Andrew A. Lackner, D.V.M., Ph.D.

Colorado State University DVM, 1984; University of California, Davis, PhD, 1988 Professor of Microbiology & Immunology and Pathology and Director, Tulane National Primate Research Center


Research Interests

Neurovirology, Neuroimmunology and Neuropathology with a focus on nonhuman primate models of human disease such as AIDS.

Representative Publications

Vinet-Oliphant H, Alvarez X, Buza E, Borda J, Mohan M, Aye PP, Tuluc F, Douglas SD, Lackner AA. Neurokinin-1 Receptor (NK1-R) Expression in the Brains of SIV-Infected Rhesus Macaques: Implications for Substance P in NK1-R Immune Cell Trafficking into the CNS. Am J Pathol. 2010; 177:1286-1297.

Ratai E-M, Pilkenton J, Greco JB, Lentz MR, Bombardier JP, Turk KW, He J, Joo C-G, Lee V, Westmoreland SV, Halpern E, Lackner AA, Gonzalez G: In Vivo Proton Magnetic Resonance Spectroscopy Reveals Region Specific Metabolic Responses to SIV Infection in the Macaque Brain, BMC Neuroscience 2009, 10:63 (PMC2711091)

Ivey NS, Renner NA, Moroney-Rasmussen T, Mohan M, Redmann RK, Didier PJ, Alvarez X, Lackner AA, MacLean AG: Association of FAK activation with lentivrus-iduced disruption of blood-brain barrier tight junciton-associated ZO-1protein organization, J Neurovirol 2009, 15:312-323. (PMC2896435)

Ryzhova E, Aye P, Harvey T, Cao W, Lackner A, Gonzalez-Scarano F: Intrathecal humoral responses are inversely associated with the frequency of SIV M-tropic variants in the CNS, J Virol 2009, 83:8282-8288 (PMC2715750)

Ivey NS, MacLean AG, Lackner AA. AIDS and the blood-brain barrier. J Neurovirol. 2009, 15:111-122 (PMC2744422)

Ramesh G, Borda JT, Dufour J, Kaushal D, Ramamoorthy R, Lackner AA, Philipp MT: Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells and glial and neuronal apoptosis, Am J Pathol 2008, 173:1415-1427 (PMC2570132)

Borda JT, Alvarez X, Mohan M, Hasegawa A, Bernandino A, Jean S, Aye P, Lackner AA: CD163, a marker of perivascular macrophages is upregulated by microglia in SIV encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood brain barrier, Am J Pathol 2008, 172:725-737

Borda JT, Alvarez X, Mohan M, Ratterree MS, Phillippi-Falkenstein K, Lackner AA, Bunnell BA: Clinical and immunopathologic alterations in rhesus macaques affected with globoid cell leukodystrophy, Am J Pathol 2008, 172:98-111

Yang GB, Qiu CL, Aye P, Shao Y, Lackner AA: Expression of serotonin transporters by peripheral blood mononuclear cells of rhesus monkeys (Macaca mulatta), Cell Immunol 2007, 248:69-76

Orandle MS, Veazey RS, Lackner AA: Enteric ganglionitis in rhesus macaques infected with simian immunodeficiency virus, J Virol 2007, 81:6265-6275

Chen MF, Westmoreland S, Ryzhova EV, Martin-Garcia J, Soldan SS, Lackner A, Gonzalez-Scarano F: Simian immunodeficiency virus envelope compartmentalizes in brain regions independent of neuropathology, J Neurovirol 2006, 12:73-89

Kim JP, Lentz MR, Westmoreland SV, Greco JB, Fuller RA, Ratai EM, He J, Aminipour S, Lackner AA, Masliah E, Gonzalez RG: Relationships between astrogliosis and 1H MRS measures of brain Cho/Cr and MI/Cr in a primate model. American Journal of Neuroradiology 2005, 26:752-759

Lentz MR, Kim JP, Westmoreland SV, Greco JB, Fuller RA, Ratai EM, He J, Sehgal PK, Halpern EF, Lackner AA, Masliah E, Gonzalez RG: Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain. Radiology 2005, 235:461-468

Maclean AG, Belenchia GE, Bieniemy DN, Moroney-Rasmussen TA, Lackner AA: Simian immunodeficiency virus disrupts extended lengths of the blood--brain barrier. J Med Primatol 2005, 34:237-242

