Nine Premier Scientific Groups Release White Paper on the Critical Role of Nonhuman Primates (NHPs) in Scientific and Medical Research

Posted: 13 Sep 2016

The paper highlights the essential role NHPs play in finding treatments for serious and life-altering conditions such as Alzheimer’s disease, cancer, Zika virus, HIV/AIDS and Parkinson’s disease.



TNPRC investigations into Tuberculosis and HIV co-infection

Posted: 13 Sep 2016

A TNPRC-led study investigates the immunological mechanisms that control the pathologies of a macaque model of human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), in individuals infected with both diseases. HIV and Mtb are the two most deadly infectious agents of humanity. One in three people are latently Mtb infected, but latent Mtb can transform into active TB. Co-infection with HIV, which can lead to acquired immunodeficiency syndrome (AIDS), and Mtb speeds the progression of both infections, a process likely driven by a depletion of CD4+ T cells. To study the immunological regulation of latent TB infection by HIV, Deepak Kaushal and colleagues at the TNPRC, Albert Einstein College of Medicine, LSU School of Veterinary Medicine, and Washington University School of Medicine infected macaques with Mtb and simian immunodeficiency virus, mimicking Mtb and HIV co-infection in humans. In a majority of animals, Mtb replication rapidly reactivated and progressed to active tuberculosis, and pathologies associated with simian immunodeficiency virus increased. Despite the decrease in pulmonary CD4+ T cells in all co-infected macaques, a third of the animals maintained tuberculosis latency. For this cohort, an increase in protective immune responses, primarily mediated by increased CD8+ and profoundly enhanced B cell responses, was associated with limited Mtb replication. Hence, this investigation points to a greater role of these immune functions in the maintenance of latency. These findings, recently published by the Proceedings of the National Academy of Sciences, USA, may provide insights into natural immunity to Mtb and could help guide the development of vaccines and immunotherapies for tuberculosis and AIDS. Based on our data, future TB vaccination strategies should incorporate the elicitation of CD8+ and B cell responses as objectives.


Research could help search for birth defect vaccine

Posted: 20 Oct 2015

Researchers at Tulane National Primate Research Center (TNPRC) and Duke University have developed a new model that could bring science one step closer to developing a vaccine against congenital cytomegalovirus (CMV), one of the world's leading infectious causes of birth defects. 


Experimental Aerosol TB Vaccine Protects Monkeys, NIH-Funded Researchers Find

Posted: 16 Oct 2015

Researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have developed an investigational aerosol tuberculosis (TB) vaccine that induced potent immune responses in a small number of rhesus macaques and protected them against pulmonary infection with Mycobacterium tuberculosis(Mtb). The findings appear in Nature Communications.


Tulane Researchers Working on New Tuberculosis Vaccine

Posted: 15 Oct 2015

Researchers at the Tulane National Primate Research Center (TNPRC) are leading efforts to find a new vaccine for tuberculosis, one of the world's deadliest diseases. Tuberculosis, a contagious infection of the lungs, affected more than nine million people in 2013, killing more than one million.


The Search for Persisters

Posted: 24 Sep 2015

It starts with a tick bite. This may be followed by the characteristic bullseye rash. And then the other symptoms of Lyme disease appear. Fever, fatigue, body aches, and headaches can all set in.


Animal research crucial to creating AIDS treatments

Posted: 24 Jul 2015

Scientists in Philadelphia may be on the cusp of curing AIDS.


Animal Testing and Its Gifts To Humans

Posted: 22 May 2015

Patients with aggressive brain tumors finally have reason for hope. Thanks to the work of scientists and physicians at Duke University, an experimental new treatment for glioblastoma multiforme, or GBM—an aggressive tumor that kills about 12,000 people in the U.S. each year—is saving the lives of patients who, just months ago, had little hope of survival.


Bay Area Lyme Foundation's LymeAid® Brings Celebrities and Scientists Together To Help Accelerate Medical Breakthroughs for Lyme Disease

Posted: 22 May 2015

PORTOLA VALLEY, Calif., May 19, 2015 /PRNewswire/ -- On Sunday, May 17, Bay Area Lyme Foundation, the leading national nonprofit funder of innovative Lyme disease research, hosted more than 400 celebrities, philanthropists and noteworthy scientists at the third annual LymeAid®. The benefit dinner and concert raised approximately $600,000, of which 100% will go directly to fund research for Lyme disease. More than 300,000 Americans are diagnosed with this potentially debilitating disease each year.



Statement by NIH in Response to Concerns about Non-Human Primates in Research, January 26, 2015

Research with non-human primates and other animal species is key to helping us understand and improve human health in a multitude of ways, including the development of treatments and interventions. Read more...

Ricin vaccine shows promise in pilot study.

