested in the laboratory, as we discuss in this presentation. We also discuss theoretical and experimental work done to understand how the hundreds of thousands of physically disconnected islets in the pancreas synchronize their rhythms.
Center for Computational Science, Stanley Thomas Hall 402, New Orleans, LA 70118 email@example.com