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Journals

 


Faculty Publications
 

Critical role for monocyte/macrophages in the rapid progression to AIDS in pediatric SIV-infected rhesus macaques

Sugimoto, C., K.M. Merino, A. Hasegawa, X. Wang, X. Alvarez, K. Mori, E.S. Didier, R.S. Veazey, M.J., Kuroda.  2017.  J. Virol. PMID: 28566378; PMCID: PMC5553179

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High turnover of tissue macrophages contributes to TB reactivation in SIV-infected rhesus macaques

Kuroda, M.J., C. Sugimoto, Y. Cai, K.M. Merino, S. Mehra, M.A. Arainga, C.C. Midkiff, X. Alvarez, E.S. Didier, D. Kaushal.  2017.   J. Infect. Dis. (in press Doi; 10.1093/infdis/jix625)

 

Role of monocyte/macrophages in HIV/SIV infection in adult and pediatric AIDS  

Merino, K.M, C. Allers, E.S. Didier, and M.J. Kuroda.  2017.  .  Front. Immunol. 8:1693 PMID: 29259605; PMCID: PMC5723290.

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Hydrocephalus subsequent to intrathecal administration of dextran in rhesus macaques (Macaca mulatta).

Dufour, J.P., K.E. Russell-Lodrigue, L. Doyle-Meyers, K.P. Falkenstein, R.V. Blair, E.S. Didier, N. Slisarenko, K.C. Williams, M.J. Kuroda.  2018.    Compar. Med.  (in press).




Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission

Fan Q, Nelson CS, Bialas KM, Chiuppesi F, Amos J, Gurley TC, Marshall DJ, Eudailey J, Heimsath H, Himes J, Deshpande A, Walter MR, Wussow F, Diamond DJ, Barry PA, Moody MA, Kaur A, Permar SR. Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) infection in a monkey model of congenital CMV transmission. Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00510-16. doi: 10.1128/CVI.00510-16. Pubmed PMCID: PMC5424243. 

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Simian Immunodeficiency Virus Targeting of CXCR3+ CD4+ T Cells in Secondary Lymphoid Organs Is Associated with Robust CXCL10 Expression in Monocyte/Macrophage Subsets.

Fujino M, Sato H, Okamura T, Uda A, Takeda S, Ahmed N, Schichino S, Shino T, Saito Y, Watanabe S, Sugimoto C, Kuroda MJ, Ato M, Nagai Y, Izumo S, Matsushima K, Miyazawa M, Ansari AA, Villinger F, Mori K. Simian Immunodeficiency Virus Targeting of CXCR3+ CD4+ T Cells in Secondary Lymphoid Organs is Associated with Robust CXXL10 Expression in Monocyte/Macrophage Subsets. J. Virol 2017 Jun 9;91(13. Doi: 10.1128/JVI.00439-17. Print 2017 Jul 1 PMID: 28424283 PMCID:PMC5469254 

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Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

Nelson C, Cruz D, Tran D, Bialas K. Stamper L, Huali W, Gilbert M, Blair R, Alvarez X, Itell H, Chen M, Deshpande A, Chiuppesi F, Wussow F, Diamond D, Vandergrift N, Walter M, Barry P, Cohen-Wolkowiez M, Koelle K, Kaur A, Permar S. Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys. JCI Insight 2017 2017;2(13:e94002. Doi: 10.1172/jci.insight.94002. PubMed PMID: 28679960 PMCID: PMC5499366  

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Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome


Merino KM, Allers C, Dider ES and Kuroda MJ. Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome. Front Immunol. 2017;8:1693. doi: 10.3389/fimmu.2017.01693. PubMed PMID: 29259605; PMCID: PMC5723290 

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Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques.