Yang G-B, Lackner AA: Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity. J Neuroimmunol 2004, 146:46-49

Freeman LM, Mansfield KG, Goldin B, Woods M, Gualtieri L, Li W, Bussell S, Lackner A, Gorbach S: Body composition changes in the SIV-infected juvenile rhesus monkey. J Infec Dis 2004, 189:2010-2015

Greco JB, Westmoreland SV, Ratai EM, Lentz MR, Sakaie K, He J, Sehgal PK, Masliah E, Lackner AA, Gonzalez RG: In vivo 1H MRS of Brain injury and repair during acute SIV infection in the macaque model of NeuroAIDS. Magnetic Resonance in Medicine 2004, 51:1108-1114

Stevceva L, Moniuszko M, Alvarez X, Lackner AA, Franchini G: Functional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIMmac251-or simian -human immunodeficiency virus KU2-infected macaques. Virology 2004, 319:190-200

Fuller RA, Westmoreland SV, Ratai E, Greco JB, P. KJ, Lentz MR, He J, Sehgal PK, Masliah E, Halpern E, Lackner AA, Gonzalez RG: A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/Macaque model of neuroAIDS. BMC Neuroscience 2004, 5:10-23

Curiel TJ, Morris C, Brumlik M, Landry SJ, Finstad K, Nelson A, Joshi V, Hawkins C, Alarez X, Lackner A, Mohamadzadeh M: Peptides Identified through Phage Display Direct Immunogenic Antigen to Dendritic Cells. J Immunol 2004, 172:7425-7431

Apetrei C, Gormus B, Pandrea I, Metzger M, ten Haaft P, Martin LN, Bohm R, Alvarez X, Koopman G, Murphey-Corb M, Veazey RS, Lackner AA, Baskin G, Heeney J, Marx PA: Direct inoculation of SIVsm in Black Mangabey (Lophocebus aterrimus). First evidence of AIDS in a heterologous African species and different pathologic outcomes of experimental infection. J Virol 2004, In Press

Kim WK, Corey S, Chesney G, Knight H, Klumpp S, Wuthrich C, Letvin NL, Koralnik IJ, Lackner A, Veazey, RS, Williams K: Identification of T lymphocytes in simian immunodeficiency virus encephalitis: distribution of CD8+ T cells in association with CNS vessels and virus. J Neurovirol 2004, 10:315-325

Sestak K, Aye PP, Buckholt M, Mansfield KG, Lackner AA, Tzipori S: Quantitative evaluation of Enterocytozoon bieneusi infection in simian immunodeficiency virus-infected rhesus monkeys. J Med Primatol 2003, 32:74-81

Veazey R, Ling B, Pandrea I, McClure HM, Lackner A, Marx P: Decreased CCR5 expression on CD4+ T cells of SIV-infected sooty mangabeys. AIDS Res Hum Retro 2003, 19:227-233

Veazey RS, Marx PA, Lackner AA: Vaginal CD4+ T Cells Express High Levels of CCR5 and are Rapidly Depleted in Simian Immunodeficiency Virus Infection. J Infec Dis 2003, 187:769-776

Sestak K, Merritt CK, Borda J, Saylor E, Schwanberger SR, Cogswell F, Didier ES, Didier PJ, Plauche G, Bohm RP, Aye PP, Alexa P, Ward RL, Lackner AA: Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques. Infect Immun 2003, 71:4079-4086

Veazey RS, Lifson J, Pandrea I, Purcell J, Piatak M, Lackner AA: Simian immunodeficiency virus (SIV) infection in neonatal macaques. J Virol 2003, 77:8783-8792

Veazey RS, Lifson JD, Schmitz JE, Kuroda MJ, Piatak M, Pandrea I, Purcell J, Bohm R, Blanchard J, Williams KC, Lackner AA: Dynamics of simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues. J Med Primatol 2003, 32:194-200

Greco JB, Sakaie KE, Aminipour S, Lee PL, Chang LL, He J, Westmoreland S, Lackner AA, Gonzalez RG: Magnetic resonance spectroscopy: an in vivo tool for monitoring cerebral injury in SIV-infected macaques. J Med Primatol 2002, 31:228-36

MacLean AG, Orandle MS, MacKey J, Williams KC, Alvarez X, Lackner AA: Characterization of an in vitro rhesus macaque blood-brain barrier. J Neuroimmunol 2002, 131:98-103.

