Prescott Deininger, Ph.D.

University of California, Davis, Physical Chemistry, 1978
Professor of Epidemiology


Research Interests

Studies involve human genomics, gene regulation and instability of the human genome in cancer. Special emphasis on neural-specific RNA polymerase III-derived RNAs.

Representative Publications

M. El-Sawy, S.P. Kale, C. Dugan, T.Q. Nguyen, V. Belancio, H. Bruch, A.M. Roy-Engel, P.L Deininger. (2005) Nickel stimulates L1 retrotransposition by a post-transcriptional mechanism. J. Mol. Biol. 354:246-57

Stephen L. Gasior, Melanie Palmisano, Prescott L. Deininger. (2005) Alu-linked hairpins efficiently mediate RNA interference with less toxicity than H1-expressed shRNAs. Anal Biochem. 349:41-8.

P. Deininger (2006) Alu elements. Genomic Disorders: The Genomic Basis of Disease (Lupski and Stankiewicz, eds) Human Press, pp 25-39.

S. Gasior, T. Wakeman, B. Xu, and P. Deininger. (2006) The Human LINE-1 Retrotransposon Creates DNA Double-Strand Breaks. J. Mol. Biol. 357:1383-93.

V. P. Belancio, D. Hedges, P. Deininger. (2006) LINE-1 RNA splicing and influences on mammalian gene expression. Nucleic Acids Res. 34:1512-21.

J. Xing, H. Wang, V.P. Belancio, R. Cordaux, P.L. Deininger and M.A. Batzer (2006) Emergence of new primate genes by retrotransposon-mediated sequence transduction. Proc. Natl. Acad. Sci. 103:17608-13.

V.P. Belancio, M. Whelton, and P. Deininger (2007) Requirements for polyadenylation at the 3’ end of LINE-1 elements. Gene 390, 98-107.

S. Gasior, G. Preston, D. Hedges, N. Gilbert, J. Moran and P. Deininger (2007) Characterization of pre-insertion loci of de novo L1 inserts. Gene 390, 190-198.

DJ Hedges and PL Deininger (2007) Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity. Mutat Res. 616, 46-59.

Belancio VP, Roy-Engel AM, Deininger P. (2008) The impact of multiple splice sites in human L1 elements. Gene 411:38-45.

Belancio VP, Hedges DJ, Deininger P. (2008) Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health. Genome Res 18:343-58.

SL Gasior and PL Deininger (2008) ERCC1/XPF limits L1 retrotransposition. DNA Repair 7:983-989 (2008) LINE-1 ORF1 protein enhances Alu SINE retrotransposition. Gene (in press)

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