Tasker Faculty Photo_small

Jeffrey Tasker, Ph.D.

Catherine and Hunter Pierson Chair in Neuroscience
Professor of Cell and Molecular Biology

Website: The Tasker Lab

Dr. Tasker teaches NSCI 3310/6310 (Cellular Neuroscience) and NSCI 7110 (Graduate Neuroscience).

Research Interests

The Tasker lab uses brain-slice patch-clamp, genetic, immunochemical, and molecular biology approaches to study the neural circuit organization and electrical and molecular signaling of hypothalamic neuroendocrine cells and amygdalar neurons involved in the brain regulation of physiological homeostasis, stress, depression, obesity, and stress disorders such as posttraumatic stress and anxiety.

Representative Publications

Nahar, J., Haam, J., Chen, C., Glatzer, N.R., Jiang, Z., Muglia, L.J., Dohanich, G.P., Herman, J.P. and Tasker, J.G. (2015) Rapid non-genomic glucocorticoid actions in male mouse hypothalamic neuroendocrine cells are dependent on the nuclear glucocorticoid receptor. Endocrinology 156:2831-2842. doi: 10.1210/en.2015-1273. Epub 2015 Jun 10.

Solomon, M.B., Loftspring, M., de Kloet, A., Ghosal, S., Carvallho-Netto, E., Jankord, R., Flak, J.N., Wulsin, A.C., Krause, E.G., Zhang, R., Rice, T., McKlveen, J.,  Myers, B.,  Dolgas, C.M., Packard, B.A., Tasker, J.G. and. Herman, J.P. (2015) Neuroendocrine function following hypothalamic depletion of glucocorticoid receptors in male and female mice. Endocrinology 156:2843-2853. doi: 10.1210/en.2015-1276. Epub 2015 Jun 5.

Haam, J., Halmos, K.C. and Tasker, J.G. (2014) Nutritional state-dependent ghrelin activation of vasopressin neurons via retrograde trans-neuronal-glial stimulation of excitatory GABA circuits. Journal of Neuroscience 34: 6201-6213; doi: 10.1523/JNEUROSCI.3178-13.2014.

Morton, L.A., Popescu, I.R., Haam, J. and Tasker, J.G. (2014) Short-term potentiation of GABAergic synaptic inputs activates vasopressin, but not oxytocin neurones. Journal of Physiology 592:4221-4233. doi: 10.1113/jphysiol.2014.277293.

Boychuk, C.R., Zsombok, A., Tasker, J.G. and Smith, B.N. (2013) Rapid glucocorticoid-induced activation of TRP and CB1 receptors causes biphasic modulation of glutamate release in gastric-related hypothalamic preautonomic neurons. Frontiers in Neuroendocrine Science 7:3. doi: 10.3389/fnins.2013.00003.


Di, S., Popescu, I.  and Tasker, J.G.  (2013) Glial Control of Endocannabinoid Heterosynaptic Modulation in Hypothalamic Neuroendocrine Cells. Journal of Neuroscience 33:18331-18342; doi:10.1523/JNEUROSCI.2971-12.2013

Haam, J., Popescu, I.R., Morton, L.A., Halmos, K.C., Teruyama, R., Ueta, U. and Tasker, J.G.  (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. Journal of Neuroscience 32:572-582.

Chen, W., Cahoy, D.O., Tasker, J.G. and Chiu, A.W.L. (2012) Kernel Duration and Modulation Gain in Coupled Oscillator Model and Their Implications on the Progression of Seizures. Network: Computation in Neural Systems 23: 59-75. Epub 2012 May 9.

Zhang, T., Shi, W.-L., Tasker, J.G., Zhou, J.-R., Peng, Y.-L, Miao, C.-Y., Yang, Y.-J. and Jiang, C.-L. (2012) Dexamethasone induces rapid promotion of norepinephrine-mediated vascular smooth muscle cell contraction. Molecular Medicine Reports 7: 549-554. DOI: 10.3892/mmr.2012.1196.

Qiu J., Hindmarch C.C., Yao S.T., Tasker J.G., Murphy D. (2011) Transcriptomic Analysis of the Osmotic and Reproductive Remodeling of the Female Rat Supraoptic Nucleus. Endocrinology 152: 3483-3491.

Wardman, J.H., Berezniuk, I., Di, S., Tasker, J.G. and Fricker, L.D. (2011) ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS ONE 6(12): e28152. doi:10.1371/journal.pone.0028152

Popescu, I., Morton, L.A., Franco, A., Di, S., Ueta, Y. and Tasker, J.G. (2010) Synchronized bursts of miniature inhibitory postsynaptic currents. Journal of Physiology 588.6:939-951.

                Selected as "Editor's Choice" article in March issue of the Journal of Physiology

                Subject of Journal of Physiology Perspective:  Behrends, J.C. (2010) An encounter of the third kind without the usual suspects: coherent activation of asynchronous transmitter release independent of presynaptic excitation. J Physiol 588.7:1031.

Evanson, N.K., Tasker, J.G., Hill, M.N., Hillard, C.J., and Herman, J.P. (2010) Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology 151:4811-4819.

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