Professor Jayawickramarajah Publications

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Selected Publications




Aryal, G.; Vik, R.; Khaleel, A.; Hunter, K.; Liming, H.; Jayawickramarajah, J.; Nau, W. Structural effects on guest binding in cucurbit[8]uril-perylene monoimide host-guest complexes. ChemistrySelect 2018, 3, 4699-4704. DOI: 10.1002/slct.201800696.



2018 Aryal Pub


Varner, C.; Zhou, X.; Leger, J. D.; Jayawickramarajah, J.; Rubtsov, I. V. Azido alkanes as convenient reporters for mobility within lipid membranes. Chemical Physics. 2018 DOI: 10.1016/j.chemphys.2018.05.020.





Zhou, X.;Su, X.; Pathak, P.; Vik, R.; Vinciguerra, B.; Isaacs, L.; Jayawickramarajah, J. Host-Guest tethered DNA transducer: ATP fueled release of a protein inhibitor from cucurbit[7]uril. J. Am. Chem. Soc.2017, 139, 13916-13921. DOI: 10.1021/jacs.7b07977.


2017 Zhou Pub




Aryal, G.; Battle, C. H.; Grusenmeyer, T. A.; Zhu, M.; Jayawickramarajah, J. A napthalimide derived fluorescence sensor for solid-phase screening of cucurbit[7]uril-guest interactions Chem Comm.2016, 52,2307-2310. DOI: 10.1039/C5CC08350H.


 Link: - !divAbstract 


  Chem. Comm. 2016-Jayawickramarajah, J.














Su, X.; Zhou, X.;Zhang, N.; Zhu, M.; Zhang, H.;Jayawickramarajah, J. A stable bidentate protein binder achieved via DNA self-assembly driven ligand migration. 2015, Chem Comm.DOI: 10.1039/c5cc03213j.


DOI: 10.1039/c5cc03213j



Chu, X.;Battle, C.;Zhang, N.; Aryal, G. H.;Jayawickramarajah, J. Bile acid conjugated DNA chimera that conditionally inhibits carbonic anhydrase-IIin the presence of microRNA-21. 2015, Bioconjugate Chemistry. 26, 8,1601-1612.DOI:10.1021/acs.bioconjchem.5b00231.




DOI: 10.1021/acs.bioconjchem.5b00231



Yue, Y.; Qasim, L. N.; Kurnosov, A. A.; Rubtsova, N. I.; Mackin, R. T.; Zhang, H.; Zhang, B.; Zhou, X.; Jayawickramarajah, J.; Burin, A. L.; Rubtsov, I. V. Band-selective energy transport in alkane oligomers: Toward controlling the transport speed. J. Phys. Chem. B. 2015,119, 21,6448-6456. DOI: 10.1021/acs.jpcb.5b03658.



DOI: 10. 1063/1.4916326




Rubtsova, N.; Nyby, C.; Zhang, H.; Zhang, B.; Zhou, X.; Jayawickramarajah, J.; Burin, A.; Rubtsov, I. Room-temperature ballistic energy transport in molecules with repeating units. J. Chem. Phys. 2015,142, 212412. DOI: 10.1063/1.4916326.




Zhu, M.; Aryal, G.; Zhang, N.; Zhang, H.; Schmehl, R.; Liu, X.; Hu, J.; Wei, J.; Jayawickramarajah, J. Host-guest interactions derived multilayer perylene diimide thin film constructed on a scaffolding porphyrin monolayer. Langmuir 2015, 31, 578-586. DOI: 10.1021/la504297w.


2015Langmuir 31




Loewen, G.; Jayawickramarajah, J.; Shan, B. Functions of LincRNA HOTAIR in lung cancer. J. Hematol. Oncol. 2014, 10. 7, 90-100. DOI: 10.1186/s13045-014-0090-4. Link: 

Su, X.; Kuang, L.; Battle, C.; Shaner, T.; Mitchell, B. S.; Fink, M. J.; Jayawickramarajah, J. A mild two-step method to construct DNA-conjugated silicon nanoparticles: Scaffolds for the detection of microRNA-21. Bioconjugate Chemistry. 2014, 25, 1739-1743. Link:



Zhuang, Y.; Nguyen, H. T.; Burow, M. E.; Zhuo, Y.; El-Dahr, S. S.; Yao, X.; Cao, S.; Flemington, E. K.; Nephew, K. P.; Fang, F.; Collins-Burow, B.; Rhodes, L. V.; Yu, Q.; Jayawickramarajah, J.; Shan, B. Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells.Molecular Carcinogenesis 2014. DOI: 10.1002/mc.22237.