Sugimoto C, Merino KM, Hasegawa A, Wang X, Alvarez XA, Wakao H, Mori K, Kim WK, Veazey RS, Didier ES, Kuroda MJ. A Critical Role for Monocytes/Macrophages in the Rapid Progression to AIDS in Pediatric SIV-Infected Rhesus Macaques. J Virol 2017 May 31. doi: 10.1128/JVI.00379-17. PubMed PMD: 28566378 PMCID:55553179 

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Critical Role for Monocytes/Macrophages in Rapid Progression to AIDS in Pediatric Simian Immunodeficiency Virus-Infected Rhesus Macaques.

Sugimoto C, Merino KM, Hasegawa A, Wang X, Alvarez XA, Wakao H, Mori K, Kim WK, Veazey RS, Didier ES, Kuroda MJ.
J Virol. 2017 Aug 10;91(17). pii: e00379-17. doi: 10.1128/JVI.00379-17. Print 2017 Sep 1. Erratum in: J Virol. 2017 Oct 27;91(22):.  PMID:28566378

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Role of Monocyte/Macrophages during HIV/SIV Infection in Adult and Pediatric Acquired Immune Deficiency Syndrome.

Merino KM, Allers C, Didier ES, Kuroda MJ.
Front Immunol. 2017 Dec 5;8:1693. doi: 10.3389/fimmu.2017.01693. eCollection 2017. Review. PMID: 29259605

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Maintenance of AP-2 Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.

Schouest B, Weiler AM, Janaka SK, Myers TA, Das A, Wilder SC, Furlott J, Baddoo M, Flemington EK, Rakasz EG, Evans DT, Friedrich TC, Maness NJ.
J Virol. 2017 Dec 13. pii: JVI.01822-17. doi: 10.1128/JVI.01822-17. [Epub ahead of print] PMID: 29237831

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The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques.

Wu HL, Wiseman RW, Hughes CM, Webb GM, Abdulhaqq SA, Bimber BN, Hammond KB, Reed JS, Gao L, Burwitz BJ, Greene JM, Ferrer F, Legasse AW, Axthelm MK, Park BS, Brackenridge S, Maness NJ, McMichael AJ, Picker LJ, O'Connor DH, Hansen SG, Sacha JB.
J Immunol. 2018 Jan 1;200(1):49-60. doi: 10.4049/jimmunol.1700841. Epub 2017 Nov 17.
PMID: 29150562

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The Importance of Understanding MHC-I Diversity in Nonhuman Primate Models of Human Infectious Diseases.

Maness NJ.
Toxicol Pathol. 2017 Jan;45(1):157-160. doi: 10.1177/0192623316672072. Epub 2016 Oct 11. Review. PMID: 27729588

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In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.

Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, Golden NA, Gentry KM, Doyle-Meyers LA, Russell-Lodrigue KE, Didier PJ, Blanchard JL, Kousoulas KG, Lackner AA, Kalman D, Rengarajan J, Khader SA, Kaushal D, Mehra S.
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71. doi: 10.1073/pnas.1711373114. Epub 2017 Dec 18.  PMID:  29255022

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Translational Research in the Nonhuman Primate Model of Tuberculosis.

Foreman TW, Mehra S, Lackner AA, Kaushal D. 
ILAR J. 2017 May 31:1-9. doi: 10.1093/ilar/ilx015. [Epub ahead of print] PubMed PMID: 28575319.

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Hypoxia Sensing and Persistence Genes are Expressed during the Intra-granulomatous Survival of M. tuberculosis

Hudock TA, Foreman TW, Bandyopadhyay N, Gautam US, Veatch A, LoBato DN, Gentry KM, Golden NA, Cavigli A, Mueller M, Hwang SA, Hunter RL, Alvarez X, Lackner AA, Bader JS, Mehra S, Kaushal D.
Am J Respir Cell Mol Biol. 2017 May;56(5):637-647. doi: 10.1165/rcmb.2016-0239OC. PubMed PMID: 28135421; PubMed Central PMCID: PMC5449490.

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Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection.

