Prediction of T-helper epitopes in Y. pestis V-antigen

Last modified 10/21/10.

landry@tulane.edu

Epitopes were predicted to be excluded from the conformtionally flexible segments of the V-antigen 3D structure (PDB:1R6F, Derewenda et al. 2004).  The method of identifying flexible protein segments is described by Melton and Landry, 2008.



Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS,
Waugh DS. The structure of Yersinia pestis V-antigen, an essential virulence
factor and mediator of immunity against plague. Structure. 2004 Feb;12(2):301-6.
PubMed PMID: 14962390.

Melton SJ, Landry SJ. Three dimensional structure directs T-cell epitope
dominance associated with allergy. Clin Mol Allergy. 2008 Sep 15;6:9. PubMed
PMID: 18793409; PubMed Central PMCID: PMC2553403

V-antigen prediction

Predicted Epitope list

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