Loewen, G.; Zhuo, Y.; Zhuang, Y.; Jayawickramarajah, J.; Shan, B. LincRNA HOTAIR as a novel promoter of cancer progression. J. Cancer Res. Updates 2014, 3 (3), 134-140.



Zhang, H.;Zhang, B.; Zhu, M.; Grayson, S.; Schmehl, R.; Jayawickramarajah, J. Water-soluble porphyrin nanospheres: Enhanced photo-physical properties achieved via cyclodextrin driven double self-inclusion, Chem. Comm. 2014,50, 4853-4855.DOI:10.1039/C4CC01372G.

Link: - !divAbstract



Zhang, B.; Zhang, H.; Myers, B. K.; Elupula, R.; Jayawickramarajah, J.; Grayson, S. Determination of polyethylene glycol end group functionalities by combination of selective reactions and characterization by matrix assisted laser desorption/ionization time of flight mass spectrometry. Anal. Chim. Acta. 2014. 816, 28-40.




2003 - 2013

Battle, C.; Chu, X.; Jayawickramarajah, J. Oligonucleotide-based systems for input-controlled and non-covalently regulated protein binding. Supramolecular Chemistry, 2013, 25, 848-862. (Pdf Article)

Zhang, N.; Chu, X.; Fathalla, M.; Jayawickramarajah, J. Photonic DNA-chromophore nanowire networks: Harnessing multiple supramolecular assembly modes, Langmuir, 2013, 29, 10796-10806. (Pdf Article

Lin, Z.; Zhang, N.; Jayawickramarajah, J.; Rubtsov, I. V. Ballistic energy transport along PEG chains: Distance dependence of the transport efficiency. Phys. Chem. Chem. Phys. 2012, 14, 10445-10454. (Pdf Article) Battle, C.; Jayawickramarajah, J. Supramolecular approaches for inhibition of protein-protein and protein/DNA interactions in Supramolecular Chemistry: From Molecules to Nanomaterials; Steed, J., Gale, P., Eds. John Wiley & Sons Ltd: Chichester, United Kingdom, 2012, pp 1885-1908. (Pdf Article

Harris, D. C.; Saks, B. R.; Jayawickramarajah, J. Protein-binding molecular switches via host-guest stabilized DNA hairpins. J. Am. Chem. Soc. 2011, 133, 7676-7679. (Pdf Article)

Mishur, R. J.; Griffin, M. E.; Battle, C. H.; Shan, B.; Jayawickramarajah, J.  Molecular recognition and enhancement of aqueous solubility and bioactivity of CD437 by β-cyclodextrin. Bioorg. Med. Chem. Lett. 2011, 21, 857-860.

 Fathalla, M.; Li, S.-C.; Neuberger, A. Schmehl, R.; Diebold, U.; Jayawickramarajah, J.Straightforward self-assembly of porphyrin nanowires in water: Harnessing adamantane/β-cyclodextrin interactions J. Am. Chem. Soc. 2010, 132, 9966-9967.


Fathalla, M.; Jayawickramarajah, J. Configurational isomers of a stilbene linked bis(porphyrin) tweezer: Synthesis and fullerene binding studies. Eur. J. Org. Chem. 2009, 6095-6099. (picked as “Eurbest” article by the editors and is the one of the most-accessed articles in Eur. J. Org. Chem. for November 2009).

Pierce, S. E.; Wang, J.; Jayawickramarajah, J.; Hamilton, A. D.; Brodbelt, J. S. Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats.. 15, 11244-11255.

Chem. Eur. J. 2009

Fathalla, M.; Li, S.-C.; Diebold, U. Alb, A.; Jayawickramarajah, J. Water-soluble nanorods self-assembled via pristine-C60 and porphyrin moieties.  Chem Comm. 2009, 4209-4211.


