Yu-Teh Li, Ph.D.
University of Oklahoma, 1963
Professor of Biochemistry
Glycobiology-Catabolism
of Glycoconjugates
Yu-Teh Li, Ph.D.
University of Oklahoma, 1963
Professor of Biochemistry
Glycobiology-Catabolism
of Glycoconjugates
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Dr. Yu-Teh Li and his wife, Dr.
Su-Chen Li, have been working as a team in the field of glycobiology
for over three decades. The two major projects of their laboratory are:
(i) biochemical studies of inborn lysosomal diseases, and (ii)
studies of biomedically useful glycosidases. S.-C. Li is in charge of
project (i) and Y.-T. Li is responsible for project (ii). The long-standing interests of Project (ii) in
Drs. Li's laboratory have been on the identification and characterization
of unique and biomedically useful glycosidases and to make them available
to other investigators. They have discovered several novel and useful
glycosidases and have contributed significantly to the use of glycosidases
to study the structure, function and catabolism of glycoconjugates. Several
commercially available glycosidases were developed based on the methods
established in their laboratory. Their recent work includes KDN-sialidases
[J. Biol. Chem. (1999) 274: 31974] and a novel endo-beta-galactosidase
that liberates the disaccharide GlcNAc-alpha-1,4Gal from glycans specifically
expressed in gastric gland mucous cell-type mucin [J. Biol. Chem.
(2001) 276: 28226; Biochemistry (2002) 41: 2388]. Their laboratory
has been continuously supported by the NIH since 1971. |