Foreman TW, Veatch AV, LoBato DN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Lackner AA, Kousoulas KG, Khader SA, Kaushal D, Mehra S.
Am J Pathol. 2017 Dec;187(12):2811-2820. doi: 10.1016/j.ajpath.2017.08.014. Epub 2017 Sep 19.  PMID:  28935575

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LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytes by modulating mitochondrial signaling in an in-vitro granuloma model.

Phillips BL, Gautam US, Bucsan AN, Foreman TW, Golden NA, Niu T, Kaushal D, Mehra S.
PLoS One. 2017 Sep 7;12(9):e0180413. doi: 10.1371/journal.pone.0180413. eCollection 2017.  PMID: 28880895

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Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy.

Perez S, Johnson AM, Xiang SH, Li J, Foley BT, Doyle-Meyers L, Panganiban A, Kaur A, Veazey RS, Wu Y, Ling B.
J Neurovirol. 2017 Nov 27. doi: 10.1007/s13365-017-0594-0. [Epub ahead of print]
PMID:  29181724

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A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates.

Baker SM, Davitt CJH, Motyka N, Kikendall NL, Russell-Lodrigue K, Roy CJ, Morici LA.
Vaccines (Basel). 2017 Dec 9;5(4). pii: E49. doi: 10.3390/vaccines5040049. PMID: 29232837

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Mucosal bacterial dissemination in a rhesus macaque model of experimental brucellosis.

Russell-Lodrigue KE, Killeen SZ, Ficht TA, Roy CJ.
J Med Primatol. 2018 Feb;47(1):75-77. doi: 10.1111/jmp.12282. Epub 2017 Jun 2.
PMID:  28573738

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Peptide of Rhesus Rotavirus VP4 Protein Governs Cholangiocyte Infection and the Murine Model of Biliary Atresia.

Mohanty SK, Donnelly B, Lobeck I, Walther A, Dupree P, Coots A, Meller J, McNeal M, Sestak K, Tiao G.
The SRL Hepatology. 2017 Apr;65(4):1278-1292. doi: 10.1002/hep.28947. PMID: 27859498. PubMed Central:  PMCID:  PMC5360466




Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques.

Mahalingam R, Kaufer BB, Ouwendijk WJD, Verjans GMGM, Coleman C, Hunter M, Das A, Palmer BE, Clambey E, Nagel MA, Traina-Dorge V.
J Virol. 2018 Jan 17. pii: JVI.02253-17. doi: 10.1128/JVI.02253-17. [Epub ahead of print]
PMID: 29343566

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image: Cover, Immununological Review

Mucosal immunology of HIV infection.

Xu H, Wang X, Veazey RS. Immunol Rev. 2013 Jul;254(1):10-33. doi: 10.1111/imr.12072. Review. PMID: 23772612

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image: Cover, Journal of Infectious Desease

Granuloma correlates of protection against tuberculosis and mechanisms of immune modulation by Mycobacterium tuberculosis.

Mehra S, Alvarez X, Didier PJ, Doyle LA, Blanchard JL, Lackner AA, Kaushal D.:
J Infect Dis. 2013 Apr;207(7):1115-27. doi: 10.1093/infdis/jis778. Epub 2012 Dec 18. PMID: 23255564

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image: Cover, PLOS Journal

Increased monocyte turnover from bone marrow correlates with severity of SIV encephalitis and CD163 levels in plasma.

Burdo TH, Soulas C, Orzechowski K, Button J, Krishnan A, Sugimoto C, Alvarez X, Kuroda MJ, Williams KC.:
PLoS Pathog. 2010 Apr 15;6(4):e1000842. doi: 10.1371/journal.ppat.1000842. PMID: 20419144

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image: Cover, Journal of Pathology

Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy.

Snook ER, Fisher-Perkins JM, Sansing HA, Lee KM, Alvarez X, MacLean AG, Peterson KE, Lackner AA, Bunnell BA.:
Am J Pathol. 2014 Feb;184(2):382-96. doi: 10.1016/j.ajpath.2013.10.011. Epub 2013 Dec 4. PMID: 24316110

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image: Cover, Infection and Immunity

Toll-Like Receptors: Insights into Their Possible Role in the Pathogenesis of Lyme Neuroborreliosis.