New Wave, November 5, 2014

A recent study at the Tulane National Primate Research Center showed for the first time that an experimental vaccine could completely protect nonhuman primates exposed to deadly ricin toxin, a potential bioterrorism agent. Read more...

"Animal Rights … Or Wrongs?" the next edition of "Nick News with Linda Ellerbee," on Tuesday, July 1 at 8 p.m.

Nick News with Linda Ellerbee, July 1, 2014

Animal research will be the topic of the children's program Nick News with Linda Ellerbee on the Nickelodeon Channel 8pm EDT on Tuesday July 1 (check your local cable listings). AMP Board Chair Cindy Buckmaster was interviewed extensively for the segment, which will also include video from Baylor College of Medicine. Keep in mind that the animal rights position will also be covered. Children's range of opinions on the issue will be explored by host Linda Ellerbee. An advance synopsis of the episode is available online. Read more...

Your Call: Should animals be used for scientific testing?

KALW, San Francisco, CA, June 15, 2014

Radio Debate on Animal Research. The "Your Call" radio program, originating on KALW in San Francisco, featured a fascinating nearly hour long debate this week on animal research between Michael Conn, Senior Vice President for Research and Associate Provost at Texas Tech University Health Sciences Center & co-author of "The Animal Research War" and Robert Jones, an Assistant Professor of Philosophy at California State University at Chico. Listen to it here, and then leave a comment if you're so inclined. Listen now...

Now in clinical trials, a new injectable drug could provide long-term HIV protection

The Gambit Weekly, May 05, 2014

New Orleans ranks third among U.S. cities in HIV case rates, according to the most recent National HIV Surveillance report from the Centers for Disease Control and Prevention (CDC). However, New Orleans also is the site of research for a promising new drug that could prevent HIV infections. The Tulane National Primate Research Center, GlaxoSmithKline, ViiV Healthcare and the Aaron Diamond AIDS Research Center collaborated on a study of the new drug. Dr. Rudolf Bohm, associate director and chief veterinary medical officer at the Tulane National Primate Research Center, discusses the drug and its implications. Read article...

The Global Search for Education: More Research - Ticks

The Huffington Post, Oct 16, 2013

A team of scientists led by Dr. Monica E. Embers of the Tulane National Primate Research Center and Dr. Stephen W. Barthold, Director of the Center of Comparative Medicine at the University of California at Davis, carried out two experiments last year on rhesus macaques (monkeys) to determine whether Borrelia persists after antibiotic treatments. Read article...

Animals & Research: Think How Far We've Come

Novartis, April 29, 2011

Animal research is an important part of the research process when developing new treatments and medicines for patients. No one likes the idea, but as science has not evolved enough to make animal research unnecessary - for now, this is how we make sure medicines are safe.

America's Other Most Wanted: An animal rights extremist makes the FBI list

The Wall Street Journal, May 18, 2011

Now that Osama bin Laden is dead, the FBI's "Ten Most Wanted Terrorists" list is down to nine. Eight are wanted for aiding al Qaeda, attacking federal facilities, bombing the USS Cole, or committing air piracy - clearly public enemies, all. But the last one on the list is different. Read article...

Tulane President Cowen honors animal care technician George Cole for 45 years of service

The New Wave, March 25, 2011

The other 45-year honoree is George Cole, an animal care technician at the Tulane National Primate Research Center. Read article...

Animal research: Battle scars

Nature, February 23, 2011

This week, the journal Nature takes a look at the complicated case of animal activism and its effects on scientific research, publishing the results of a poll of 980 biomedical scientists from around the world. Read article...

Homing In on the Hideouts of HIV

amfAR, January 14, 2011

HIV infection has never been eradicated in patients by antiretroviral therapy (ART), regardless of the length of their therapy. amfAR-funded researcher Dr. Binhua Ling has now uncovered a major reservoir for these latent viruses. Read article...

AIDS Virus Has an Ancient History

Discover, January/February 2011

HIV is a newcomer among human pathogens, having caused the first known cases of AIDS within the past few decades. So scientists suspected that SIV, the primate virus that spawned HIV, was just a few hundred years older. Tulane University virologist Preston Marx published research in September that suggests otherwise. Read article...

Mesenchymal-Lineage Stem Cells Have Pronounced Anti-Inflammatory Effects in the Twitcher Mouse Model of Krabbe's Disease

This study evaluates the effect of intracerebroventricular administration of mesenchymal stem cells derived from adipose tissue and bone marrow on the pathology of Krabbe's disease. [Stem Cells] Read Abstract

AIDS Virus Lineage Much Older Than Previously Thought

ScienceDaily, September 19, 2010

An ancestor of HIV that infects monkeys is thousands of years older than previously thought, suggesting that HIV, which causes AIDS, is not likely to stop killing humans anytime soon, finds a study by University of Arizona and Tulane University researchers.