 Fathalla, M.; Lawrence, C.; Zhang, N.; Sessler, J. L.; Jayawickramarajah, J.  Base-pairing mediated non-covalent polymers. Chem. Soc. Rev. 2009. 38, 1608-1620.


 Rosenzweig, B. A.; Ross, N. T.; Tagore, D. M.; Jayawickramarajah, J.; Saraogi, l.; Hamilton, A. D. Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold. J. Am. Chem. Soc. 2009, 131, 5020-5021.


 Harris, D. C.; Chu, X; Jayawickramarajah, J. Protein recognition via oligonucleotide-linked small molecules: Utilization of  the hemin-binding aptamer. Supramol. Chem. 2009, 21, 316-323.


Harris, D. C.; Chu, X; Jayawickramarajah, J. DNA-small molecule chimera with responsive protein-binding ability. J. Am. Chem. Soc. 2008, 130,14950-14951.


Pierce, S. E.; Sherman, C. L.; Jayawickramarajah, J.; Lawrence, C. M.; Sessler, J. L.; Brodbelt, J. S. ESI-MS characterization of a novel pyrrole-inosine nucleoside that interacts with guanine bases. Anal. Chim. Acta. 2008, 627, 129-135.


Jayawickramarajah, J.; Tagore, D. M.; Tsou, K.; Hamilton, A. D.  Allosteric control of self-assembly: Modulating the formation of guanine quadruplexes through orthogonal aromatic interactions. Angew. Chem. Int. Ed. 2007, 46, 7583-7586. (picked as ‘hot-paper’ by the editors)


Tagore, D. M.; Sprinz, K. I.; Fletcher, S.; Jayawickramarajah, J.; Hamilton, A. D. Protein recognition and denaturation by self-assembling fragments on a quadruplex scaffold.  Angew. Chem. Int. Ed. 2007, 46, 223-225. (picked as ‘hot-paper’ by the editors)


Torres, T.; Gouloumis, A.; Sanchez, D.; Jayawickramarajah. J.; Seitz, W.; Guldi, D. M.; Sessler, J. L. Photophysical characterization of a cytidine-guanosine tethered phthalocyanine-fullerene dyad. Chem. Comm. 2007, 292-294.


Sessler, J. L.; Lawrence, C.; Jayawickramarajah, J. Molecular recognition via base-pairing. Chem. Soc. Rev. 2007. 36, 314-325.


Sessler, J. L.; Jayawickramarajah, J.; Gouloumis, A.; Pantos, G. D.; Torres, T.; Guldi, D. M. Guanosine and fullerene derived de-aggregation of a new phthalocyanine-linked cytidine derivative. Tetrahedron 2006, 62, 2123-2131.


Sessler, J. L.; Jayawickramarajah, JFunctionalized base-pairs: versatile scaffolds for self-assembly. Chem. Comm. 2005, 15, 1939-1949.


Sessler, J. L.; Jayawickramarajah, J.; Gouloumis, A.; Torres, T.; Guldi, D. M.; Maldonado, S.; Stevenson, K. J.  Synthesis and photophysics of a porphyrin-fullerene dyad assembled through Watson-Crick hydrogen bonding. Chem. Comm. 2005, 14, 1892-1894.


Sessler, J. L.; Jayawickramarajah, J.; Sherman, C. L.; Brodbelt, J. S. Enhancing Hoogsteen interactions: A pyrrole-containing purine nucleoside that competes with guanosine self-assembly.  J. Am. Chem. Soc. 2004, 126, 11460-11461.


Sessler, J. L.; Jayawickramarajah, J.; Sathiosatham, M.  Energy-and electron-transfer in supramolecular systems. In Encyclopedia of Supramolecular Chemistry; Atwood, J., Steed, J., Eds. Marcel Dekker: New York, 2004, pp 535-545.


Sessler, J. L.; Jayawickramarajah, J.; Sathiosatham, M.; Sherman, C. L.; Brodbelt, J. S. A novel guanosine-cytidine dinucleoside that self-assembles into a trimeric supramolecule. Org. Lett. 2003, 5, 2627-2630.

2015 Percival Stern Hall, 6400 Freret Street, New Orleans, LA 70118, 504-865-5573