Andrea L. F. Bernardino, Tereance A. Meyers, Xavier Alvarez, Atsuhiko Hasegawa, and Mario T. Philipp:
Infection and Immunity 2008 October, Volume 76, Number 10

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image: Cover, American Journal of Pathology

CD163, a Marker of Perivascular Macrophages, Is Up-Regulated by Microglia in Simian Immunodeficiency Virus Encephalitis after Haptoglobin-Hemoglobin Complex Stimulation and Is Suggestive of Breakdown of the Blood-Brain Barrier.

Juan T. Borda, Xavier Alvarez, Mahesh Mohan, Atsuhiko Hasegawa, Andrea Bernardino, Sherrie Jean, Pyone Aye and Andrew A. Lackner:
Am J Pathol 2008 March, 172:725-737

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image: Cover, Journal of Exp Med

Perivascular macrophages are the primary cell type productively infected by SIV in the brain of macaques: Implications for the neuropathogenesis of AIDS.

Williams KC, Corey S, Westmoreland SV, Pauley D, Knight H, deBakker C, Lackner AA:
J Exp Med 2001, 193:905-915

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image: Cover, American Journal of Pathology

Proliferating cellular nuclear antigen (PCNA) as a marker of perivascular macrophages in SIV encephalitis.

Williams K, Schwartz A, Corey S, Orandle M, Kennedy W, Thompson B, Alvarez X, Brown C, Gartner S, Lackner AA:
Am J Pathol 2002, 161:575-585

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image: Cover, Journal of Virology

Plasma membrane topology of syncytial domains of herpes simplex virus type 1 glycoprotein K (gK): the UL20 protein enables cell surface localization of gK but not gK-mediated cell-to-cell fusion.

Foster TP, Alvarez X, Kousoulas KG.
J Virol. 2003 Jan;77(1):499-510.

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image: Cover, Virology

Overexpression of gK in gK-transformed cells collapses the Golgi apparatus into the endoplasmic reticulum inhibiting virion egress, glycoprotein transport, and virus-induced cell fusion.

Foster TP, Rybachuk GV, Alvarez X, Borkhsenious O, Kousoulas KG.
Virology. 2003 Dec 20;317(2):237-52.

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image: Cover,

Immunoglobulin-A nephropathy with crescentic glomerulonephritis in a pigtailed macaque (Macaca nemestrina).

Borda JT, Pauley DR, MacKey JJ, Alvarez X, Simon MA, Klumpp SA.
Vet Pathol. 2004 Jan;41(1):44-9.

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image: Cover, American Journal of Pathology

Cell tropism of simian immunodeficiency virus in culture is not predictive of in vivo tropism or pathogenesis.

Borda JT, Alvarez X, Kondova I, Aye P, Simon MA, Desrosiers RC, Lackner AA:
Am J Pathol 2004, 165:2111-2122

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image: Cover, Journal of Leukoc Biology

Monocyte/macrophage traffic in HIV and SIV encephalitis.

Kim WK, Corey S, Alvarez X, Williams K.
J Leukoc Biol. 2003 Nov;74(5):650-6.

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image: Cover, Laboratory Investigation

Computer emulation of thin-section electron microscopy predicts an envelope associated icosadeltahedral capsid for human immunodeficiency virus.

Marx, P.A., R.J. Munn, and K.I. Joy.
Laboratory Investigation 1988;58:(1):112-118

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image: Cover, Nature Medicine

Progesterone Implants Enhances SIV Vaginal Transmission and Early Virus Load.

Marx, P.A., A.I. Spira, A. Gettie, P.J. Dailey, R.S. Veazey, A.A. Lackner, C.J. Mahoney, C.J. Miller, L.E. Claypool, D.D. Ho and N.J. Alexander:
Nature Medicine, 1996;2:1084-1089

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The TNPRC is a division of Tulane University (985) 871-6201 tnprc@tulane.edu