Read ScienceDaily article
Read The New York Times article
Read The New Wave article

NHLBI establishes one of the five nation-wide centers for TB systems biology at the TNPRC

The National Heart Lung and Blood Institute (NHLBI) recently awarded a 3.1 million dollar grant to researchers based at the Tulane National Primate Research Center (TNPRC), establishing one of the five nation-wide Centers for Tuberculosis Systems Biology. Deepak Kaushal, PhD, Assistant Professor of Microbiology and Immunology and a member of the Division of Bacteriology & Parasitology at the TNPRC is the principal investigator of the grant, which includes Drs Andrew A. Lackner, DVM, PhD, Rudolph P. Bohm, DVM, Kasi Russell-Lodrigue, DVM, PhD, Chad J. Roy, PhD (all from TNPRC), Michelle R. Lacey, PhD (from Tulane University), Carol Mason, MD and Juzar Ali, MD (from Louisiana State University School of Medicine), as co-investigators.

The grant is titled "Transcriptomics of Tuberculosis Latency and Reactivation in Primates". The center will leverage the nonhuman primate model of TB to study aspects of disease that allow the causative bacteria to persist in nonhuman primate lungs for long periods of time. Further, the group will study gene networks which allow the disease to reactivate in response to AIDS co-infection. Mathematical models generated from these data will be tested in primates as well as in lung samples derived from human patients of TB and TB/AIDS co-infection.

The other four Centers for Tuberculosis Systems Biology are at Case Western Reserve University, University of Pittsburg, University of Medicine and Dentistry, New Jersey and Johns Hopkins School of Medicine. A unique aspect of these centers would be the highly collaborative nature of the research. Each team comprises of microbiologists, molecular biologists, veterinarians, pathologists, infectious disease/pulmonary physicians, as well as mathematicians/statisticians. A data coordinating center based at the University of Washington will coordinate the exchange and sharing of data between the five centers, allowing for a cross-talk between different teams and exchange of ideas.

The Age of Pandemics

The Wall Street Journal, May 2, 2009

The threat of deadly new viruses is on the rise due to population growth, climate change and increased contact between humans and animals. What the world needs to do to prepare.

In 1967, the country's surgeon general, William Stewart, famously said, "The time has come to close the book on infectious diseases. We have basically wiped out infection in the United States." This premature victory declaration, perhaps based on early public health victories over 19th-century infectious diseases, has entered the lore of epidemiologists who know that, if anything, the time has come to open the book to a new and dangerous chapter on 21st-century communicable diseases. Read more...

Exploring the Potential of HIV Microbicides

NCRR Reporter, Winter 2007

As the number of HIV-infected women escalates worldwide, vaginal microbicides may help slow the spread of AIDS.

At the Tulane NPRC, another NCRR-funded primate center, Ronald Veazey and his colleagues are testing a promising new type of microbicide called a fusion inhibitor. These agents inhibit infection in a specific and targeted way by preventing the binding, or fusion, between glycoprotein molecules on the outercoat of HIV particles and the receptors for those glycoproteins on the surface of immune cells. Read more (PDF)...

Secret To AIDS Resistance Is In The Blood

Medical News Today, February 11, 2007

The absence of a specific marker in the blood and tissues of certain monkeys may be part of the key to understanding how they can be infected for years with SIV, the primate version of HIV, and never develop AIDS, according to research published by Tulane University pathologist Ivona Pandrea in the scientific journal Blood. Read more...

CROI covers advancements from start to finish

IAVI Report, March 2006, Kristen Jill Kresge

Highlights of recent HIV meeting run gamut from basic science to HIV prevention and vaccine research.

The 13th Conference on Retroviruses and Opportunistic Infections (CROI), which took place from 5-8 February, often struck a historic chord as many plenary and keynote speakers acknowledged the passage of important landmarks in the battle against the AIDS pandemic. Read more...

AIDS resistance secret may be in blood, February 12, 2007

U.S. scientists say the absence of a specific marker in the blood and tissues of certain monkeys might be part of the key to understanding AIDS resistance.

Tulane University pathologist Ivona Pandrea and colleagues are investigating why monkeys infected for years with simian immunodeficiency virus, the primate version of the human immunodeficiency virus, never develop AIDS. Read more...

Study looks at the ability of some monkey species to resist developing AIDS, March 7, 2005

The Tulane National Primate Research Center received a five-year grant of more than $2 million from the National Institute of Allergy and Infectious Diseases to study the ability of some monkey species to resist developing AIDS. The study seeks to answer the question of how African green monkeys, when infected with SIV (simian immunodeficiency virus, the monkey equivalent of HIV) are resistant to the development of AIDS, compared to humans and other monkeys. Read more...

