S. Michal Jazwinski, Ph.D.

Stanford University, Biochemistry, 1975
Professor of Medicine
Director, Center for Aging


Dr. Jazwinski studies the genetics of aging.

Research Interests

Genetics of aging.

Recent Publications

Y.Y. Liu, G.A. Patwardhan, K. Bhinge, V. Gupta, X. Gu, S.M. Jazwinski.  Suppression of Glucosylceramide Synthase Restores p53-Dependent Apoptosis in Mutant p53 Cancer Cells.  Cancer Res. 71, 2276-2285 (2011).

E.M. Elliott, K.E. Cherry, J.S. Brown, E.A. Smitherman, S.M. Jazwinski, Q. Yu, J. Volaufova.  Working Memory in the Oldest-Old: Evidence from Output Serial Position Curves.  Mem. Cognit. 39, 1423-1434 (2011). 

M.V. Miceli, J. Jiang, A. Tiwari, J. Rodriguez-Quinones, S.M. Jazwinski. Loss of Mitochondrial Membrane Potential Triggers the Retrograde Response Extending Yeast Replicative Lifespan. Front. Gene. 2, 102 (2011).

K.E. Cherry, J. Silva Brown, L.D. Marks, S. Galea, J. Volaufova, C. Lefante, L.S. Su, D.A. Welsh, S.M. Jazwinski for The Louisiana Healthy Aging Study.  Longitudinal Assessment of Cognitive and Psychosocial Functioning after Hurricane Katrina and Rita: Exploring Disaster Impact on Middle-Aged, Older, and Oldest-Old Adults.  J. Applied Behavioral Research 16, 187-211 (2011).

S. Kim, X. Bi, M. Czarny-Ratajczak, J. Dai, D.A. Welsh, L. Myers, M.A. Welsch, K.E. Cherry, J. Arnold, L.W. Poon, S.M. Jazwinski.  Telomere Maintenance Genes SIRT1 and XRCC6 Impact Age-Related Decline in Telomere Length but Only SIRT1 Is Associated with Human Longevity.  Biogerontology 13, 119-131 (2012).

S.M. Jazwinski.  The Retrograde Response and Other Pathways of Interorganelle Communication in Yeast Replicative Aging.  Subcell. Biochem. 57, 79-100 (2012).

K.E. Cherry, J.S. Silva, E.J. Walker, E.A. Smitherman, E.O. Boudreaux, J. Volaufova, S.M. Jazwinski.  Semantic Encoding Enhances the Pictorial Superiority Effect in the Oldest-Old. Neuropsychol. Dev. Cogn. B. Aging Neuropsych. Cogn. 19, 319-337 (2012).

R. Hensley, P. Martin, J. Margrett, M. MacDonald, I.C. Siegler, L.W. Poon, S.M. Jazwinski, R.C. Green, M. Gearing, J.L. Woodard, M.A. Johnson, J.S. Tenover, W.L. Rodgers, D.B. Hausman, C. Rott, A. Davey, J. Arnold.  Life Events and Personality Predicting Loneliness among Centenarians:  Findings from the Georgia Centenarian Study.  J. Psychol. 146, 173-188 (2012).

J.M. Figueiredo, D.C. Rodrigues, R.C. Silva, C.M. Koeller, J.C. Jiang, S.M. Jazwinski, J.O. Previato, L. Mendonca-Previato, T.P. Urmenyi, N. Heise.  Molecular and Functional Characterization of the Ceramide Synthase from Trypanosoma cruzi.  Mol. Biochem. Parasitol. 182, 62-74 (2012).

Cho J, Martin P, Margrett J, MacDonald M, Johnson MA, Poon LW; Georgia Centenarian Study, Jazwinski SM, Green RC, Gearing M, Woodard JL, Tenover JS, Siegler IC, Rott C, Rodgers WL, Hausman D, Arnold J, Davey A.  Multidimensional Predictors of Fatigue among Octogenarians and Centenarians.  Gerontology 58, 249-257 (2012).

S.M. Jazwinski, A. Kriete.  The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction.  Front. Physiol. 3, 139 (2012).

Gupta V, Bhinge KN, Hosain SB, Zhong K, Gu X, Shi R, Ho MY, Khoo KH, Li SC, Li YT, Ambudkar SV, Jazwinski SM, Liu YY. Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells. J. Biol. Chem. 287, 37195-37205 (2012).

Stumpferl SW, Brand SE, Jiang JC, Korona B, Tiwari A, Dai J, Seo J-G, Jazwinski SM. Natural genetic variation in yeast longevity. Genome Res. 22, 1963-1973 (2012).

Kim S, Welsh DA, Cherry KE, Myers L, Jazwinski SM. Association of healthy aging with parental longevity. AGE 2012 Sep 18 [epub ahead of print]

Pellett AA, Myers L, Welsch M, Jazwinski SM, Welsh DA for The Louisiana Healthy Aging Study. Left atrial enlargement and reduced physical function during aging. J. Aging Phys. Act. 2012 Dec 10 [epub ahead of print]

S.M. Jazwinski.  The Retrograde Response: When Mitochondrial Quality Control Is Not Enough.  Biochimica et Biophysica Acta 1833, 400-409 (2013).

Kenney MC, Chwa M, Atilano SR, Pavlis JM, Falatoonzadeh P, Ramirez C, Malik D, Hsu T, Woo G, Soe K, Nesburn AB, Boyer DS, Kuppermann BD, Jazwinski SM, Miceli MV, Wallace DC, Udar N. Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS One 8, e54339 (2013).

Cherry KE, Walker EJ, Brown JS, Volaufova J, Lamotte LR, Welsh DA, Su LJ, Jazwinski SM, Ellis R, Wood RH, Frisard MI. Social Engagement and Health in Younger, Older, and Oldest-Old Adults in the Louisiana Healthy Aging Study (LHAS). J. Appl. Gerontol. 32, 51-75 (2013).

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