MECHANISMS OF GENETIC HYPERTENSION

Mentor:          Mouhamed Awayda

                        Assistant Professor

                        Physiology Department, SL-35

                        Tulane University Medical School        

                        1430 Tulane Avenue

                        New Orleans, LA 70112

                        (504) 584-2509

                        E-mail:  mawayda@tulane.edu

Description:

This project utilizes molecular biological as well as electrophysiological techniques to study gain of function mutations of the epithelial Na+ channel.  This channel and mutations thereof are implicated in multiple forms of genetic hyper- and hypo-tension.  These mutations lead to changes of channel activity and ultimately salt and water reabsorption.  We have previously identified multiple channel domains that lead to changes of channel activity.  This project deals with a better characterization of the molecular mechanisms of these domains and how they regulate channel function and ultimately blood volume and pressure.
 

This project requires a high degree of dedication and has the potential for paid/volunteer
research during the academic year.  Qualifications include prior laboratory experience, good grasp of Physiology/Cell Biology and most of all dedication to complete this potentially rewarding work.

Home LS-LAMP at Tulane Summer Program Description Application 

LS-LAMP Participants State LS-LAMP Homepage National Science Foundation

Tulane University Page Credits