Orandle MS, MacLean AG, Sasseville VG, Alvarez X, Lackner A: Enhanced Expression of proinflammatory cytokines in the central nervous system is associated with neuroinvasion by simian immunodeficiency virus and the development of encephalitis. J Virol 2002, 76:5797-5802.

Ryzhova EV, Crino P, Shawyer L, Westmoreland SV, Lackner AA, Gonzalez-Scarano F: Simian immunodeficiency virus encephalitis: Analysis of envelope sequences from individual brain multinucleated giant cells and tissue samples. Virology 2002, 297:57-67

Ryzhova EV, Whitbeck C, Canziani G, Westmoreland SV, Cohen GH, Eisenberg RJ, Lackner A, Gonzalez-Scarano F: Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4. J Virol 2002, 76:7903-7909

Westmoreland S, Alvarez X, deBakker C, Aye P, Wilson ML, Williams KC, Lackner AA: Developmental expression patters of CCR5 and CXCR4 in the rhesus macaque brain. J Neuroimmunol 2002, 122:146-158.

Williams K, Schwartz A, Corey S, Orandle M, Kennedy W, Thompson B, Alvarez X, Brown C, Gartner S, Lackner A: Proliferating cellular nuclear antigen (PCNA) as a marker of perivascular macrophages in SIV encephalitis. Am J Pathol 2002, 161:575-585.

MacLean AG, Orandle MS, Alvarex X, Williams KC, Lackner AA: Rhesus macaque brain microvessel endothelial cells behave in a manner phenotypically distinct from umbilical vein endothelial cells. J Neuroimmunol 2001,118:223-232.

Orandle MS, Williams KC, MacLean AG, Westmoreland SV, Lackner AA: Macaques with rapid disease progression and SIV encephalitis have a unique cytokine profile in peripheral lymphoid tissues. J Virol 2001, 75:4448-4452.

Williams KC, Alvarex X, Lackner AA: Central nervous system (CNS) perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system. Glia 2001, 36:156-164.

Williams KC, Corey S, Westmoreland SV, Pauley D, Knight H, deBakker C, Alvarex X, Lackner AA: Perivascular macrophages are the primary cell type productively infected by SIV in the brain of macaques: Implications for the neuropathogenesis of AIDS. J Exp Med 2001, 193:905-915.

Gonzalez RG, Cheng LL, Westmoreland SV, Sakaie KE, Becerra LR, Lee PL, Masliah E, Lackner AA: Early brain injury in the SIV macaque model of AIDS. AIDS 2000, 14: 2841-2849.

Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD: Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: Implications for the neuropathogenesis of AIDS. J Immunol 1999, 163:1636-1646.

Simon MA, Ilyinskii PO, Baskin GB, Knight HY, Pauley DR, Lackner AA: Association of simian virus 40 with a central nervous system lesion distinct from progressive multifocal leukoencephalopathy in macaques with simian AIDS. Am J Pathol 1999, 154:437-446.

Westmoreland SV, Williams K, Simon M, Bahn M, Rullkoetter A, Elliott M, deBakker C, Knight H, Lackner AA: Neuropathogenesis of simian immunodeficiency virus in neonatal rhesus macaques. Am J Pathol 1999, 155:1217-1228.

Westmoreland SV, Halpern E, Lackner AA: Simian immunodeficiency virus encephalitis is rhesus macaques is associated with rapid disease progression. J Neurovirol 1998,4:260-268.

Westmoreland SV, Rottman JB, Williams KC, Lackner AA, Sasseville VG: Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with SIV encephalitis. Am J Pathol 1998, 152:659-665.

Lane JH, Sasseville VG, Smith MO, Vogel P, Pauley DR, Heyes MP, Lackner AA: Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation. J Neurovirol 1996, 2:423-432.

Lane JH, Tarantal AF, Pauley D, Marthas M, Miller CJ, Lackner AA: Localization of SIV nucleic acid and antigen in brains of fetal macaques inoculated with pathogenic SIV in utero. Am J Pathol 1996, 149:1097-1104.

Sasseville VG, Smith MM, Mackay CR, Pauley DR, Mansfield KG, Ringler DJ, Lackner AA: Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. Am J Pathol 1996, 149:1459-1467.

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