Specific marker in blood may hold secret to AIDS resistance

The New Wave, March 23, 2007

A Tulane University pathologist suggests that the absence of a specific marker in the blood and tissues of certain monkeys may be part of the key to understanding how they can be infected for years with SIV, the primate version of HIV, and never develop AIDS. Read more...

AIDS resistance secret may be in blood

United Press International, February 12, 2007

U.S. scientists say the absence of a specific marker in the blood and tissues of certain monkeys might be part of the key to understanding AIDS resistance. Tulane University pathologist Ivona Pandrea and colleagues are investigating why monkeys infected for years with simian immunodeficiency virus, the primate version of the human immunodeficiency virus, never develop AIDS. Read more...

Gut Warfare

Nature Medicine, Vol. 13, No. 2, Feb 2007

Far from the unhurried killer it seemed to be, HIV is a swift assassin, gutting the body's immune system within days of infection. Erika Check finds out how this new paradigm is transforming AIDS research.

HIV is supposed to be a slow and stealthy killer. For years, scientists have thought the virus begins its assault in the blood, destroying just a few of its favorite targets — specialized immune cells called CD4 T-helper cells, which anchor the body's defenses against infections. Read more...

Father of animal activism backs monkey testing

The Sunday Times - Britain, November 26, 2006, Gareth Walsh

The father of the modern animal rights movement has endorsed the use of monkeys in research by an Oxford professor at the centre of anti-vivisection protests.

Peter Singer, who is widely admired by activists for writing the seminal work on animal rights, says giving the primates Parkinson's disease was "justifiable" because of the benefits it subsequently brought to thousands of human patients. Read more...

Animal guru gives tests his blessing

The Observer (UK), November 26, 2006

Monkey research has benefits, equal rights philosopher admit. One of the most important figures in the animal rights movement has publicly backed the use of living creatures in medical experiments. The endorsement - by the philosopher Peter Singer, who coined the phrase Animal Liberation and whose Seventies book on the subject led to the creation of the animal rights movement - has surprised observers. Read more...

What Felix the monkey taught me about animal research

Daily Mail UK, November 26, 2006

The research assistant, a thin, sallow man in chinos and a white shirt, greets me at the door. We have met before, but still he is jumpy and full of suspicion. "Hi", he says nervously. He glances over my shoulder, checks that nobody is watching us, then leads me quickly across the foyer and down a set of stairs. After two flights, we turn right, down a long corridor and through a series of card-swiped locked doors. Once at the end of the corridor, we twist, first left, then right, then left again. Then down another flight of stairs. In all, we walk for about seven minutes until, finally, we reach an unmarked door. The assistant swipes his security pass and ushers me inside. It is quiet, but I am hit by a thick, fetid smell, reminiscent of a hamster's cage. I am given green overalls and plastic shoe guards and led into a room about 10ft square. The smell is even more pungent. "This," says the research assistant, "is where the monkeys live." Read more...

Primate Center Hosts Veterinary Interns

The New Wave, August 1, 2006, Madeline Vann

Students from a variety of backgrounds find their way to the Tulane National Primate Research Center, nestled among the tall pines of the north shore of Lake Pontchartrain, for a Summer Research Fellowship Program. This year, seven students are interning with researchers on various projects from observing primate social behavior to analyzing cells and tissue in the lab.

"I thought it was a great opportunity to see the different levels of work in a veterinary environment. There aren't many places like this," says veterinary medicine student Doty Kempf from Louisiana State University. Kempf is spending the summer working in the lab of Tulane researcher Ronald Veazey, while fellow vet student Khush Banajee is shadowing veterinarians at the center.

"I am doing a lot of procedures that I would not have been able to do in another setting," says Banajee. Read more...

New Approach to HIV Prevention

The New Wave, November 1, 2005, Fran Simon

Research with female monkeys at the Tulane National Primate Research Center has for the first time shown that three different anti-viral agents in a vaginal gel protect the animals against an HIV-like virus.

The research suggests that a microbicide using compounds that inhibit the processes by which HIV attaches to and enters target cells could potentially provide a safe, effective and practical way to prevent HIV transmission in women, according to study investigators. The study, published online Oct. 30 in the journal Nature, was funded principally by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. Read more...

Primate Center Thrives

The New Wave, October 21, 2005, Fran Simon

The Tulane National Primate Research Center isn't just surviving, it's thriving. The center received notice that the National Center for Research Resources of the National Institutes of Health awarded two grants of $4 million each for new construction and expansion of the current breeding facility. In addition, the primate center received more than $1.6 million to support research training in experimental medicine and pathology to prepare veterinarians for careers in biomedical research. The grant proposals were submitted before Hurricane Katrina hit Louisiana. Read more...

The TNPRC is a division of Tulane University (985) 871-6201