2.Microscopic image processing and industrial software development

The PI, Dr. Wang, has many years of industrial experiences and made contributions to commercializing cytogenetic imaging analysis products. He has worked in bio-industry on various genomic imaging techniques including chromosome G-banding, FISH/M-FISH and microarray imaging under a number of NIH Small Business Innovation Research (SBIR) awards in collaboration with Texas Medical Center in Houston. He was the key team player in the development of PowerGeneTM chromosome karyotyping system and PowerProbeTM FISH system that are now widely used in the market.

a. Yu-Ping Wang, Q. Wu, Ken Castleman, and Z. Xiong, Chromosome Image Enhancement Using Multiscale Differential Operators, IEEE Trans. Medical Imaging, vol. 22, no.5, May, 2003.

b. Z. Liu, Z. Xiong, Q. Wu, Y. Wang, and K. Castleman, Cascaded differential and wavelet compression of chromosome images, IEEE Trans. on Biomedical Engineering, vol. 49, no. 4, 2002.

c. Yu-Ping Wang and Ken Castleman, Automated Registration of Multi-Color Fluorescence In Situ Hybridization (M-FISH) Images for Improving Color Karyotyping, Cytometry, Part A, 64A(2), April, 2005.

Given our experiences in developing industrial image processing software under SBIR research, we plan to

establish a close collaboration with the industry in the next few years so that some of our research results can be commercialized.